Results 51 to 60 of about 441,842 (342)

Antibiotics targeting bacterial protein synthesis reduce the lytic activity of bacteriophages

Virus Research, 2022
Combination therapy of bacteriophages and antibiotics requires careful selection of specific antibiotics as it is crucial towards determining the success of phage therapy to treat multiple drug-resistant bacterial infections.
Medhavi Vashisth, Shikha Yashveer, Taruna Anand, Nitin Virmani, Bidhan Chand Bera, Rajesh Kumar Vaid   +5 more
doaj   +1 more source

Personalized bacteriophage therapy outcomes for 100 consecutive cases: a multicentre, multinational, retrospective observational study

Nature Microbiology
In contrast to the many reports of successful real-world cases of personalized bacteriophage therapy (BT), randomized controlled trials of non-personalized bacteriophage products have not produced the expected results.
J. Pirnay, S. Djebara, Griet Steurs, Johann Griselain, C. Cochez, Steven De Soir, T. Glonti, An Spiessens, Emily Vanden Berghe, Sabrina Green, J. Wagemans, C. Lood, Eddie Schrevens, N. Chanishvili, M. Kutateladze, Mathieu de Jode, P. Ceyssens, J. Draye, G. Verbeken, D. De Vos, T. Rose, J. Onsea, Brieuc Van Nieuwenhuyse, Kim Win Willem-Jan Dimitri Olga Anaïs Angel Adrien Ann Pang Metsemakers Van der Linden Chatzis Eskenazi L, Kim Win Pang, W. Metsemakers, D. Van der Linden, Olga Chatzis, Anaïs Eskenazi, Angel Lopez, Adrien De Voeght, A. Rousseau, Anne Tilmanne, Daphné Vens, Jean Gérain, Brice Layeux, E. Vlieghe, I. Baar, S. Van Ierssel, J. Van Laethem, Julien Guiot, Sophie De Roock, S. Jennes, S. Uyttebroek, L. Van Gerven, Peter W. Hellings, L. Dupont, Y. Debaveye, D. Devolder, Isabel Spriet, P. De Munter, M. Depypere, Michiel Vanfleteren, Olivier Cornu, Stijn Verhulst, T. Boiy, Stoffel Lamote, Thibaut van Zele, Grégoire Wieërs, Cécile Courtin, D. Lebeaux, Jacques Sartre, Tristan Ferry, F. Laurent, Kevin Paul, M. Di Luca, Stefan Gottschlich, T. Tkhilaishvili, N. Cesta, K. Racenis, Telma Barbosa, L. López-Cortés, Maria Tomás, Martin Hübner, Truong-Thanh Pham, Paul Nagtegaal, J. ten Oever, Johannes Daniels, Maartje Loubert, Ghariani Iheb, Joshua Jones, Lesley M L Hall, Matthew J Young, Nana Marina Yigang Christine Johannes Ronen Ran Joana V Balarjishvili Tediashvili Tong Rohde Wittmann Haza, N. Balarjishvili, M. Tediashvili, Yigang Tong, C. Rohde, Johannes Wittmann, Ronen Hazan, Ran Nir-Paz, Joana Azeredo, Victor N. Krylov, D. Cameron, M. Pitton, Y. Que, G. Resch, S. McCallin, Matthew Dunne, S. Kilcher, P. Soentjens, R. Lavigne, M. Merabishvili   +102 more
semanticscholar   +1 more source

Dynamics of Bacteriophage Genome Ejection In Vitro and In Vivo

, 2010
Bacteriophages, phages for short, are viruses of bacteria. The majority of phages contain a double-stranded DNA genome packaged in a capsid at a density of ~500 mg/ml. This high density requires substantial compression of the normal B form helix, leading
Molineux, Ian J., Panja, Debabrata
core   +1 more source

Molecular bases and role of viruses in the human microbiome. [PDF]

, 2014
Viruses are dependent biological entities that interact with the genetic material of most cells on the planet, including the trillions within the human microbiome.
Abeles, Shira R, Pride, David T
core   +1 more source

Resistance Development to Bacteriophages Occurring during Bacteriophage Therapy

Viruses, 2018
Bacteriophage (phage) therapy, i.e., the use of viruses that infect bacteria as antimicrobial agents, is a promising alternative to conventional antibiotics.
Frank Oechslin
semanticscholar   +1 more source

A Cryptic Non-Inducible Prophage Confers Phage-Immunity on the Streptococcus thermophilus M17PTZA496 [PDF]

, 2018
open9openda Silva Duarte, Vinícius; Giaretta, Sabrina; Campanaro, Stefano; Treu, Laura; Armani, Andrea; Tarrah, Armin; Oliveira de Paula, Sérgio; Giacomini, Alessio; Corich, Vivianada Silva Duarte, Vinícius; Giaretta, Sabrina; Campanaro, Stefano; Treu ...

core   +1 more source

Highly Sensitive Bacteriophage-Based Detection of Brucella abortus in Mixed Culture and Spiked Blood

Viruses, 2017
For decades, bacteriophages (phages) have been used for Brucella species identification in the diagnosis and epidemiology of brucellosis. Traditional Brucella phage typing is a multi-day procedure including the isolation of a pure culture, a step that ...
Kirill V. Sergueev, Andrey A. Filippov, Mikeljon P. Nikolich   +2 more
doaj   +1 more source

Eradication of a multi-drug resistant, carbapenemase-producing Klebsiella pneumoniae isolate following oral and intra-rectal therapy with a custom-made, lytic bacteriophage preparation.

Clinical Infectious Diseases, 2020
In July 2017, a patient presented colonization with a multi-drug resistant, carbapenemase (KPC-3)-producing Klebsiella pneumoniae isolate. A custom-made, lytic bacteriophage preparation was administered to the patient in December 2017, with subsequent ...
M. Corbellino, N. Kieffer, M. Kutateladze, N. Balarjishvili, Lika Leshkasheli, L. Askilashvili, G. Tsertsvadze, S. Rimoldi, D. Nizharadze, N. Hoyle, L. Nadareishvili, S. Antinori, C. Pagani, D. Scorza, Ai Ling Loredana Romanò, S. Ardizzone, P. Danelli, M. Gismondo, M. Galli, P. Nordmann, L. Poirel   +20 more
semanticscholar   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Recent advances in bacteriophage-based therapeutics: Insight into the post-antibiotic era

Acta Pharmaceutica Sinica B, 2022
Antibiotic resistance is one of the biggest threats to global health, as it can make the treatment of bacterial infections in humans difficult owing to their high incidence rate, mortality, and treatment costs.
Hao Ling, Xinyu Lou, Qiuhua Luo, Zhonggui He, Mengchi Sun, Jin Sun   +5 more
doaj   +1 more source