Results 51 to 60 of about 202,274 (318)

Construction of a bacterial surface display system based on outer membrane protein F

Microbial Cell Factories, 2019
Background Bacterial surface display systems were developed to surface expose heterologous proteins or peptides for different applications, such as peptide libraries screening and live bacterial vaccine design.
Tingting Chen, Kaihang Wang, Xin Chi, Lizhi Zhou, Jiajia Li, Liqin Liu, Qingbing Zheng, Yingbin Wang, Hai Yu, Ying Gu, Jun Zhang, Shaowei Li, Ningshao Xia   +12 more
doaj   +1 more source

The Landscape of Pseudomonas aeruginosa Membrane-Associated Proteins

Cells, 2020
Background: Pseudomonas aeruginosa cell envelope-associated proteins play a relevant role in infection mechanisms. They can contribute to the antibiotic resistance of the bacterial cells and be involved in the interaction with host cells.
Sara Motta, Davide Vecchietti, Alessandra M. Martorana, Pietro Brunetti, Giovanni Bertoni, Alessandra Polissi, Pierluigi Mauri, Dario Di Silvestre   +7 more
doaj   +1 more source

Defining key roles for auxiliary proteins in an ABC transporter that maintains bacterial outer membrane lipid asymmetry

eLife, 2016
In Gram-negative bacteria, lipid asymmetry is critical for the function of the outer membrane (OM) as a selective permeability barrier, but how it is established and maintained is poorly understood.
Shuhua Thong, Bilge Ercan, F. Torta, Zhen Yang Fong, H. Y. A. Wong, M. Wenk, Shu-Sin Chng   +6 more
semanticscholar   +1 more source

Chaperone Spy Protects Outer Membrane Proteins from Folding Stress via Dynamic Complex Formation

mBio, 2021
Outer membrane proteins (OMPs) play critical roles in bacterial pathogenicity and provide a new niche for antibiotic development. A comprehensive understanding of the OMP quality control network will strongly impact antimicrobial discovery.
Wei He, Gangjin Yu, Tianpeng Li, Ling Bai, Yuanyuan Yang, Zixiao Xue, Yonghao Pang, Dana Reichmann, Sebastian Hiller, Lichun He, Maili Liu, Shu Quan   +11 more
doaj   +1 more source

Mucin adsorbed by E. coli can affect neutrophil activation in vitro

FEBS Open Bio, 2020
Bacteria colonizing human intestine adhere to the gut mucosa and avoid the innate immune system. We previously demonstrated that Escherichia coli isolates can adsorb mucin from a diluted solution in vitro.
Elena Mikhalchik, Nadezhda Balabushevich, Tatiana Vakhrusheva, Alexey Sokolov, Julia Baykova, Daria Rakitina, Petr Scherbakov, Sergey Gusev, Alexander Gusev, Zaira Kharaeva, Olga Bukato, Olga Pobeguts   +11 more
doaj   +1 more source

The Effect of Lipopolysaccharide Core Oligosaccharide Size on the Electrostatic Binding of Antimicrobial Proteins to Models of the Gram Negative Bacterial Outer Membrane

Langmuir, 2016
Understanding the electrostatic interactions between bacterial membranes and exogenous proteins is crucial to designing effective antimicrobial agents against Gram-negative bacteria.
L. Clifton, F. Ciesielski, M. Skoda, Nicoló Paracini, S. Holt, J. Lakey   +5 more
semanticscholar   +1 more source

The participation of outer membrane proteins in the bacterial sensitivity to nanosilver

Postępy Higieny i Medycyny Doświadczalnej, 2016
The presented study is to analyze the participation of outer membrane proteins of Gram- negative bacteria in sensitivity to silver nanomaterials. The mechanism of interaction of silver with the bacterial cell is best described in this group of microorganisms.
Anna Kędziora, Eva Krzyżewska, Bartłomiej Dudek, Gabriela Bugla-Płoskońska   +3 more
openaire   +3 more sources

Reconstitution of a nanomachine driving the assembly of proteins into bacterial outer membranes [PDF]

Nature Communications, 2014
In biological membranes, various protein secretion devices function as nanomachines, and measuring the internal movements of their component parts is a major technological challenge. The translocation and assembly module (TAM) is a nanomachine required for virulence of bacterial pathogens. We have reconstituted a membrane containing the TAM onto a gold
Shen, Hsin-Hui, Leyton, Denisse, Shiota, Takuya, Belousoff, Matthew J, Noinaj, Nicholas, Lu, Jingxiong, Holt, Stephen A., Tan, Kershing, Selkrig, Joel, Webb, Chaille T., Buchanan, Susan K., Martin, Lisandra, Lithgow, Trevor   +12 more
openaire   +4 more sources

Analyzing the molecular mechanism of lipoprotein localization in Brucella

Frontiers in Microbiology, 2015
Bacterial lipoproteins possess comprehensive structure and functionality, ranging from bacterial physiology to pathogenic processes. As such many lipoproteins, originating from Brucella are exploited as potential vaccines to countermeasure brucellosis ...
Shivani eGoolab, Shivani eGoolab, Robyn Lindsay Roth, Henriette evan Heerden, Michael Craig Crampton   +4 more
doaj   +1 more source

Driving Forces for Protein Secretion Across the Bacterial Outer Membrane [PDF]

Biophysical Journal, 2014
Autotransporters are a large and diverse class of monomeric virulence proteins secreted from Gram-negative bacterial pathogens. Secretion across the outer membrane is facilitated by the C-terminal translocator domain that creates a pore in the outer membrane, through which the N-terminal passenger (the functional, extracellular part of the protein ...
Igor Drobnak, Patricia L. Clark
openaire   +2 more sources