Results 21 to 30 of about 92,288 (249)
Sequence Determinants of Bacterial Amyloid Formation [PDF]
Journal of Molecular Biology, 2008 Amyloids are proteinaceous fibers commonly associated with neurodegenerative diseases and prion-based encephalopathies. Many different polypeptides can form amyloid fibers, leading to the suggestion that amyloid is a primitive main chain-dominated structure.
Xuan, Wang, Matthew R, Chapman
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Small molecule targeting amyloid fibrils inhibits Streptococcus mutans biofilm formation
AMB Express, 2021 Amyloid fibrils are important scaffold in bacterial biofilms. Streptococcus mutans is an established cariogenic bacteria dwelling within biofilms, and C123 segment of P1 protein is known to form amyloid fibrils in S.
Yuanyuan Chen +4 more
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Frontiers in Pharmacology, 2022 Emerging evidence from both clinical studies and animal models indicates the importance of the interaction between the gut microbiome and the brain in the pathogenesis of neurodegenerative diseases (NDs).
Chenyin Wang, Chaogu Zheng
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Microbiome or Infections: Amyloid-Containing Biofilms as a Trigger for Complex Human Diseases
Frontiers in Immunology, 2021 The human microbiota is the community of microorganisms that live upon or within their human host. The microbiota consists of various microorganisms including bacteria, fungi, viruses, and archaea; the gut microbiota is comprised mostly of bacteria. Many
Amanda L. Miller +3 more
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Structure of the nonameric bacterial amyloid secretion channel. [PDF]
Proc Natl Acad Sci U S A, 2014 Significance Numerous bacteria produce a unique class of “functional” amyloids termed curli that are important for the fitness of the organism by mediating biofilm formation, host cell adhesion, and colonization on inert surfaces. Here, we report the crystal structure of CsgG, a lipoprotein that forms a secretion channel for curli subunits in
Cao B +5 more
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Epigallocatechin Gallate Remodelling of Hfq Amyloid-Like Region Affects Escherichia coli Survival
Pathogens, 2018 Hfq is a pleiotropic regulator that has key roles in the control of genetic expression. The protein noticeably regulates translation efficiency and RNA decay in Gram-negative bacteria, due to the Hfq-mediated interaction between small regulatory ...
David Partouche +7 more
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Biomolecules, 2019 Self-assembly of proteins to β-sheet rich amyloid fibrils is commonly observed in various neurodegenerative diseases. However, amyloid also occurs in the extracellular matrix of bacterial biofilm, which protects bacteria from environmental stress ...
Zahra Najarzadeh +11 more
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Serum amyloid P component is an essential element of resistance against Aspergillus fumigatus
Nature Communications, 2021 Serum Amyloid P is a humoral component with established roles in the response to bacterial infection and regulation of tissue remodeling. Here the authors provide evidence to a further crucial role of serum amyloid P in the context of fungal pathogen ...
Andrea Doni +21 more
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mBio, 2023 Staphylococcus aureus secretes phenol-soluble modulins (PSMs), a family of small, amphipathic, secreted peptides with multiple biologic activities. Community-acquired S.
Xiaogang Wang +5 more
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Bacterial inclusion bodies are industrially exploitable amyloids [PDF]
FEMS Microbiology Reviews, 2018 Understanding the structure, functionalities and biology of functional amyloids is an issue of emerging interest. Inclusion bodies, namely protein clusters formed in recombinant bacteria during protein production processes, have emerged as unanticipated, highly tunable models for the scrutiny of the physiology and architecture of functional amyloids ...
Ario de Marco +9 more
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