Results 251 to 260 of about 2,912,674 (304)
Some of the next articles are maybe not open access.
B cell receptor (BCR) endocytosis
2023The B cell receptor (BCR) interacts with foreign antigens to mediate B cell activation and secretion of antibodies. B cell activation begins with initiation of signaling pathways, such as NFAT, NF-κB, and MAPK, and endocytosis of the BCR-antigen complex. Many studies have investigated the signaling pathways associated with BCR activation, and this work
Aleah D, Roberts, Justin W, Taraska
openaire +2 more sources
2008
The subunit structure of the B-cell antigen receptor (BCR) and its associated compartmentalization of function confer enormous flexibility for generating signals and directing these toward specific and divergent cell fate decisions. Like all the multichain immune recognition receptors discussed in this volume, assembly of these multi-unit complexes ...
Randall J, Brezski, John G, Monroe
openaire +2 more sources
The subunit structure of the B-cell antigen receptor (BCR) and its associated compartmentalization of function confer enormous flexibility for generating signals and directing these toward specific and divergent cell fate decisions. Like all the multichain immune recognition receptors discussed in this volume, assembly of these multi-unit complexes ...
Randall J, Brezski, John G, Monroe
openaire +2 more sources
Current Opinion in Immunology, 2007
The pre-B-cell receptor (pre-BCR) is composed of two immunoglobulin mu heavy chains and two surrogate light chains, which associate with the signaling molecules Igalpha and Igbeta (Igalpha/beta). The production of a functional pre-BCR is the first checkpoint in the current model of B-cell development.
Inga-Lill, Mårtensson +2 more
openaire +2 more sources
The pre-B-cell receptor (pre-BCR) is composed of two immunoglobulin mu heavy chains and two surrogate light chains, which associate with the signaling molecules Igalpha and Igbeta (Igalpha/beta). The production of a functional pre-BCR is the first checkpoint in the current model of B-cell development.
Inga-Lill, Mårtensson +2 more
openaire +2 more sources
Current Opinion in Immunology, 1994
Antigen receptors have a dual role on the surface of B lymphocytes, namely the binding and internalization of antigens and the activation of the antigen-recognizing B cell. The structural requirements for internalization are still a matter of controversy; but as far as signalling is concerned it is becoming increasingly apparent that the antigen ...
openaire +2 more sources
Antigen receptors have a dual role on the surface of B lymphocytes, namely the binding and internalization of antigens and the activation of the antigen-recognizing B cell. The structural requirements for internalization are still a matter of controversy; but as far as signalling is concerned it is becoming increasingly apparent that the antigen ...
openaire +2 more sources
B-cell receptor regulation of peripheral B cells
Current Opinion in Immunology, 1998Recent studies indicate that immature B cells compete with recirculating B cells for survival signals. The signals, delivered through the B-cell receptor for antigen, induce immature cells to differentiate into recirculating cells and maintain the survival of recirculating cells. They do not induce proliferation or differentiation to antibody-producing
openaire +2 more sources
B cell receptor signal strength determines B cell fate
Nature Immunology, 2004B cell receptor (BCR)-mediated antigen recognition is thought to regulate B cell differentiation. BCR signal strength may also influence B cell fate decisions. Here, we used the Epstein-Barr virus protein LMP2A as a constitutively active BCR surrogate to study the contribution of BCR signal strength in B cell differentiation.
Casola S. +7 more
openaire +2 more sources
Distinct processing of the pre-B cell receptor and the B cell receptor
Molecular Immunology, 2013It has been recently demonstrated that while oligosaccharide moieties of μ heavy chains in the B-cell receptor (BCR) are of the complex type as expected, those of the pre-BCR on the surface of pre-B cells contain oligosaccharide moieties of the high-mannose type only.
Sharon, Cohen +2 more
openaire +2 more sources
Stereotyped B Cell Receptor Immunoglobulins in B Cell Lymphomas
2019Comprehensive analysis of the clonotypic B cell receptor immunoglobulin (BcR IG) gene rearrangement sequences in patients with mature B cell neoplasms has led to the identification of significant repertoire restrictions, culminating in the discovery of subsets of patients expressing highly similar, stereotyped BcR IG.
Andreas, Agathangelidis +2 more
openaire +2 more sources
Chimeric autoantibody receptor T cells deplete NMDA receptor-specific B cells
Cell, 2023Anti-NMDA receptor (NMDAR) autoantibodies cause NMDAR encephalitis, the most common autoimmune encephalitis, leading to psychosis, seizures, and autonomic dysfunction. Current treatments comprise broad immunosuppression or non-selective antibody removal.
Reincke, S Momsen +15 more
openaire +4 more sources
Receptor cooperation in B cells
Science Signaling, 2017TLR4-stimulated B cell activation is mediated by the tyrosine kinase Syk and depends on the B cell receptor.
openaire +2 more sources