Pattern of amino acid substitutions in transmembrane domains of β-barrel membrane proteins for detecting remote homologs in bacteria and mitochondria. [PDF]
PLoS ONE, 2011 β-barrel membrane proteins play an important role in controlling the exchange and transport of ions and organic molecules across bacterial and mitochondrial outer membranes.
David Jimenez-Morales, Jie Liang
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Mechanisms of Protein Export across the Bacterial Outer Membrane [PDF]
Journal of Bacteriology, 2005 Gram-negative bacteria secrete a wide range of proteins whose functions include biogenesis of organelles, such as pili and flagella; nutrient acquisition; virulence; and efflux of drugs and other toxins. Export of these proteins to the bacterial surface involves transport across the inner membrane (IM), periplasm, and outer membrane (OM) of the cell ...
Maria, Kostakioti +3 more
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HELICOBACTER PYLORI OIPA VIRULENCE GENE AS A MOLECULAR MARKER OF SEVERE GASTROPATHIES [PDF]
Arquivos de GastroenterologiaBackground: Helicobacter pylori is an etiologic agent of gastroduodenal diseases. The microorganism, considered a type I carcinogen, affects about 50% of the global population. H.
Diogo Nery MACIEL +4 more
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Detection of the babA2 adhesin gene in Helicobacter pylori clinical isolates and correlation with upper gastrointestinal diseases [PDF]
Anais da Academia Brasileira de CiênciasHelicobacter pylori is an oncobacteria that infects more than half of the world’s population. Adhesins are virulence factors that are essential for the microorganism to bind to the gastric mucosa, such as the BabA adhesion protein, which is associated ...
DIOGO NERY MACIEL +5 more
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Interactions between folding factors and bacterial outer membrane proteins [PDF]
Molecular Microbiology, 2005 SummaryThe outer membrane is the first line of contact between Gram‐negative bacteria and their external environment. Embedded in the outer membrane are integral outer membrane proteins (OMPs) that perform a diverse range of tasks. OMPs are synthesized in the cytoplasm and are translocated across the inner membrane and probably diffuse through the ...
Mogensen, Jesper E., Otzen, Daniel E.
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Super-Resolution Imaging of Protein Secretion Systems and the Cell Surface of Gram-Negative Bacteria
Frontiers in Cellular and Infection Microbiology, 2017 Gram-negative bacteria have a highly evolved cell wall with two membranes composed of complex arrays of integral and peripheral proteins, as well as phospholipids and glycolipids.
Sachith D. Gunasinghe +4 more
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Outer membrane biogenesis in Helicobacter pylori: A deviation from the paradigm
Frontiers in Cellular and Infection Microbiology, 2012 The bacterial pathogen Helicobacter pylori is capable of colonizing the gastric mucosa of the human stomach using a variety of factors associated with or secreted from its outer membrane (OM).
George W. Liechti, Joanna B. Goldberg
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Stress-Responsive Periplasmic Chaperones in Bacteria
Frontiers in Molecular Biosciences, 2021 Periplasmic proteins are involved in a wide range of bacterial functions, including motility, biofilm formation, sensing environmental cues, and small-molecule transport. In addition, a wide range of outer membrane proteins and proteins that are secreted
Hyunhee Kim +4 more
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β-Barrel Assembly Machinery (BAM) Complex as Novel Antibacterial Drug Target
Molecules, 2023 The outer membrane of Gram-negative bacteria is closely related to the pathogenicity and drug resistance of bacteria. Outer membrane proteins (OMPs) are a class of proteins with important biological functions on the outer membrane.
Qian Xu, Min Guo, Feiyuan Yu
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Bacterial Outer Membranes and Interactions with Membrane Proteins [PDF]
Biophysical Journal, 2015 Because the bacteria's outer membrane (OM) acts as an effective barrier against the permeation of both hydrophobic and hydrophilic compounds, gram-negative cell permeation is one of the biggest challenges to the discovery of novel antibiotics for bacterial infections and antibiotic resistance worldwide.
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