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Protein-backbone-modifications: Formation of imidazolines
European Food Research and Technology, 2005The formation of imidazolines within the backbone during heating of peptides and proteins was studied. In model experiments, the generation of 2-methyl-4-carboxy-imidazoline after incubation of N α -acetyl-β-aminoalanine was demonstrated by cation-exchange chromatography and NMR-studies.
Thomas Paulus +4 more
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Effects of backbone modification on helical peptides: The reduced carbonyl modification
Biopolymers, 1998Reducing a CO to a CH2 moiety in a peptide bond destroys the ability of the peptide link to act as a proton acceptor in a hydrogen-bonded structure. Here, this modification is introduced into different positions of the helical peptide, acetyl-WGG(RAAAA)4R-amide, and the melting of these peptides is followed using CD.
C F, Chang, M H, Zehfus
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Backbone modifications in peptidic inhibitors of flaviviral proteases
Bioorganic & Medicinal Chemistry Letters, 2019The NS2B-NS3 protease is a promising target for the development of drugs against dengue virus (DENV), West Nile virus (WNV) and related flaviviruses. We report the systematic variation of the peptide backbone of the two lead compounds Bz-Arg-Lys-d-Phg-NH2 and Bz-Arg-Lys-d-Phg(OBn)-NH2.
Alexander K M H, Jakob +2 more
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Sequence-Defined Backbone Modifications Regulate Antibacterial Activity of OligoTEAs
ACS Chemical Biology, 2017In response to the urgent need for new antibiotic development strategies, antimicrobial peptides (AMPs) and other synthetic polymers are being actively investigated as promising alternatives to traditional antibiotics. Although most AMPs display lytic activity against several types of bacteria, they have poor toxicology profiles and are susceptible to ...
Mintu Porel +3 more
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Backbone modifications in oligonucleotides and peptide nucleic acid systems
Current Opinion in Structural Biology, 1995In the past year major advances have been made in the design, synthesis and characterization of two classes of modified oligonucleotides. In the first class, the phosphodiester backbone of 2'-deoxyribo-oligonucleotides has been replaced in several different ways. The second group represents a completely different type of oligonucleotide modification in
A, De Mesmaeker +3 more
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Postsynthetic Modification of DNA Phosphodiester Backbone for Photocaged DNAzyme
ACS Chemical Biology, 2015Photocaged (photoactivatable) biomolecules are powerful tools for noninvasive control of biochemical activities by light irradiation. DNAzymes (deoxyribozymes) are single-stranded oligonucleotides with a broad range of enzymatic activities. In this work, to construct photocaged DNAzymes, we developed a facile and mild postsynthetic method to ...
Xiaoyan, Wang +4 more
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Synthesis and modification of triterpenoids with two lupan backbones
Russian Journal of Bioorganic Chemistry, 2009The first derivatives containing two lupan backbones were synthesized by the interaction of betulonic acid chloride with diols (ethylene glycol and diethylene glycol) and monoethanolamine. A modification of ring A of ethylene-l,2-bis(betulonnate) led to its bis(3beta-aminopropyloxy) and bis(3,4-seco-2-cyano) derivatives.
O B, Kazakova +4 more
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Ligand-based backbone modifications for metal-chelating nucleic acids
Chemical Communications, 2007Ligands were incorporated into the backbone of DNA for nucleoside replacements, and the binding of metal ions, such as Cu2+, Pt2+ and Pd4+, was shown to influence stability of the resulting duplexes.
Megan M, Knagge, Jonathan J, Wilker
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Solid‐Phase Synthesis of Peptidomimetics with Peptide Backbone Modifications
Asian Journal of Organic Chemistry, 2021AbstractPeptidomimetics are a class of compounds with promising pharmacological properties. Peptidomimetics reduce limitations of peptides including low bioavailability, poor stability, and poor cell‐permeability. Peptide backbone modifications are a frequently used manipulation to reach desirable properties of the peptide molecules. The development of
Aizhan Abdildinova +2 more
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Photophysics of Backbone Fluorescent DNA Modifications: Reducing Uncertainties in FRET
The Journal of Physical Chemistry B, 2009We have investigated the photophysical properties of backbone fluorescent DNA modifications with the goal of reducing many of the sources of uncertainty commonly encountered in Forster resonance energy transfer (FRET) measurements. We show that backbone modifications constrain rotational motions, providing a way by which the orientation of the dye can ...
Suman, Ranjit +2 more
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