Results 21 to 30 of about 1,897,024 (307)
Autoimmunity, 2019 Silicosis is an occupational fibrotic lung disease, which is associated with an increased incidence of autoimmune diseases. The effect of crystalline silica on the immune system is thought to be mediated by the antigen presenting cells.
Theodoros Eleftheriadis +4 more
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Targeting of B‐cell receptor signalling in B‐cell malignancies [PDF]
Journal of Internal Medicine, 2017 AbstractPharmacological agents that inhibit enzymes of the B‐cell receptor (BCR) pathway are of increasing importance in the treatment of B‐cell malignancies. These include inhibitors of Bruton tyrosine kinase (BTK), phosphatidylinositol 3‐kinase (PI3K), splenic tyrosine kinase and protein kinase Cβ.
M. Jerkeman +5 more
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Drugs in Context, 2019 B-cell non-Hodgkin lymphoma (NHL) is the most frequent hematologic malignancy. Despite the refinement of chemoimmunotherapy, a substantial number of patients experience chemorefractory disease.
Shinichi Makita +3 more
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B Cell Receptor Crosslinking Augments Germinal Center B Cell Selection when T Cell Help Is Limiting
Cell Reports, 2018 Summary: Antigen-dependent engagement of germinal center (GC) B cell receptors (BCRs) promotes antigen internalization and presentation for follicular helper T cells.
Jackson Steed Turner +2 more
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Frontiers in Immunology, 2022 B cells can act as potent suppressors of anti-tumor T cell immunity, presenting a mechanism of resistance to immunotherapy. In pancreatic ductal adenocarcinoma, B cells can display a T cell-suppressive or regulatory phenotype centered on the expression ...
Daniel Michaud +6 more
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B Cell Receptor and BAFF Receptor Signaling Regulation of B Cell Homeostasis [PDF]
The Journal of Immunology, 2009 Abstract B lymphocyte homeostasis depends on tonic and induced BCR signaling and receptors sensitive to trophic factors, such as B cell-activating factor receptor (BAFF-R or BR3) during development and maintenance. This review will discuss growing evidence suggesting that the signaling mechanisms that maintain B cell survival and ...
openaire +2 more sources
Current Directions in Biomedical Engineering, 2015 Automated image processing methods enable objective, reproducible and high quality analysis of fluorescent cell images in a reasonable amount of time. Therefore, we propose the application of image processing pipelines based on established segmentation ...
Wiesmann Veit +5 more
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Regulation of B cell fate by chronic activity of the IgE B cell receptor
eLife, 2016 IgE can trigger potent allergic responses, yet the mechanisms regulating IgE production are poorly understood. Here we reveal that IgE+ B cells are constrained by chronic activity of the IgE B cell receptor (BCR).
Zhiyong Yang +6 more
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Multi-faceted regulation of IgE production and humoral memory formation
Allergology International, 2021 IgE antibodies play a protective role against parasites and environmental toxins by its strong effector functions. However, aberrant IgE production can contribute to the development of allergic disorders, and thus is tightly regulated.
Kei Haniuda, Daisuke Kitamura
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B cell receptor signaling strength modulates cancer immunity
The Journal of Clinical Investigation, 2022 Tumor-infiltrating B cells exert antitumor effects by producing antibodies against tumor-associated antigens. Conversely, B cells may promote tumors through the production of factors that dampen antitumor immunity.
Jian Ye, Peter P. Lee
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