Results 11 to 20 of about 3,184,320 (288)
The Role of BAR Domain Proteins in the Regulation of Membrane Dynamics [PDF]
Acta Naturae, 2016 Many cellular processes are associated with membrane remodeling. The BAR domain protein family plays a key role in the formation and detection of local membrane curvatures and in attracting other proteins, including the regulators of actin dynamics. Based on their structural and phylogenetic properties, BAR domains are divided into several groups which
Tatiana Stanishneva-Konovalova +2 more
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Salt Bridge Formation between the I-BAR Domain and Lipids Increases Lipid Density and Membrane Curvature [PDF]
Scientific Reports, 2017 The BAR domain superfamily proteins sense or induce curvature in membranes. The inverse-BAR domain (I-BAR) is a BAR domain that forms a straight “zeppelin-shaped” dimer.
Kazuhiro Takemura +3 more
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Membrane Charge Directs the Outcome of F-BAR Domain Lipid Binding and Autoregulation [PDF]
Cell Reports, 2015 F-BAR domain proteins regulate and sense membrane curvature by interacting with negatively charged phospholipids and assembling into higher-order scaffolds. However, regulatory mechanisms controlling these interactions are poorly understood.
Charlotte F. Kelley +12 more
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LdFlabarin, a new BAR domain membrane protein of Leishmania flagellum. [PDF]
PLoS ONE, 2013 During the Leishmania life cycle, the flagellum undergoes successive assembly and disassembly of hundreds of proteins. Understanding these processes necessitates the study of individual components.
Michèle Lefebvre +10 more
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Protein Folding Mechanism of the Dimeric AmphiphysinII/Bin1 N-BAR Domain. [PDF]
PLoS ONE, 2015 The human AmphyphisinII/Bin1 N-BAR domain belongs to the BAR domain superfamily, whose members sense and generate membrane curvatures. The N-BAR domain is a 57 kDa homodimeric protein comprising a six helix bundle.
Tobias Gruber, Jochen Balbach
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An atypical BAR domain protein in autophagy. [PDF]
Autophagy, 2018 The sorting nexin Atg20 interacts with the selective macroautophagy/autophagy scaffolding protein Atg11, suggesting an important role for Atg20 in the initiation of selective autophagy. To explore this possibility, we recently investigated the structure and function of Atg20 using a variety of biophysical and yeast genetic approaches.
Popelka H, Klionsky DJ, Ragusa MJ.
europepmc +4 more sources
BAR Domain Proteins—A Linkage Between Cellular Membranes, Signaling Pathways, and the Actin Cytoskeleton [PDF]
Biophysical Reviews, 2018 Peter J Carman, Roberto Dominguez
exaly +2 more sources
Frontiers in Molecular Biosciences, 2021 PICK1 is a multi-domain scaffolding protein that is uniquely comprised of both a PDZ domain and a BAR domain. While previous experiments have shown that the PDZ domain and the linker positively regulate the BAR domain and the C-terminus negatively ...
Amy O. Stevens, Yi He
doaj +1 more source
Disease Models & Mechanisms, 2020 Skeletal muscle development and regeneration are tightly regulated processes. How the intracellular organization of muscle fibers is achieved during these steps is unclear. Here, we focus on the cellular and physiological roles of amphiphysin 2 (BIN1), a
Ivana Prokic +18 more
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D-bar Operators on Quantum Domains [PDF]
Mathematical Physics, Analysis and Geometry, 2010 We study the index problem for the d-bar operators subject to Atiyah- Patodi-Singer boundary conditions on noncommutative disk and annulus.
Klimek, Slawomir, McBride, Matt
openaire +2 more sources