Results 1 to 10 of about 1,740,499 (263)

Method for B Cell Receptor Enrichment in Malignant B Cells. [PDF]

Cancers (Basel)
B cells are central to the adaptive immune response and provide long-lasting immunity after infection. B cell activation is mediated by the surface membrane-bound B cell receptor (BCR) following recognition of a specific antigen. The BCR has been challenging to analyse using mass spectrometry (MS) due to the difficulty of isolating and enriching this ...
Bhattacharyya P, Christopherson RI, Skarratt KK, Fuller SJ.   +3 more
europepmc   +3 more sources

T-cell receptor and B-cell receptor repertoires profiling in pleural tuberculosis. [PDF]

Front Immunol
BackgroundTuberculosis (TB) is a leading cause of death worldwide from a single infectious agent. In China the most common extra-pulmonary TB (EPTB) is pleural tuberculosis (PLTB). An important clinical feature of PLTB is that the lymphocytes associated with TB will accumulate in the pleural fluid.
Du F, Deng Y, Deng L, Du B, Xing A, Tao H, Li H, Xie L, Zhang X, Sun T, Li H.   +10 more
europepmc   +4 more sources

B cell receptor (BCR) endocytosis. [PDF]

Prog Mol Biol Transl Sci, 2023
The B cell receptor (BCR) interacts with foreign antigens to mediate B cell activation and secretion of antibodies. B cell activation begins with initiation of signaling pathways, such as NFAT, NF-κB, and MAPK, and endocytosis of the BCR-antigen complex. Many studies have investigated the signaling pathways associated with BCR activation, and this work
Roberts AD, Taraska JW.
europepmc   +3 more sources

Mechanisms of B Cell Receptor Activation and Responses to B Cell Receptor Inhibitors in B Cell Malignancies [PDF]

Cancers, 2020
The B cell receptor (BCR) pathway has been identified as a potential therapeutic target in a number of common B cell malignancies, including chronic lymphocytic leukemia, diffuse large B cell lymphoma, Burkitt lymphoma, follicular lymphoma, mantle cell lymphoma, marginal zone B cell lymphoma, and Waldenstrom’s macroglobulinemia.
Dimitar G. Efremov, Sven Turkalj, Luca Laurenti   +2 more
openaire   +4 more sources

The B cell receptor, but not the pre-B cell receptor, mediates arrest of B cell differentiation [PDF]

European Journal of Immunology, 2000
B cell development in organ cultures of fetal liver from mice at day 14 of gestation resembles in kinetics and cell numbers generated the one observed in vivo. This development in vitro can be blocked by an IL-7 receptor-specific monoclonal antibody. Monoclonal antibodies specific for the pre-B cell receptor, i. e. for VpreB, lambda5, or muH chains, do
Antonius Rolink, Jan Andersson, Rhodri Ceredig, Fritz Melchers   +3 more
openaire   +3 more sources

Revising B Cell Receptors [PDF]

The Journal of Experimental Medicine, 2000
B cell development is often portrayed as a series of decision points that expand an antigen-reactive cell to a clone producing a single antibody. This is hardly the case: B cell development is dependent on a series of error-prone, random rearrangement events that through ongoing ...
David Nemazee, Martin Weigert
openaire   +3 more sources

Targeting of B‐cell receptor signalling in B‐cell malignancies [PDF]

Journal of Internal Medicine, 2017
AbstractPharmacological agents that inhibit enzymes of the B‐cell receptor (BCR) pathway are of increasing importance in the treatment of B‐cell malignancies. These include inhibitors of Bruton tyrosine kinase (BTK), phosphatidylinositol 3‐kinase (PI3K), splenic tyrosine kinase and protein kinase Cβ.
M. Jerkeman, M. Hallek, M. Dreyling, C. Thieblemont, E. Kimby, L. Staudt   +5 more
openaire   +4 more sources

Polyspecificity of T cell and B cell receptor recognition [PDF]

Seminars in Immunology, 2007
A recent workshop discussed the recognition of multiple distinct ligands by individual T cell and B cell receptors and the implications of this discovery for lymphocyte biology. The workshop recommends general use of the term polyspecificity because it emphasizes two fundamental aspects, the inherent specificity of receptor recognition and the ability ...
Kai W. Wucherpfennig, Philip D. Hodgkin, Rob J. de Boer, David Nemazee, Roland K. Strong, Clemencia Pinilla, David A. Hafler, Erik S. Huseby, Ralph J. Greenspan, David C. Krakauer, Byron Goldstein, Franco Celada, Alan S. Perelson, Paul M. Allen, K. Christopher Garcia, Eli E. Sercarz, Irun R. Cohen   +16 more
openaire   +3 more sources

Unveiling the B cell receptor structure

Science, 2022
Molecular structures provide a road map for understanding and controlling B cell receptor ...
Tolar, P, Pierce, SK
openaire   +3 more sources

B Cell Receptor and BAFF Receptor Signaling Regulation of B Cell Homeostasis [PDF]

The Journal of Immunology, 2009
Abstract B lymphocyte homeostasis depends on tonic and induced BCR signaling and receptors sensitive to trophic factors, such as B cell-activating factor receptor (BAFF-R or BR3) during development and maintenance. This review will discuss growing evidence suggesting that the signaling mechanisms that maintain B cell survival and ...
openaire   +3 more sources