Results 41 to 50 of about 4,351,772 (298)
Targeting mutagenesis in B cells: Phosphorylation goes beyond AID association
Molecular & Cellular Oncology, 2018 The mutations induced by activation-induced cytidine deaminase (AID) trigger antibody diversification but can cause genome instability. We find that AID phosphorylation is an important determinant of “off-target” mutagenesis and identify a drug that ...
Yunxiang Mu, Kevin M. McBride
doaj +1 more source
Germinal center dynamics during acute and chronic infection
Mathematical Biosciences and Engineering, 2017 The ability of the immune system to clear pathogens is limited during chronic virus infections where potent long-lived plasma and memory B-cells are produced only after germinal center B-cells undergo many rounds of somatic hypermutations. In this paper,
Samantha Erwin, Stanca M. Ciupe
doaj +1 more source
Immunological Reviews, 1975 SUMMARYWe consider that 2 'signals’are essential for B cell activation. 'Signal 1’is a consequence of appropriate latticing of surface immunoglobulin receptors. 'Signal 2’can be mediated by a variety of agents. Signal 1 alone (i.e. surface Ig aggregation) leads to a state of B cell tolerance.
Waldmann, H, Munro, A
openaire +4 more sources
Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia
FEBS Letters, EarlyView.This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley +1 more source
CD20 expression in the transplanted kidney of patients with graft loss and transient allograft dysfunction [PDF]
Journal of Medical Biochemistry, 2012 This study aimed to explore the relationship between the infiltration of CD20+ B cells and the survival time of a renal allograft and to investigate the role of infiltrated B cells in the rejection of the renal allograft.
Han Yong +7 more
doaj
Making tau amyloid models in vitro: a crucial and underestimated challenge
FEBS Letters, EarlyView.This review highlights the challenges of producing in vitro amyloid assemblies of the tau protein. We review how accurately the existing protocols mimic tau deposits found in the brain of patients affected with tauopathies. We discuss the important properties that should be considered when forming amyloids and the benchmarks that should be used to ...
Julien Broc, Clara Piersson, Yann Fichou
wiley +1 more source
FEBS Letters, EarlyView.In lymphoid organs, antigen recognition and B cell receptor signaling rely on integrins and the cytoskeleton. Integrins act as mechanoreceptors, couple B cell receptor activation to cytoskeletal remodeling, and support immune synapse formation as well as antigen extraction.
Abhishek Pethe, Tanja Nicole Hartmann
wiley +1 more source
Autoimmunity, 2017 Background: T follicular helper (TFH) cells and B cells are known to regulate humoral immune responses. This study is aimed at examining the putative contribution of different subsets of circulating of TFH cells and B cells to membranous nephropathy (MN).
Zhihui Zhang +5 more
doaj +1 more source
B cells and atherosclerosis [PDF]
American Journal of Physiology-Heart and Circulatory Physiology, 2017 B cells have emerged as important immune cells in cardiovascular disease. Initial studies have suggested that B cells protect against atherosclerosis development. However, subsequent studies demonstrating aggravation of atherosclerosis by B-2 cells have shed light on the subset-dependent effects of B cells.
Coleen A. McNamara, Prasad Srikakulapu
openaire +3 more sources
Cancer Cell, 2021 Tumor-infiltrating B cells complement T cell-mediated antitumor immunity. A panel of experts share their views on the complexity of B cells within the tumor microenvironment, the variety of mechanisms by which these cells control tumor growth, their organization in tertiary lymphoid structures, and their association with immunotherapy response.
Engelhard, Victor +6 more
openaire +3 more sources