Results 11 to 20 of about 1,383,161 (168)
Membrane-Sculpting BAR Domains Generate Stable Lipid Microdomains
Cell Reports, 2013 Bin-Amphiphysin-Rvs (BAR) domain proteins are central regulators of many cellular processes involving membrane dynamics. BAR domains sculpt phosphoinositide-rich membranes to generate membrane protrusions or invaginations.
Hongxia Zhao +6 more
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BAR Domain Scaffolds in Dynamin-Mediated Membrane Fission [PDF]
Cell, 2014 Biological membranes undergo constant remodeling by membrane fission and fusion to change their shape and to exchange material between subcellular compartments. During clathrin-mediated endocytosis, the dynamic assembly and disassembly of protein scaffolds comprising members of the bin-amphiphysin-rvs (BAR) domain protein superfamily constrain the ...
Daumke, Oliver +2 more
openaire +5 more sources
Structural Basis of Membrane Invagination by F-BAR Domains [PDF]
Cell, 2008 BAR superfamily domains shape membranes through poorly understood mechanisms. We solved structures of F-BAR modules bound to flat and curved bilayers using electron (cryo)microscopy. We show that membrane tubules form when F-BARs polymerize into helical coats that are held together by lateral and tip-to-tip interactions. On gel-state membranes or after
Frost, Adam +7 more
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Membrane Charge Directs the Outcome of F-BAR Domain Lipid Binding and Autoregulation [PDF]
Cell Reports, 2015 F-BAR domain proteins regulate and sense membrane curvature by interacting with negatively charged phospholipids and assembling into higher-order scaffolds. However, regulatory mechanisms controlling these interactions are poorly understood.
Charlotte F. Kelley +12 more
doaj +2 more sources
LdFlabarin, a new BAR domain membrane protein of Leishmania flagellum. [PDF]
PLoS ONE, 2013 During the Leishmania life cycle, the flagellum undergoes successive assembly and disassembly of hundreds of proteins. Understanding these processes necessitates the study of individual components.
Michèle Lefebvre +10 more
doaj +2 more sources
Protein Folding Mechanism of the Dimeric AmphiphysinII/Bin1 N-BAR Domain. [PDF]
PLoS ONE, 2015 The human AmphyphisinII/Bin1 N-BAR domain belongs to the BAR domain superfamily, whose members sense and generate membrane curvatures. The N-BAR domain is a 57 kDa homodimeric protein comprising a six helix bundle.
Tobias Gruber, Jochen Balbach
doaj +2 more sources
Tetraspanner-based nanodomains modulate BAR domain-induced membrane curvature. [PDF]
EMBO Rep, 2023 Abstract The topography of biological membranes is critical for formation of protein and lipid microdomains. One prominent example in the yeast plasma membrane (PM) are BAR domain‐induced PM furrows. Here we report a novel function for the Sur7 family of tetraspanner proteins in the regulation of local PM topography.
Haase D +13 more
europepmc +3 more sources
An atypical BAR domain protein in autophagy. [PDF]
Autophagy, 2018 The sorting nexin Atg20 interacts with the selective macroautophagy/autophagy scaffolding protein Atg11, suggesting an important role for Atg20 in the initiation of selective autophagy. To explore this possibility, we recently investigated the structure and function of Atg20 using a variety of biophysical and yeast genetic approaches.
Popelka H, Klionsky DJ, Ragusa MJ.
europepmc +4 more sources
Frontiers in Molecular Biosciences, 2021 PICK1 is a multi-domain scaffolding protein that is uniquely comprised of both a PDZ domain and a BAR domain. While previous experiments have shown that the PDZ domain and the linker positively regulate the BAR domain and the C-terminus negatively ...
Amy O. Stevens, Yi He
doaj +1 more source
D-bar Operators on Quantum Domains [PDF]
Mathematical Physics, Analysis and Geometry, 2010 We study the index problem for the d-bar operators subject to Atiyah- Patodi-Singer boundary conditions on noncommutative disk and annulus.
Klimek, Slawomir, McBride, Matt
openaire +2 more sources