Water soluble hydrophobic peptoids via a minor backbone modification
Organic & Biomolecular Chemistry, 2018The incorporation of piperazine or homopiperazine within hydrophobic peptoid scaffolds leads to their water solubility while increasing their overall conformational order in water.
Chandra Mohan Darapaneni +2 more
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Efficient synthesis of longer Aβ peptides via removable backbone modification
Organic & Biomolecular Chemistry, 2016This paper describes a new method for the efficient chemical synthesis of longer Aβ peptides with the combination of the RBM strategy and native chemical ligation.
Chao, Zuo +5 more
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Backbone Modification of Nucleic Acids: Synthesis, Structure and Therapeutic Applications
Current Medicinal Chemistry, 2001Nucleic acids have been extensively modified by replacing the phosphodiester group or the whole sugar phosphodiester with alternative anionic, neutral and cationic structures. Several of these modified oligonucleotides exhibit improved properties including enhanced recognition and binding to RNA, duplex DNA and proteins.
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Backbone modification promotes peroxidase activity of G-quadruplex-based DNAzyme
Chemical Communications, 2012In this work we studied how backbone chemical modifications, such as 2'-O-methyl, phosphorothioate, L-form nucleotides and locked nucleic acid, on G-quadruplex based DNAzymes would affect their peroxidase activity. Our results indicate that 2'-O-methyl modification facilitates the formation of a perfectly compacted parallel structure and significantly ...
Li, Cong +8 more
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Chemical modification of charge transport in silicon backbone polymers
Synthetic Metals, 1989Abstract Charge transport in highly insulating Si backbone polymers has been studied by the Time Of Flight technique. Transit pulse shapes and the field and temperature dependence of the hole drift mobility (for many systems about 10 −4 cm 2 /Vs at 295K and E = 10 5 V/cm) have been characterized for a prototypical example, poly(methylphenylsilylene)
M.A. Abkowitz +4 more
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Structural Correlations of Backbone Modifications in Antisense Oligonucleotide Duplexes
Nucleosides and Nucleotides, 1997Abstract This article presents a collective of structural analyses concerning backbone modified oligonucleotides and various factors which correlate the conformational preference of backbone modifications with the stability of antisense duplexes.
Xiaolian Gao +3 more
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Ruthenium-catalyzed glycine-selective oxidative backbone modification of peptides
Tetrahedron Letters, 2000Abstract The reaction of N,C-protected peptides containing glycine residues with peracetic acid in the presence of a ruthenium catalyst gives α-ketoamides derived from the oxidation at the Cα position of the glycine residues selectively.
Shun-Ichi Murahashi +2 more
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Remodeling of ribosomally synthesized peptide backbones based on posttranslational modifications
Natural Product ReportsPosttranslational modifications characterized over the past decade to engage the –(NH–Cα–CO)n– repeating units in transformations are highlighted, particularly those leading to structural rearrangements by peptide backbone remodeling.
Yanqing Xue +4 more
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Trifluoromethyl Group: An Effective Xenobiotic Function for Peptide Backbone Modification
ChemInform, 2004AbstractFor Abstract see ChemInform Abstract in Full Text.
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Peptide Backbone Modifications
Current Organic Chemistry, 2008Uli Kazmaier, Jan Deska
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