Results 51 to 60 of about 72,638 (303)

Ethics framework for treatment use of investigational drugs

BMC Medical Ethics, 2020
Background Expanded access is the use of investigational drugs (IDs) outside of clinical trials. Generally it is performed in patients with serious and life-threatening diseases who cannot be treated satisfactorily with authorized drugs.
Jan Borysowski, Andrzej Górski
doaj   +1 more source

Bacteriophages and the One Health Approach to Combat Multidrug Resistance: Is This the Way?

, 2020
Antimicrobial resistance necessitates action to reduce and eliminate infectious disease, ensure animal and human health, and combat emerging diseases.
Mary Garvey
core   +1 more source

Salmonella lipopolysaccharide‐containing supported lipid bilayers as platforms to study bacteriophage interactions

FEBS Letters, EarlyView.
We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace, Alyssa Borges, Charles Arnaud, Tove Karlsson, Nina K. Bröker, Stefanie Barbirz, Marta Bally   +6 more
wiley   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Efficacy of a Salmonella Bacteriophage Cocktail Against Multidrug‐Resistant Salmonella Isolates From Clinical and Food Samples

Health Science Reports
Introduction Salmonella is a significant foodborne pathogen responsible for severe gastroenteritis and systemic infections in humans and animals.
Taras Gabisonia, Manana Loladze, Maia Zarnadze, Natia Tamarashvili, Natela Chakhunashvili, Manana Nadiradze, Maia Alibegashvili, Tatiana Eliava, Tamar Kalandarishvili, Teimuraz Katamadze   +9 more
doaj   +1 more source

Isolation and Characterization of Six Vibrio parahaemolyticus Lytic Bacteriophages From Seafood Samples

Frontiers in Microbiology, 2021
Vibrio parahaemolyticus is a foodborne pathogen that is frequently isolated from a variety of seafood. To control this pathogenic Vibrio spp., the implementation of bacteriophages in aquaculture and food industries have shown a promising alternative to ...
Chia Wanq Tan, Yaya Rukayadi, Hanan Hasan, Noor-Azira Abdul-Mutalib, Noor-Azira Abdul-Mutalib, Nuzul Noorahya Jambari, Nuzul Noorahya Jambari, Hirofumi Hara, Tze Young Thung, Epeng Lee, Son Radu, Son Radu   +11 more
doaj   +1 more source

Application of bacteriophages [PDF]

Microbiology Australia, 2017
The emergence of antibiotic-resistant bacteria and decrease in the discovery rate of novel antibiotics takes mankind back to the ‘pre-antibiotic era’ and search for alternative treatments. Bacteriophages have been one of promising alternative agents which can be utilised for medicinal and biological control purposes in agriculture and related fields ...
Aminov, Rustam, Caplin, Jonathan, Chanishvili, Nina, Coffey, Aidan, Cooper, Ian, De Vos, Daniel, Doskar, Jiri, Friman, Ville-Petri, Kurtboke, Ipek, Pantucek, Roman, Pirnay, Jean-Paul, Resch, Gregory, Rohde, Christine, Sybesma, Wilbert, Wittmann, Johannes   +14 more
openaire   +4 more sources

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

The Potential of Phage Therapy in Sepsis

Frontiers in Immunology, 2017
Sepsis remains a difficult clinical challenge, since our understanding of its immunopathology is incomplete and no efficacious treatment currently exists. Its earlier stage results from an uncontrolled inflammatory response to bacteria while in the later
Andrzej Górski, Andrzej Górski, Ewa Jończyk-Matysiak, Marzanna Łusiak-Szelachowska, Ryszard Międzybrodzki, Ryszard Międzybrodzki, Beata Weber-Dąbrowska, Jan Borysowski   +7 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source