Regulation of B cell fate by chronic activity of the IgE B cell receptor [PDF]
eLife, 2016 IgE can trigger potent allergic responses, yet the mechanisms regulating IgE production are poorly understood. Here we reveal that IgE+ B cells are constrained by chronic activity of the IgE B cell receptor (BCR).
Zhiyong Yang +6 more
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Is the vaccination-induced B cell receptor repertoire predictable? [PDF]
ImmunoInformaticsVaccines trigger an immune response that results in a population of memory cells that can quickly respond to subsequent antigen re-encounters. Most vaccines are designed to induce memory B cells with vaccine-specific B cell receptors (BCRs).
Eve Richardson +4 more
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Unique chicken B cell development: species-specific mechanisms and contradictory requirements of B cell receptor for post-hatched B cell development [PDF]
Frontiers in ImmunologyChicken B cell development represents a remarkable evolutionary divergence from mammalian paradigms, featuring unique three-stage ontogeny centered on the bursa of Fabricius, an avian-specific primary B cell lymphoid organ.
Seung Je Woo +2 more
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T-cell receptor and B-cell receptor repertoires profiling in pleural tuberculosis [PDF]
Frontiers in ImmunologyBackgroundTuberculosis (TB) is a leading cause of death worldwide from a single infectious agent. In China the most common extra-pulmonary TB (EPTB) is pleural tuberculosis (PLTB).
Fengjiao Du +12 more
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Thrifty wide-context models of B cell receptor somatic hypermutation [PDF]
eLifeSomatic hypermutation (SHM) is the diversity-generating process in antibody affinity maturation. Probabilistic models of SHM are needed for analyzing rare mutations, understanding the selective forces guiding affinity maturation, and understanding the ...
Kevin Sung +6 more
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B cell receptor repertoire abnormalities in autoimmune disease [PDF]
Frontiers in ImmunologyB cells play a crucial role in the immune response and contribute to various autoimmune diseases. Recent studies have revealed abnormalities in the B cell receptor (BCR) repertoire of patients with autoimmune diseases, with distinct features observed ...
Hayato Yuuki +7 more
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Dynamics and activation of membrane-bound B cell receptor assembly [PDF]
Communications BiologyB-cell receptor (BCR) complexes are expressed on the surface of a B-cell and are critical in antigen recognition and modulating the adaptive immune response.
Hung N. Do +3 more
doaj +2 more sources
B cell receptor dependent enhancement of dengue virus infection. [PDF]
PLoS PathogensDengue virus (DENV) is the causative agent of dengue, a mosquito-borne disease that represents a significant and growing public health burden around the world.
Chad Gebo +12 more
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Aberrant B Cell Signaling in Autoimmune Diseases
Cells, 2022 Aberrant B cell signaling plays a critical in role in various systemic and organ-specific autoimmune diseases. This is supported by genetic evidence by many functional studies in B cells from patients or specific animal models and by the observed ...
Odilia B. J. Corneth +2 more
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Immunoglobulin M-degrading enzyme of Streptococcus suis (IdeSsuis) impairs porcine B cell signaling
Frontiers in Immunology, 2023 Streptococcus suis (S. suis) is an important porcine pathogen, causing severe disease like meningitis and septicemia primarily in piglets. Previous work showed that the IgM-degrading enzyme of S.
Annika Katharina Breitfelder +6 more
doaj +1 more source