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Current Opinion in Immunology, 1994
Antigen receptors have a dual role on the surface of B lymphocytes, namely the binding and internalization of antigens and the activation of the antigen-recognizing B cell. The structural requirements for internalization are still a matter of controversy; but as far as signalling is concerned it is becoming increasingly apparent that the antigen ...
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Antigen receptors have a dual role on the surface of B lymphocytes, namely the binding and internalization of antigens and the activation of the antigen-recognizing B cell. The structural requirements for internalization are still a matter of controversy; but as far as signalling is concerned it is becoming increasingly apparent that the antigen ...
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B-cell receptor regulation of peripheral B cells
Current Opinion in Immunology, 1998Recent studies indicate that immature B cells compete with recirculating B cells for survival signals. The signals, delivered through the B-cell receptor for antigen, induce immature cells to differentiate into recirculating cells and maintain the survival of recirculating cells. They do not induce proliferation or differentiation to antibody-producing
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B cell receptor signal strength determines B cell fate
Nature Immunology, 2004B cell receptor (BCR)-mediated antigen recognition is thought to regulate B cell differentiation. BCR signal strength may also influence B cell fate decisions. Here, we used the Epstein-Barr virus protein LMP2A as a constitutively active BCR surrogate to study the contribution of BCR signal strength in B cell differentiation.
Casola S. +7 more
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Distinct processing of the pre-B cell receptor and the B cell receptor
Molecular Immunology, 2013It has been recently demonstrated that while oligosaccharide moieties of μ heavy chains in the B-cell receptor (BCR) are of the complex type as expected, those of the pre-BCR on the surface of pre-B cells contain oligosaccharide moieties of the high-mannose type only.
Sharon, Cohen +2 more
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Stereotyped B Cell Receptor Immunoglobulins in B Cell Lymphomas
2019Comprehensive analysis of the clonotypic B cell receptor immunoglobulin (BcR IG) gene rearrangement sequences in patients with mature B cell neoplasms has led to the identification of significant repertoire restrictions, culminating in the discovery of subsets of patients expressing highly similar, stereotyped BcR IG.
Andreas, Agathangelidis +2 more
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Chimeric autoantibody receptor T cells deplete NMDA receptor-specific B cells
Cell, 2023Anti-NMDA receptor (NMDAR) autoantibodies cause NMDAR encephalitis, the most common autoimmune encephalitis, leading to psychosis, seizures, and autonomic dysfunction. Current treatments comprise broad immunosuppression or non-selective antibody removal.
Reincke, S Momsen +15 more
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Receptor cooperation in B cells
Science Signaling, 2017TLR4-stimulated B cell activation is mediated by the tyrosine kinase Syk and depends on the B cell receptor.
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2018
What does the BCR do and why is it critical in normal B-cell development? What is its role in B-cell maturation and the biological responses including activation, tolerance, and/or differentiation? What is its role in CLL? Here, the focus is on the current understanding of the BCR signal cascade in normal B cells and its altered path in CLL that ...
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What does the BCR do and why is it critical in normal B-cell development? What is its role in B-cell maturation and the biological responses including activation, tolerance, and/or differentiation? What is its role in CLL? Here, the focus is on the current understanding of the BCR signal cascade in normal B cells and its altered path in CLL that ...
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1999
Publisher Summary This chapter reviews the essential facts related to the organization of immunoglobulin genes, V(D)J recombination, and B-cell development. The chapter also presents how signals from the antigen receptor influence gene rearrangements during development, tolerance-induction, and immunity.
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Publisher Summary This chapter reviews the essential facts related to the organization of immunoglobulin genes, V(D)J recombination, and B-cell development. The chapter also presents how signals from the antigen receptor influence gene rearrangements during development, tolerance-induction, and immunity.
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Stereotyped B-Cell Receptor Immunoglobulins in B-Cell Lymphomas
Thorough examination of clonotypic B-cell receptor immunoglobulin (BcR IG) gene rearrangement sequences in patients with mature B-cell malignancies has revealed significant repertoire restrictions, leading to the identification of subsets of patients expressing highly similar, stereotyped BcR IG.Andreas, Agathangelidis +4 more
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