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Is the vaccination-induced B cell receptor repertoire predictable? [PDF]
ImmunoInformaticsVaccines trigger an immune response that results in a population of memory cells that can quickly respond to subsequent antigen re-encounters. Most vaccines are designed to induce memory B cells with vaccine-specific B cell receptors (BCRs).
Eve Richardson +4 more
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B cell receptor (BCR) endocytosis. [PDF]
Prog Mol Biol Transl Sci, 2023 The B cell receptor (BCR) interacts with foreign antigens to mediate B cell activation and secretion of antibodies. B cell activation begins with initiation of signaling pathways, such as NFAT, NF-κB, and MAPK, and endocytosis of the BCR-antigen complex. Many studies have investigated the signaling pathways associated with BCR activation, and this work
Roberts AD, Taraska JW.
europepmc +3 more sources
T-cell receptor and B-cell receptor repertoires profiling in pleural tuberculosis [PDF]
Frontiers in ImmunologyBackgroundTuberculosis (TB) is a leading cause of death worldwide from a single infectious agent. In China the most common extra-pulmonary TB (EPTB) is pleural tuberculosis (PLTB).
Fengjiao Du +12 more
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B cell receptor repertoire abnormalities in autoimmune disease [PDF]
Frontiers in ImmunologyB cells play a crucial role in the immune response and contribute to various autoimmune diseases. Recent studies have revealed abnormalities in the B cell receptor (BCR) repertoire of patients with autoimmune diseases, with distinct features observed ...
Hayato Yuuki +7 more
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B cell receptor dependent enhancement of dengue virus infection. [PDF]
PLoS PathogensDengue virus (DENV) is the causative agent of dengue, a mosquito-borne disease that represents a significant and growing public health burden around the world.
Chad Gebo +12 more
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Aberrant B Cell Signaling in Autoimmune Diseases
Cells, 2022 Aberrant B cell signaling plays a critical in role in various systemic and organ-specific autoimmune diseases. This is supported by genetic evidence by many functional studies in B cells from patients or specific animal models and by the observed ...
Odilia B. J. Corneth +2 more
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Exploration of Immunology, 2021 Coronavirus disease-2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus (SARS-CoV)-2 spread globally and creates an alarming situation.
Kabeer Haneef +7 more
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Revising B Cell Receptors [PDF]
The Journal of Experimental Medicine, 2000 B cell development is often portrayed as a series of decision points that expand an antigen-reactive cell to a clone producing a single antibody. This is hardly the case: B cell development is dependent on a series of error-prone, random rearrangement events that through ongoing ...
D, Nemazee, M, Weigert
openaire +2 more sources
Human Vaccines & Immunotherapeutics, 2021 The Hepatitis B (HB) vaccine is efficacious in preventing hepatitis B virus infection. However, the association between antibody response to the HB vaccine and dynamic immune repertoire changes in different cell subsets remains unclear.
Miaoxian Zhao +8 more
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