Results 71 to 80 of about 92,288 (249)

Sex as a biological variable in nonclinical studies: Bridging scientific rigor, animal welfare, and regulatory expectations

Animal Models and Experimental Medicine, EarlyView.
Sex as a biological variable (SABV) is a critical determinant of pharmacokinetics, pharmacodynamics, and toxicity in nonclinical studies. This review highlights how inappropriate neglect of sex differences compromises animal welfare, scientific reproducibility, and regulatory compliance.
Kenta Onuma, Masaki Watanabe, Nobuya Sasaki   +2 more
wiley   +1 more source

Structural Insights into Curli CsgA Cross-β Fibril Architecture Inspire Repurposing of Anti-amyloid Compounds as Anti-biofilm Agents.

PLoS Pathogens, 2019
Curli amyloid fibrils secreted by Enterobacteriaceae mediate host cell adhesion and contribute to biofilm formation, thereby promoting bacterial resistance to environmental stressors.
Sergei Perov, Ofir Lidor, Nir Salinas, Nimrod Golan, Einav Tayeb-Fligelman, Maya Deshmukh, Dieter Willbold, Meytal Landau   +7 more
doaj   +1 more source

Exploring new biological functions of amyloids: bacteria cell agglutination mediated by host protein aggregation.

PLoS Pathogens, 2012
Antimicrobial proteins and peptides (AMPs) are important effectors of the innate immune system that play a vital role in the prevention of infections. Recent advances have highlighted the similarity between AMPs and amyloid proteins. Using the Eosinophil
Marc Torrent, David Pulido, M Victòria Nogués, Ester Boix   +3 more
doaj   +1 more source

Polyphenol‐Based Biomaterials Against Cancer Radio/Chemotherapy‐Induced Intestinal Toxicity

Advanced NanoBiomed Research, EarlyView.
Radiotherapy/chemotherapy often causes intestinal toxicity, impairing cancer patients’ quality of life and treatment efficacy. Polyphenols protect against this injury via multiple mechanisms, but face oral use limitations. This review outlines their protective mechanisms and delivery challenges, highlighting recent oral delivery advances and future ...
Jixu Lu, Jing Chen, Ji Zhu, Lixin Ru, Dongxiao Zhang   +4 more
wiley   +1 more source

The Evolution of Functional Amyloids and Their Impact on Host–Microbe Interactions

Advanced Science
Amyloids are highly ordered β‐sheet‐rich structures that are well conserved across the domains of life. Amyloids have a unique repetitive structure that enables autocatalytic self‐replication.
Divya Kolli, Saroj K. Rout, Roland Riek, Matthew R. Chapman   +3 more
doaj   +1 more source

A Specific Reduction in Aβ1−42 vs. a Universal Loss of Aβ Peptides in CSF Differentiates Alzheimer's Disease From Meningitis and Multiple Sclerosis

Frontiers in Aging Neuroscience, 2018
A reduced concentration of Aβ1−42 in CSF is one of the established biomarkers of Alzheimer's disease. Reduced CSF concentrations of Aβ1−42 have also been shown in multiple sclerosis, viral encephalitis and bacterial meningitis.
Philipp Spitzer, Roland Lang, Timo J. Oberstein, Piotr Lewczuk, Piotr Lewczuk, Natalia Ermann, Hagen B. Huttner, Ilias Masouris, Johannes Kornhuber, Uwe Ködel, Juan M. Maler   +10 more
doaj   +1 more source

Nanomaterial‐Mediated Near‐Infrared Photothermal Neuromodulation for Neurologic Disorders

Advanced NanoBiomed Research, EarlyView.
This review summarizes how near‐infrared light activates photothermal nanomaterials to enable noninvasive neuromodulation with high spatiotemporal precision. It elucidates the underlying mechanisms, explores targeted therapeutic applications for neurological disorders, discusses integration with optogenetics and biosensors, and addresses future ...
Ting‐Ting Zeng, Yu‐Ge Wang, Ya‐Bing Zhang, Yuan‐Xin Bai, Si‐Tong Lin, Ting‐Ting Zhu, Yan‐Bo Zhou, Wei‐Tong Pan, Pan‐Miao Liu, Jian‐Jun Yang   +9 more
wiley   +1 more source

Accelerated Amyloid Beta Pathogenesis by Bacterial Amyloid FapC [PDF]

Biophysical Journal, 2021
Zhenzhen Zhang, Feng Ding
openaire   +1 more source

Balancing inflammation: the specific roles of serum amyloid A proteins in sterile and infectious diseases

Frontiers in Immunology
Serum Amyloid A (SAA) proteins are acute-phase reactants with critical roles in sterile and bacterial inflammation. Through in vitro and in vivo experiments, we demonstrate that SAA proteins amplify cytokine and chemokine responses during sterile ...
Tirthankar Mohanty, Katarina Miličević, Henri Göthert, Andreas Tillmann, Médea Padra, Praveen Papareddy, Heiko Herwald   +6 more
doaj   +1 more source

Bacterial Amyloids

, 2019
Amyloids are supramolecular protein assemblies based on fibrillar arrangements of β- sheets that were first found as linked to neurodegenerative and systemic human diseases. However, there is now overwhelming evidence on alternative roles of amyloids as functional assemblies and as epigenetic determinants of beneficial traits, both in ...
Marcoleta, Andrés, Wien, Frank, Arluison, Véronique, Lagos, Rosalba, Giraldo, R.   +4 more
openaire   +1 more source