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Dasatinib Is Preferentially Active in the Activated B-Cell Subtype of Diffuse Large B-Cell Lymphoma
Journal of Proteome Research, 2018Diffuse large B-cell lymphoma (DLBCL) is a heterogeneous disease, and at least one-third of its patients relapse after treatment with the current chemotherapy regimen, R-CHOP. By gene-expression profiling, patients with DLBCL can be categorized into two clinically relevant subtypes: activated B-cell (ABC) and germinal center B-cell (GCB) DLBCL ...
Marissa L. Cann +7 more
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Lipid rafts and B-cell activation
Nature Reviews Immunology, 2002The B-cell antigen receptor acts during B-cell activation both to initiate signalling cascades and to transport antigen into the cell for subsequent processing and presentation. Recent evidence indicates that membrane microdomains, termed lipid rafts, have a role in B-cell activation as platforms for B-cell receptor (BCR) signalling and might also act ...
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B cells as antigen-presenting cells: the requirement for B cell activation.
The Journal of Immunology, 1983Abstract In this study we have extended our previous work on the capacity of B cells to act as antigen-presenting cells (APC) to investigate the requirements for activation and antigen concentration when antigen uptake is mediated by binding to surface immunoglobulin. We investigated the requirements for B cell activation for stimulation
T, Kakiuchi, R W, Chesnut, H M, Grey
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Transcriptional Control of B Cell Activation
2005The developmental program that commits a hematopoietic stem cell to the B lymphocyte lineage employs transcriptional regulators to enable the assembly of an antigen receptor complex with a useful specificity and with signalling competence. Once a naive IgM+ B cell is generated, it must correctly integrate signals from the antigen receptor with those ...
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Memory B Cells but not Virgin B Cells are Activated in Germinal Centers
1988In chimaeras constructed by transferring K-allotype distinct DNP-haemocyanin-primed thoracic duct lymphocytes (TDL) into irradiated (hind limb bone marrow shielded) recipients the activation of virgin (host allotype) B cells is often transient falling to negligible levels within 14 days (1).
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AP-1 activity induced by co-stimulation is required for chromatin opening during T cell activation
Journal of Experimental Medicine, 2020Masashi Yukawa +2 more
exaly