Results 261 to 270 of about 2,912,674 (304)

B-Cell Receptors

2018
What does the BCR do and why is it critical in normal B-cell development? What is its role in B-cell maturation and the biological responses including activation, tolerance, and/or differentiation? What is its role in CLL? Here, the focus is on the current understanding of the BCR signal cascade in normal B cells and its altered path in CLL that ...
openaire   +1 more source

Receptor Editing in B Cells

1999
Publisher Summary This chapter reviews the essential facts related to the organization of immunoglobulin genes, V(D)J recombination, and B-cell development. The chapter also presents how signals from the antigen receptor influence gene rearrangements during development, tolerance-induction, and immunity.
openaire   +2 more sources

Stereotyped B-Cell Receptor Immunoglobulins in B-Cell Lymphomas

Thorough examination of clonotypic B-cell receptor immunoglobulin (BcR IG) gene rearrangement sequences in patients with mature B-cell malignancies has revealed significant repertoire restrictions, leading to the identification of subsets of patients expressing highly similar, stereotyped BcR IG.
Andreas, Agathangelidis, Athanasios, Roussos, Konstantinos, Kardamiliotis, Fotis, Psomopoulos, Kostas, Stamatopoulos   +4 more
openaire   +2 more sources

B Cell Receptor Togetherness

Science Signaling, 2010
Activation of the B cell receptor appears to require release of the receptors from an autoinhibited, oligomeric state.
openaire   +1 more source

Critical care management of chimeric antigen receptor T‐cell therapy recipients

Ca-A Cancer Journal for Clinicians, 2022
Alexander Shimabukuro-Vornhagen, Boris Böll, Peter Schellongowski   +2 more
exaly  

Chimeric antigen receptor T‐cell therapy in multiple myeloma: A comprehensive review of current data and implications for clinical practice

Ca-A Cancer Journal for Clinicians, 2023
Rujul Parikh, Sagar Lonial
exaly  

Systemic therapy for hormone receptor‐positive/human epidermal growth factor receptor 2‐negative early stage and metastatic breast cancer

Ca-A Cancer Journal for Clinicians, 2023
Laura A Huppert, Hope S Rugo
exaly  

Clinical insights into small cell lung cancer: Tumor heterogeneity, diagnosis, therapy, and future directions

Ca-A Cancer Journal for Clinicians, 2023
Carl M Gay, Helmut H Popper, Robert Pirker   +2 more
exaly  

A review of cancer immunotherapy toxicity

Ca-A Cancer Journal for Clinicians, 2020
Lucy Boyce Kennedy
exaly  

An interdisciplinary consensus on the management of brain metastases in patients with renal cell carcinoma

Ca-A Cancer Journal for Clinicians, 2022
Elshad Hasanov, Marion Smits, Shaan Dudani   +2 more
exaly