Results 11 to 20 of about 1,246,132 (248)
Membrane-Sculpting BAR Domains Generate Stable Lipid Microdomains
Cell Reports, 2013 Bin-Amphiphysin-Rvs (BAR) domain proteins are central regulators of many cellular processes involving membrane dynamics. BAR domains sculpt phosphoinositide-rich membranes to generate membrane protrusions or invaginations.
Hongxia Zhao +6 more
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Membrane Charge Directs the Outcome of F-BAR Domain Lipid Binding and Autoregulation [PDF]
Cell Reports, 2015 F-BAR domain proteins regulate and sense membrane curvature by interacting with negatively charged phospholipids and assembling into higher-order scaffolds. However, regulatory mechanisms controlling these interactions are poorly understood.
Charlotte F. Kelley +12 more
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LdFlabarin, a new BAR domain membrane protein of Leishmania flagellum. [PDF]
PLoS ONE, 2013 During the Leishmania life cycle, the flagellum undergoes successive assembly and disassembly of hundreds of proteins. Understanding these processes necessitates the study of individual components.
Michèle Lefebvre +10 more
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Protein Folding Mechanism of the Dimeric AmphiphysinII/Bin1 N-BAR Domain. [PDF]
PLoS ONE, 2015 The human AmphyphisinII/Bin1 N-BAR domain belongs to the BAR domain superfamily, whose members sense and generate membrane curvatures. The N-BAR domain is a 57 kDa homodimeric protein comprising a six helix bundle.
Tobias Gruber, Jochen Balbach
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Tetraspanner-based nanodomains modulate BAR domain-induced membrane curvature. [PDF]
EMBO Rep, 2023 Abstract The topography of biological membranes is critical for formation of protein and lipid microdomains. One prominent example in the yeast plasma membrane (PM) are BAR domain‐induced PM furrows. Here we report a novel function for the Sur7 family of tetraspanner proteins in the regulation of local PM topography.
Haase D +13 more
europepmc +3 more sources
An atypical BAR domain protein in autophagy. [PDF]
Autophagy, 2018 The sorting nexin Atg20 interacts with the selective macroautophagy/autophagy scaffolding protein Atg11, suggesting an important role for Atg20 in the initiation of selective autophagy. To explore this possibility, we recently investigated the structure and function of Atg20 using a variety of biophysical and yeast genetic approaches.
Popelka H, Klionsky DJ, Ragusa MJ.
europepmc +4 more sources
Frontiers in Molecular Biosciences, 2021 PICK1 is a multi-domain scaffolding protein that is uniquely comprised of both a PDZ domain and a BAR domain. While previous experiments have shown that the PDZ domain and the linker positively regulate the BAR domain and the C-terminus negatively ...
Amy O. Stevens, Yi He
doaj +1 more source
D-bar Operators on Quantum Domains [PDF]
Mathematical Physics, Analysis and Geometry, 2010 We study the index problem for the d-bar operators subject to Atiyah- Patodi-Singer boundary conditions on noncommutative disk and annulus.
Klimek, Slawomir, McBride, Matt
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Disease Models & Mechanisms, 2020 Skeletal muscle development and regeneration are tightly regulated processes. How the intracellular organization of muscle fibers is achieved during these steps is unclear. Here, we focus on the cellular and physiological roles of amphiphysin 2 (BIN1), a
Ivana Prokic +18 more
doaj +1 more source
Communicative & Integrative Biology, 2010 The F-BAR domain is emerging as an important player in membrane remodeling pathways. F-BAR domain proteins couple membrane remodeling with actin dynamics associated with endocytic pathways and filopodium formation. Here, we provide a comprehensive analysis of F-BAR domain proteins in terms of their evolutionary relationships and protein function. F-BAR
Sohail, Ahmed +4 more
openaire +2 more sources