Mechanism of Baclofen Inhibiting the Proliferation and Metastasis of GBM by Regulating YAP
Journal of Chemistry, 2021 This study explores the effect of baclofen on the malignant phenotype of glioblastoma (GBM) and the growth of xenograft tumors and investigates the related mechanisms, aiming to reveal the effect of baclofen on the occurrence and development of GBM.
Lin Zhu, Juan Lu, Zhijun Bao, Shiwen Guo
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Frontiers in Pharmacology, 2023 Introduction: Clinical studies on the effectiveness of Baclofen in alcohol use disorder (AUD) yielded mixed results possibly because of differential effects of the enantiomers and sex-related differences.
Jérôme Jeanblanc +16 more
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Stability Study of Baclofen in an Oral Powder Form Compounded for Pediatric Patients in Japan
Children, 2022 Baclofen is used as a skeletal muscle relaxant for multiple sclerosis patients and pediatric patients with cerebral palsy and is prescribed to pediatric patients at 0.3 to 1.0 mg/kg/dose.
Jumpei Saito +7 more
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R(+)-baclofen, but not S(-)-baclofen, alters alcohol self-administration in alcohol-preferring rats
Frontiers in Psychiatry, 2016 Racemic baclofen [(±)-baclofen] has repeatedly been reported to suppress several alcohol-motivated behaviors, including alcohol drinking and alcohol self-administration, in rats and mice.
Irene eLorrai +3 more
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Metabolic and Pharmacokinetic Differentiation of STX209 and Racemic Baclofen in Humans
Metabolites, 2012 STX209 is an exploratory drug comprising the single, active R-enantiomer of baclofen which is in later stage clinical trials for the treatment of fragile x syndrome (FXS) and autism spectrum disorders (ASD).
Raymundo Sanchez-Ponce +5 more
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Chinese Medicine, 2010 Background Chronic non-specific low back pain (LBP) is a prevalent (80%) and multi-dimensional illness. This study aims to test whether acupuncture, baclofen, or combined treatment with acupuncture and baclofen alleviates symptoms of non-specific chronic
Rastqar Ali +3 more
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Conditional gene deletion reveals functional redundancy of GABAB receptors in peripheral nociceptors in vivo [PDF]
, 2009 Background Gamma-aminobutyric acid (GABA) is an important inhibitory neurotransmitter which mainly mediates its effects on neurons via ionotropic (GABAA) and metabotropic (GABAB) receptors.
Bernhard Bettler +9 more
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Treatments for spasticity and pain in multiple sclerosis: a systematic review [PDF]
, 2003 Objectives: To identify the drug treatments currently available for the management of spasticity and pain in multiple sclerosis (MS), and to evaluate their clinical and cost-effectiveness.
Beard, S.M., Hunn, A., Wight, J.
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Comparison between baclofen and topiramate in alcohol dependence: A prospective study
Industrial Psychiatry Journal, 2019 Introduction: Baclofen and topiramate are GABAergic drugs, and both have been recommended for the treatment of alcohol dependence as anticraving agent. Several studies have demonstrated the effect of baclofen and topiramate as anticraving, but none has ...
Nimmi A Jose +3 more
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Digitization of multistep organic synthesis in reactionware for on-demand pharmaceuticals [PDF]
, 2018 Chemical manufacturing is often done at large facilities that require a sizable capital investment and then produce key compounds for a finite period. We present an approach to the manufacturing of fine chemicals and pharmaceuticals in a self-contained ...
Cronin, Leroy +6 more
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