A mechanical model of bacteriophage DNA ejection [PDF]
, 2017 Single molecule experiments on bacteriophages show an exponential scaling for the dependence of mobility on the length of DNA within the capsid. It has been suggested that this could be due to the "capstan mechanism" -- the exponential amplification of friction forces that result when a rope is wound around a cylinder as in a ship's capstan.
arxiv +1 more source
Ion-dependent DNA Configuration in Bacteriophage Capsids [PDF]
, 2020 Bacteriophages densely pack their long dsDNA genome inside a protein capsid. The conformation of the viral genome inside the capsid is consistent with a hexagonal liquid crystalline structure. Experiments have confirmed that the details of the hexagonal packing depend on the electrochemistry of the capsid and its environment. In this work, we propose a
arxiv +1 more source
Bacteriophages: Protagonists of a Post-Antibiotic Era
Antibiotics, 2018 Despite their long success for more than half a century, antibiotics are currently under the spotlight due to the emergence of multidrug-resistant bacteria.
P. Domingo-Calap, J. Delgado-Martínez
semanticscholar +1 more source
Bacteriophages—a new hope or a huge problem in the food industry
AIMS Microbiology, 2019 Bacteriophages are viruses that are ubiquitous in nature and infect only bacterial cells. These organisms are characterized by high specificity, an important feature that enables their use in the food industry.
Marzena Połaska, B. Sokołowska
semanticscholar +1 more source
The disparate effects of bacteriophages on antibiotic-resistant bacteria
Emerging Microbes and Infections, 2018 Faced with the crisis of multidrug-resistant bacteria, bacteriophages, viruses that infect and replicate within bacteria, have been reported to have both beneficial and detrimental effects with respect to disease management.
C. Torres-Barceló
semanticscholar +1 more source
A proposed integrated approach for the preclinical evaluation of phage therapy in Pseudomonas infections [PDF]
, 2016 Bacteriophage therapy is currently resurging as a potential complement/alternative to antibiotic treatment. However, preclinical evaluation lacks streamlined approaches.
Arabski, Michal +13 more
core +2 more sources
Integrative omics analysis of Pseudomonas aeruginosa virus PA5oct highlights the molecular complexity of jumbo phages [PDF]
, 2020 Pseudomonas virus vB_PaeM_PA5oct is proposed as a model jumbo bacteriophage to investigate phage-bacteria interactions and is a candidate for phage therapy applications.
Blasdel, Bob G. +9 more
core +1 more source
Role of osmotic and hydrostatic pressures in bacteriophage genome ejection [PDF]
Phys. Rev. E 87, 022114 (2013), 2012 A critical step in the bacteriophage life cycle is genome ejection into host bacteria. The ejection process for double-stranded DNA phages has been studied thoroughly \textit{in vitro}, where after triggering with the cellular receptor the genome ejects into a buffer.
arxiv +1 more source
BMC Research Notes, 2020 This study was conducted to isolate and characterize lytic bacteriophages for pathogenic Escherichia coli from chicken and beef offal, and analyze their capability as biocontrol for several foodborne pathogens.
Celosia Lukman +3 more
semanticscholar +1 more source
Effective elimination of Staphylococcal contamination from hospital surfaces by a bacteriophage-probiotic sanitation strategy: a monocentric study. [PDF]
, 2019 Persistent contamination of hospital surfaces and antimicrobial resistance (AMR) are recognized major causes of healthcare-associated infections (HAI). We recently showed that a probiotic-based sanitation (PCHS) can stably decrease surface pathogens and ...
BISI, Matteo +6 more
core +1 more source