Results 21 to 30 of about 1,155,621 (272)
Frontiers in Cellular and Infection Microbiology, 2022 The bacterial amyloid curli, produced by Enterobacteriales including Salmonella species and Escherichia coli, is implicated in the pathogenesis of several complex autoimmune diseases.
Kaitlyn Grando +6 more
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Small molecule targeting amyloid fibrils inhibits Streptococcus mutans biofilm formation
AMB Express, 2021 Amyloid fibrils are important scaffold in bacterial biofilms. Streptococcus mutans is an established cariogenic bacteria dwelling within biofilms, and C123 segment of P1 protein is known to form amyloid fibrils in S.
Yuanyuan Chen +4 more
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Microbiome or Infections: Amyloid-Containing Biofilms as a Trigger for Complex Human Diseases
Frontiers in Immunology, 2021 The human microbiota is the community of microorganisms that live upon or within their human host. The microbiota consists of various microorganisms including bacteria, fungi, viruses, and archaea; the gut microbiota is comprised mostly of bacteria. Many
Amanda L. Miller +3 more
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Sequence Determinants of Bacterial Amyloid Formation [PDF]
Journal of Molecular Biology, 2008 Amyloids are proteinaceous fibers commonly associated with neurodegenerative diseases and prion-based encephalopathies. Many different polypeptides can form amyloid fibers, leading to the suggestion that amyloid is a primitive main chain-dominated structure.
Xuan, Wang, Matthew R, Chapman
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Biomolecules, 2019 Self-assembly of proteins to β-sheet rich amyloid fibrils is commonly observed in various neurodegenerative diseases. However, amyloid also occurs in the extracellular matrix of bacterial biofilm, which protects bacteria from environmental stress ...
Zahra Najarzadeh +11 more
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Frontiers in Pharmacology, 2022 Emerging evidence from both clinical studies and animal models indicates the importance of the interaction between the gut microbiome and the brain in the pathogenesis of neurodegenerative diseases (NDs).
Chenyin Wang, Chaogu Zheng
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Serum amyloid P component is an essential element of resistance against Aspergillus fumigatus
Nature Communications, 2021 Serum Amyloid P is a humoral component with established roles in the response to bacterial infection and regulation of tissue remodeling. Here the authors provide evidence to a further crucial role of serum amyloid P in the context of fungal pathogen ...
Andrea Doni +21 more
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Epigallocatechin Gallate Remodelling of Hfq Amyloid-Like Region Affects Escherichia coli Survival
Pathogens, 2018 Hfq is a pleiotropic regulator that has key roles in the control of genetic expression. The protein noticeably regulates translation efficiency and RNA decay in Gram-negative bacteria, due to the Hfq-mediated interaction between small regulatory ...
David Partouche +7 more
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The role of tandem repeats in bacterial functional amyloids
Journal of Structural Biology, 2023 Repetitivity and modularity of proteins are two related notions incorporated into multiple evolutionary concepts. We discuss whether they may also be essential for functional amyloids. Amyloids are proteins that create very regular and usually highly insoluble fibrils, which are often associated with neurodegeneration.
Alicja W. Nowakowska +3 more
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mBio, 2023 Staphylococcus aureus secretes phenol-soluble modulins (PSMs), a family of small, amphipathic, secreted peptides with multiple biologic activities. Community-acquired S.
Xiaogang Wang +5 more
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