Results 111 to 120 of about 21,803,006 (294)

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Rituximab Prevents the Development of Experimental Autoimmune Encephalomyelitis (EAE): Comparison with Prophylactic, Therapeutic or Combinational Regimens

Journal of Inflammation Research, 2020
Mena R Al-ani,1 Tom K Raju,2 Mahmood Y Hachim,1,2 Ibrahim Y Hachim,1 Noha M Elemam,1,2 Maha Guimei,1,3 Riyad Bendardaf,4 Azzam A Maghazachi1,2 1Department of Clinical Sciences, College of Medicine, University of Sharjah, Sharjah, 27272, United Arabs ...
Al-ani MR, Raju TK, Hachim MY, Hachim IY, Elemam NM, Guimei M, Bendardaf R, Maghazachi AA   +7 more
doaj  

Autoantigen-specific B cells and plasma cells are prominent in areas of fatty infiltration in salivary glands of patients with primary Sjögren’s syndrome

Autoimmunity, 2019
Salivary and lacrimal gland involvement is a characteristic feature of primary Sjögren’s syndrome (pSS), where tissue destruction is mediated by mononuclear cell infiltration, resulting in lacrimal and salivary gland impairment.
Kathrine Skarstein, Janicke Liaaen Jensen, Hilde Galtung, Roland Jonsson, Karl Brokstad, Lara A. Aqrawi   +5 more
doaj   +1 more source

Salmonella lipopolysaccharide‐containing supported lipid bilayers as platforms to study bacteriophage interactions

FEBS Letters, EarlyView.
We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace, Alyssa Borges, Charles Arnaud, Tove Karlsson, Nina K. Bröker, Stefanie Barbirz, Marta Bally   +6 more
wiley   +1 more source

Possible Role of CD11a in Primary Immune Thrombocytopenia Patients on Immunosuppressive Therapy

Journal of Blood Medicine, 2021
Muhamad R Abdel Hameed,1,2 Howiada A Nafady,1,2 Mona Ibrahim Mostafa,3 Douaa Sayed,4 Ahmad A Obiedallah5 1Hematology Unit, Department of Internal Medicine, Assiut University Hospitals, Assiut University, Assiut, Egypt; 2Bone Marrow Transplantation Unit ...
Abdel Hameed MR, Nafady HA, Mostafa MI, Sayed D, Obiedallah AA   +4 more
doaj  

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Plasmablasts and neuroimmunological disorders

Immunological Medicine, 2019
Neuroimmunological disorders are diseases of the nervous system, wherein the immune system contributes to tissue injury and repair. Autoantibodies are useful biomarkers for the diagnosis of neuroimmunological disorders and evaluating disease activity ...
Norio Chihara, Riki Matsumoto, Takashi Yamamura   +2 more
doaj   +1 more source

Molecular biology of B cells /

Molecular Biology of B Cells, Second Edition is a comprehensive reference to how B cells are generated, selected, activated and engaged in antibody production. All of these developmental and stimulatory processes are described in molecular, immunological,
Honjō, Tasuku,editor., Radbruch, A.(Andreas),editor., Alt, Frederick W.,editor., Reth, Michael,editor.   +3 more
core  

CD180 functions in activation, survival and cycling of B chronic lymphocytic leukaemia cells

, 2011
We previously showed that approximately 60% of B chronic lymphocytic leukaemia (B-CLL) cells express surface CD180, an orphan receptor of the Toll-like receptor family.
Kanti R. Rai, Clark, E.A., Nino Porakishvili, Azka Memon, Chiorazzi, N., Memon, A., Rai, K.R., Lydyard, P.M., Nina Kulikova, Vispute, K., Rajendra N. Damle, Damle, R.N., Amit Nathwani, Nicholas Chiorazzi, Peter M. Lydyard, Nathwani, A., Kulikova, N., Porakishvili, N., Ketki Vispute, Edward A. Clark   +19 more
core   +1 more source