Results 251 to 260 of about 2,252,807 (303)
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Fueling the fire of B cell activation
Science Immunology, 2023Antigen activated naïve B cells undergoing germinal center responses have distinct metabolic requirements.
Patricia M. Sikorski, Linda L. Kusner
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B Cell Activation and Apoptosis
1995The antigen recognition potential of lymphocytes is theoretically so vast that, without appropriate regulation, the immune system should inevitably react to self-antigens. The development of B and T lymphocytes is therefore controlled at multiple levels in order to ensure that individuals will be able to respond to a large array of foreign antigens ...
P, Sarthou, L, Benhamou, P A, Cazenave
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Current Opinion in Immunology, 1992
Extraordinary progress has been made in refining our understanding of the B-cell antigen receptor complex, the role of protein-tyrosine phosphorylation as the key intermediary in immunoglobulin signal transduction, and in identifying candidate effectors of immunoglobulin-mediated signaling.
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Extraordinary progress has been made in refining our understanding of the B-cell antigen receptor complex, the role of protein-tyrosine phosphorylation as the key intermediary in immunoglobulin signal transduction, and in identifying candidate effectors of immunoglobulin-mediated signaling.
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T-cell-mediated activation of B cells
Current Opinion in Immunology, 1991Antibody responses to protein antigens are dependent on helper T lymphocytes, which provide necessary growth and differentiation, inducing stimuli to antigen-specific B cells. Recent investigations have focused on the mechanisms of T-B interactions, and the nature of the T-cell-derived signals that are needed for activation and expansion of B cells.
H J, Burstein, A K, Abbas
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Silencing and activating anergic B cells*
Immunological Reviews, 2021AbstractDespite the existence of central tolerance mechanisms, including clonal deletion and receptor editing to eliminate self‐reactive B cells, moderately self‐reactive cells still survive in the periphery (about 20% of peripheral B cells). These cells normally exist in a functionally silenced state called anergy; thus, anergy has been thought to ...
Shinya Tanaka +3 more
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T Cell‐Dependent B Cell Activation
Immunological Reviews, 1984T cell-dependent induction of small, resting B lymphocytes requires direct recognition of antigen and/or I-A/E molecules on the B cell surface by the inducing helper cell, and it does not require the participation of Ig receptors on the responding B cell.
A, Coutinho +7 more
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T Cell\-Dependent B Cell Activation
Annual Review of Immunology, 1993B cells obtain help from T cells in the antibody response by acting as antigen-specific antigen presenting cells. A direct signal through binding of antigen to membrane Ig can enhance B cell antigen presentation and T-dependent B cell activation, but is not required for a productive interaction between a small resting B cell and a differentiated helper
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Studies on B-cell activation in vitro
Annales de l'Institut Pasteur / Immunologie, 1983When antigen activates B cells with the help of T cells, factors are produced by T cells which induce proliferation and maturation to Ig-secreting cells. T-cell lines and T-cell hybridomas have been obtained which, upon stimulation by antigen or by concanavalin A, produce these B-cell replication and maturation factors.
F, Melchers, C, Corbel
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B cell activation in multiple sclerosis
Acta Neurologica Scandinavica, 1986A microtechnique was established for the study of the limited numbers of cells available in CSF. The method allowed for the determination of the number of immunoglobulin-secreting cells (IgSC) as well as the quantitation of immunoglobulin or specific antibody secreted into the culture medium.
M, Sandberg +3 more
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Early Events in B Cell Activation
Annual Review of Immunology, 2010B cell activation is initiated by the ligation of the B cell receptor (BCR) with antigen and ultimately results in the production of protective antibodies against potentially pathogenic invaders. Here we review recent literature concerned with the spatiotemporal dynamic characterization of the early molecular events of B cell activation, including the ...
Naomi E Harwood, Facundo D Batista
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