Results 241 to 250 of about 21,803,006 (294)

Hypoxia Independently Induces AID Expression in CH12 B Cells. [PDF]

Eur J Immunol
Heyer V, Haidar Ahmad S, Haddad M, Argentieri I, Gessier C, Reina-San-Martin B.   +5 more
europepmc   +1 more source

Age-associated B cells, key players in autoimmune pathogenesis. [PDF]

Immun Ageing
Hassani SS, Ekrani ST, Rajabinejad M, Faraj TA, Rezaiemanesh A, Esmaeili SA.   +5 more
europepmc   +1 more source

Age-associated B cells and double-negative B cells: two sides of the same coin? The answer depends on the context. [PDF]

Front Aging
Lamprinou M, Sachinidis A, Dimitroulas T.   +2 more
europepmc   +1 more source

Tumor-infiltrating B cells evolve towards interferon-rich trajectories aligned with immunotherapy in melanoma. [PDF]

J Exp Clin Cancer Res
Stoker K, Laddach R, Booth L, Crescioli S, Maiques O, Adams R, Chauhan J, Stewart A, Patel D, Fitzpatrick A, Wu Y, Geh JLC, Salem O, MacKenzie Ross AD, Lloyd-Hughes H, Whittaker S, Ng J, Fraternali F, Kipling D, Dunn-Walters DK, Lacy KE, Tull TJ, Tsoka S, Karagiannis SN.   +23 more
europepmc   +1 more source

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B cells

Critical Care Medicine, 2005
B cells are an important component of adaptive immunity. They produce and secrete millions of different antibody molecules, each of which recognizes a different (foreign) antigen. The fact that humans express a very large repertoire of antibodies is due to the complex mechanism of V(D)J recombination of immunoglobulin (Ig) genes as well as other ...
Malcolm, MacConmara, James A, Lederer
openaire   +4 more sources

To B Cell, or Not to B Cell

Science Signaling, 2000
The transcription factor PU.1 is essential in B cell and macrophage development and proliferation. DeKoter and Singh show that the level of expression of PU.1 can control which cell fate will result. At low levels, PU.1 protein caused precursor cells to differentiate into B lymphocytes; whereas at high levels of PU.1, the same cells differentiated into
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CD5 B cells and B-cell malignancies

Current Opinion in Hematology, 1999
Over the past year, progress has been made in understanding of the physiology and disease associations of CD5+ (B1) B cells, although their exact role in pathogenesis remains unclear. Earlier studies on the negative function of CD5 within the B-cell receptor complex have been substantiated, and it seems likely that soon the signaling pathways used by ...
P M, Lydyard, A P, Jewell, C, Jamin, P Y, Youinou   +3 more
openaire   +2 more sources

Noncanonical B Cells: Characteristics of Uncharacteristic B Cells

The Journal of Immunology, 2023
Abstract B lymphocytes were originally described as a cell type uniquely capable of secreting Abs. The importance of T cell help in Ab production was revealed soon afterward. Following these seminal findings, investigators made great strides in delineating steps in the conventional pathway that B cells follow to produce high-affinity Abs.
openaire   +2 more sources

FOXO in B-cell lymphopoiesis and B cell neoplasia

Seminars in Cancer Biology, 2018
FOX O family transcription factors are important for differentiation and function of multiple cell types. In B lymphocytes they play a critical role. The activity of FOXOs is directly regulated both by signaling from B cell receptor (BCR) and cytokine receptors.
Alexey, Ushmorov, Thomas, Wirth
openaire   +2 more sources