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Bacteriophages in the gastrointestinal tract and their implications
The gut microbiota plays an essential role in health and disease of humans. Bacteriophages are the most abundant members of the gut virobiota and display great diversity.
Marzanna Łusiak-Szelachowska+4 more
doaj +1 more source
With concern growing over antibiotics resistance, the use of bacteriophages to combat resistant bacteria has been suggested as an alternative strategy with which to enable the selective control of targeted pathogens.
Sang-Guen Kim+9 more
doaj +1 more source
ΦCrAss001 represents the most abundant bacteriophage family in the human gut and infects Bacteroides intestinalis [PDF]
peer-reviewedCrAssphages are an extensive and ubiquitous family of tailed bacteriophages, predicted to infect bacteria of the order Bacteroidales. Despite being found in ~50% of individuals and representing up to 90% of human gut viromes, members of this
Draper, Lorraine A.+6 more
core +4 more sources
Genome landscapes and bacteriophage codon usage [PDF]
Across all kingdoms of biological life, protein-coding genes exhibit unequal usage of synonmous codons. Although alternative theories abound, translational selection has been accepted as an important mechanism that shapes the patterns of codon usage in prokaryotes and simple eukaryotes.
arxiv +1 more source
Antibiotic resistance represents an urgent and unresolved issue due to a rapid spread of multidrug-resistance organisms (MDROs). An alternative approach is the medical use of bacteriophages which have selective and lytic activity against specific ...
K. M. Bagandova+8 more
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Spreading dynamics of an infection in a growing population [PDF]
Bacteriophages spreading through populations of bacteria offer relatively simple, tuneable systems for testing mathematical models of range expansion. However, such models typically assume a static state into which to expand, which is not generally valid for bacterial-bacteriophage populations, where both the host (bacteria) and the infectious agent ...
arxiv
Application of bacteriophages [PDF]
The emergence of antibiotic-resistant bacteria and decrease in the discovery rate of novel antibiotics takes mankind back to the ‘pre-antibiotic era' and search for alternative treatments. Bacteriophages have been one of promising alternative agents which can be utilised for medicinal and biological control purposes in agriculture and related fields ...
Aminov, Rustam+14 more
openaire +4 more sources
A Single-Molecule Hershey-Chase Experiment [PDF]
Ever since Hershey and Chase used phages to establish DNA as the carrier of genetic information in 1952, the precise mechanisms of phage DNA translocation have been a mystery. While bulk measurements have set a time scale for in vivo DNA translocation during bacteriophage infection, measurements of DNA ejection by single bacteriophages have only been ...
arxiv +1 more source
A Cryptic Non-Inducible Prophage Confers Phage-Immunity on the Streptococcus thermophilus M17PTZA496 [PDF]
open9openda Silva Duarte, Vinícius; Giaretta, Sabrina; Campanaro, Stefano; Treu, Laura; Armani, Andrea; Tarrah, Armin; Oliveira de Paula, Sérgio; Giacomini, Alessio; Corich, Vivianada Silva Duarte, Vinícius; Giaretta, Sabrina; Campanaro, Stefano; Treu ...
core +1 more source
Ethics framework for treatment use of investigational drugs
Background Expanded access is the use of investigational drugs (IDs) outside of clinical trials. Generally it is performed in patients with serious and life-threatening diseases who cannot be treated satisfactorily with authorized drugs.
Jan Borysowski, Andrzej Górski
doaj +1 more source