Results 91 to 100 of about 4,351,772 (298)

Goodbye flat lymphoma biology

FEBS Letters, EarlyView.
Three‐dimensional (3D) biological systems have become key tools in lymphoma research, offering reliable in vitro and ex vivo platforms to explore pathogenesis and support precision medicine. This review highlights current 3D non‐Hodgkin lymphoma models, detailing their features, advantages, and limitations, and provides a broad perspective on future ...
Carla Faria, Cèlia Dobaño‐López, Patricia Pérez‐Galán, Christine Bezombes   +3 more
wiley   +1 more source

Features of B cell subsets in primary Sjogren’s syndrome and systemic lupus erythematosus

Научно-практическая ревматология
Background. Lymphocyte subsets in autoimmune diseases, such as systemic lupus erythematosus (SLE) and primary Sjogren’s syndrome (pSS), have been intensively studied in recent years.
S. S. Benevolenskaya, I. V. Kudriavtsev, M. K. Serebriakova, I. N. Grigor’yeva, E. S. Kuvardin, A. I. Budkova, S. V. Koniakhin, D. B. Zammoeva, D. B. Motorin, A. Yu. Zaritskey, I. Z. Gaydukova, E. K. Gaydukova, S. V. Lapin, A. L. Maslyanskiy   +13 more
doaj   +1 more source

Alterations in Peripheral B Cell Subsets Correlate with the Disease Severity of Human Glaucoma

Journal of Inflammation Research, 2021
Ling Yu,1,* Yang Chen,2,* Xiang Xu,2 Qiwei Dong,2,3 Wenbo Xiu,2 Qinyuan Chen,2 Jinxia Wang,2 Chong He,2,3 Jian Ye,1 Fang Lu2,3 1Department of Ophthalmology, Daping Hospital, Army Medical Center, Army Medical University, Chongqing, People’s ...
Yu L, Chen Y, Xu X, Dong Q, Xiu W, Chen Q, Wang J, He C, Ye J, Lu F   +9 more
doaj  

From omics to AI—mapping the pathogenic pathways in type 2 diabetes

FEBS Letters, EarlyView.
Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan, Lu Qi, Pierre Zalloua   +2 more
wiley   +1 more source

Transport of B-Vitamins in Microorganisms. V. Comparative Studies on the ATP-hydrolyzing Activities of Cell Fractions Obtained from Thiamine Sufficient and Thiamine Deficient Cells of L. fermenti. [PDF]

, 1966
Halina Y. Neujahr, Zoltán Varga, Jorunn Sletten, Marc Wagnières, Dudley H. Williams, E. Bunnenberg, Carl Djerassi, Ruth Records   +7 more
openalex   +1 more source

The anabolic steroid stanozolol is a potent inhibitor of human MutT homolog 1

FEBS Letters, EarlyView.
MutT homolog 1 (MTH1) is a member of the NUDIX superfamily of enzymes and is an anticancer drug target. We show that stanozolol (Stz), an anabolic steroid, is an unexpected nanomolar inhibitor of MTH1. The X‐ray crystal structure of the human MTH1–Stz complex reveals a unique binding scaffold that could be utilized for future inhibitor development ...
Emma Scaletti Hutchinson, Robert Gustafsson Westergren, Ingrid Almlöf, Ann‐Sofie Jemth, Martin Scobie, Ulrika Warpman Berglund, Thomas Helleday, Pål Stenmark   +7 more
wiley   +1 more source

Transport of B-Vitamins in Microorganisms. IV. The Specificity of the High Accumulation of Labelled Thiamine in Non-proliferating Thiamine Deficient Cells of L. fermenti. [PDF]

, 1966
Halina Y. Neujahr, Gunnar Lundblad, Laura Louise Lindqvist, Bengt von Hofsten, Dudley H. Williams, E. Bunnenberg, Carl Djerassi, Ruth Records   +7 more
openalex   +1 more source

Mycobacterium tuberculosis sulfurtransferase SseA is activated by its neighboring gene product Rv3284

FEBS Letters, EarlyView.
Tuberculosis remains a global health challenge and new therapeutic targets are required. Here, we characterized SseA, a sulfurtransferase from Mycobacterium tuberculosis involved in macrophage infection, and its interaction with the newly identified protein SufEMtb that activates SseA enzymatic activity.
Giulia Di Napoli, Alex Fissore, Edoardo Salladini, Eleonora Raccuia, Simonetta Oliaro‐Bosso, Alessia Ruggiero, Rita Berisio, Milagros Medina, Adrian Velazquez‐Campoy, Salvatore Adinolfi, Mauro Marengo   +10 more
wiley   +1 more source

Functional characteristics of the gene promoters of anti-inflammatory cytokines TGF-b and IL-10 in B lymphocyte cell models

Медицинская иммунология
B cells play a crucial role in the pathogenesis of various diseases, such as autoimmune disorders, cancers, and infections. Unlike regulatory T cells, the anti-inflammatory capabilities of B cells have only recently garnered attention.
A. N. Uvarova, A. S. Ustiugova, E. A. Zheremyan, E. M. Stasevich, K. V. Korneev, D. V. Kuprash   +5 more
doaj   +1 more source

The regulatory capacity of B cells directs the aggressiveness of CLL

OncoImmunology, 2019
Chronic lymphocytic leukemia (CLL) is associated with abnormal T-cell responses responsible for defective anti-tumor activities. Intriguingly, CLL B cells share phenotypical characteristics with regulatory B (Breg) cells suggesting that they might ...
Audrey Mohr, Marie Cumin, Cristina Bagacean, Pierre Pochard, Christelle Le Dantec, Sophie Hillion, Yves Renaudineau, Christian Berthou, Adrian Tempescul, Hussam Saad, Jacques-Olivier Pers, Anne Bordron, Christophe Jamin   +12 more
doaj   +1 more source