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Peptide backbone modifications on the C-terminal hexapeptide of neurotensin
Bioorganic & Medicinal Chemistry Letters, 2008To compare backbone-induced susceptibilities with affinity changes that are caused by side-chain modifications in the respective positions, structure activity relationship studies on a series of NT(8-13) analogues were performed providing valuable insights into the major requirement for neurotensin receptor recognition and activation.
Jürgen, Einsiedel +5 more
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Macrocyclization and Backbone Modification in RiPP Biosynthesis
Annual Review of Biochemistry, 2022The past decade has seen impressive advances in understanding the biosynthesis of ribosomally synthesized and posttranslationally modified peptides (RiPPs). One of the most common modifications found in these natural products is macrocyclization, a strategy also used by medicinal chemists to improve metabolic stability and target affinity and ...
Hyunji, Lee, Wilfred A, van der Donk
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Peptide backbone modifications in lanthipeptides
2021Lanthipeptides are a class of ribosomally synthesized and posttranslationally modified peptide (RiPP) natural products characterized by the presence of lanthionine and methyllanthionine. During the maturation of select lanthipeptides, five different alterations have been observed to the chemical structure of the peptide backbone.
Richard S, Ayikpoe +1 more
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Peptidomimetics and Peptide Backbone Modifications
ChemInform, 2002AbstractFor Abstract see ChemInform Abstract in Full Text.
Jung-Mo, Ahn +3 more
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Incorporation of backbone modifications in mRNA-displayable peptides
2021Here we comprehensively summarize the most recent efforts in our research team, aiming at installing N-methyl and azole backbones into peptides expressed in translation. The genetic code reprogramming using the Flexible In-vitro Translation system (FIT system) has proven to be the most reliable and versatile approach for ribosomally installing various ...
Hiroyuki, Kimura, Hiroaki, Suga
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Backbone modifications for antisense oligonucleotides
Pure and Applied Chemistry, 1997Abstract
Alain De Mesmaeker +3 more
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ChemInform Abstract: Peptide Backbone Modifications
ChemInform, 2008AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Jan Deska, Uli Kazmaier
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