Results 91 to 100 of about 1,155,621 (272)

Exploring new biological functions of amyloids: bacteria cell agglutination mediated by host protein aggregation.

PLoS Pathogens, 2012
Antimicrobial proteins and peptides (AMPs) are important effectors of the innate immune system that play a vital role in the prevention of infections. Recent advances have highlighted the similarity between AMPs and amyloid proteins. Using the Eosinophil
Marc Torrent, David Pulido, M Victòria Nogués, Ester Boix   +3 more
doaj   +1 more source

The Evolution of Functional Amyloids and Their Impact on Host–Microbe Interactions

Advanced Science
Amyloids are highly ordered β‐sheet‐rich structures that are well conserved across the domains of life. Amyloids have a unique repetitive structure that enables autocatalytic self‐replication.
Divya Kolli, Saroj K. Rout, Roland Riek, Matthew R. Chapman   +3 more
doaj   +1 more source

A Specific Reduction in Aβ1−42 vs. a Universal Loss of Aβ Peptides in CSF Differentiates Alzheimer's Disease From Meningitis and Multiple Sclerosis

Frontiers in Aging Neuroscience, 2018
A reduced concentration of Aβ1−42 in CSF is one of the established biomarkers of Alzheimer's disease. Reduced CSF concentrations of Aβ1−42 have also been shown in multiple sclerosis, viral encephalitis and bacterial meningitis.
Philipp Spitzer, Roland Lang, Timo J. Oberstein, Piotr Lewczuk, Piotr Lewczuk, Natalia Ermann, Hagen B. Huttner, Ilias Masouris, Johannes Kornhuber, Uwe Ködel, Juan M. Maler   +10 more
doaj   +1 more source

Accelerated Amyloid Beta Pathogenesis by Bacterial Amyloid FapC [PDF]

Biophysical Journal, 2021
Zhenzhen Zhang, Feng Ding
openaire   +1 more source

Balancing inflammation: the specific roles of serum amyloid A proteins in sterile and infectious diseases

Frontiers in Immunology
Serum Amyloid A (SAA) proteins are acute-phase reactants with critical roles in sterile and bacterial inflammation. Through in vitro and in vivo experiments, we demonstrate that SAA proteins amplify cytokine and chemokine responses during sterile ...
Tirthankar Mohanty, Katarina Miličević, Henri Göthert, Andreas Tillmann, Médea Padra, Praveen Papareddy, Heiko Herwald   +6 more
doaj   +1 more source

Bacterial Amyloids

, 2019
Peer ...
Marcoleta, Andrés, Wien, Frank, Arluison, Véronique, Lagos, Rosalba, Giraldo, R.   +4 more
openaire   +1 more source

Lipopolysaccharide Associates with Amyloid Plaques, Neurons and Oligodendrocytes in Alzheimer’s Disease Brain: A Review

Frontiers in Aging Neuroscience, 2018
This review proposes that lipopolysaccharide (LPS, found in the wall of all Gram-negative bacteria) could play a role in causing sporadic Alzheimer’s disease (AD). This is based in part upon recent studies showing that: Gram-negative E. coli bacteria can
Xinhua Zhan, Boryana Stamova, Frank R. Sharp   +2 more
doaj   +1 more source

E.coli-derived CsgA-peptides stimulate cytokine production in microglia and lead to transient changes in neocortical Aβ-levels in pre-plaque APPSWE/PS1ΔE9 and wild type mice

Brain, Behavior, & Immunity - Health
Epidemiological and pre-clinical data propose that infections can accelerate the cognitive decline in Alzheimer's disease (AD) and other dementias.
Leda Mygind, Gabriel Jensen, Victoria Neesgaard, Katrine Tækker Krohn, Serges Torres Puig, Anders Boysen, Sussanne Petersen, Kate Lykke Lambertsen, Athanasios Metaxas, Michael Kemp, Jakob Møller-Jensen, Bente Finsen   +11 more
doaj   +1 more source

USP25 inhibition ameliorates Alzheimer’s pathology through the regulation of APP processing and Aβ generation

The Journal of Clinical Investigation, 2022
Down syndrome (DS), or trisomy 21, is one of the critical risk factors for early-onset Alzheimer’s disease (AD), implicating key roles for chromosome 21–encoded genes in the pathogenesis of AD. We previously identified a role for the deubiquitinase USP25,
Qiuyang Zheng, Beibei Song, Guilin Li, Fang Cai, Meiling Wu, Yingjun Zhao, LuLin Jiang, Tiantian Guo, Mingyu Shen, Huan Hou, Ying Zhou, Yini Zhao, Anjie Di, Lishan Zhang, Fanwei Zeng, Xiu-Fang Zhang, Hong Luo, Xian Zhang, Hongfeng Zhang, Zhiping Zeng, Timothy Y. Huang, Chen Dong, Hong Qing, Yun Zhang, Qing Zhang, Xu Wang, Yili Wu, Huaxi Xu, Weihong Song, Xin Wang   +29 more
doaj   +1 more source

Multivariate Analysis of Hematological Stress Biomarkers and Welfare Domains in Organic and Intensive Pig Farming in Italy: A Pilot Study

Animal Research and One Health, EarlyView.
Intensive or organic farming systems may expose pigs to management or environmental challenges. Our preliminary results concluded that organic farming might enhance adaptive immune function, showing that improvements in welfare can translate into measurable immunological benefits, based on the correlation between welfare assessment and physiological ...
Dorotea Ippolito, Talal Hassan, Antonio Marco Maisano, Stefania Bergagna, Cecilia Guasco, Barbara Miniscalco, Martina Tarantola, Elena Colombino, Claudio Caruso, Ahsan Muhammad, Silvia Mioletti, Laura Tomassone, Massimiliano Tursi, Cristina Vercelli, Giovanni Loris Alborali, Maria Teresa Capucchio   +15 more
wiley   +1 more source