Results 51 to 60 of about 1,246,132 (248)
Revisiting I-BAR Proteins at Central Synapses
Frontiers in Neural Circuits, 2021 Dendritic spines, the distinctive postsynaptic feature of central nervous system (CNS) excitatory synapses, have been studied extensively as electrical and chemical compartments, as well as scaffolds for receptor cycling and positioning of signaling ...
Christina Chatzi, Gary L. Westbrook
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Unraveling N-BAR Domain Initiated Membrane Remodeling [PDF]
Biophysical Journal, 2011 “Reticular” or network-like membrane structures are characteristic of the Golgi and the T-tubule network of skeletal and cardiac muscle, and in the latter case are known in fruit flies to require amphiphysin-2, a member of the N-BAR domain superfamily.
Lyman, Edward R. +2 more
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Membrane sculpting by curved DNA origami scaffolds
Nature Communications, 2018 BAR domain proteins feature a “banana-like” shape which is thought to aid membrane scaffolding and membrane tubulation. Here authors use DNA origami mimicking BAR domains, giant unilamellar vesicles and fluorescence imaging to study how different BAR ...
Henri G. Franquelim +4 more
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The cryo-EM structure of the SNX–BAR Mvp1 tetramer
Nature Communications, 2020 SNX-BAR proteins are a family of PX and BAR domain-containing proteins with pivotal roles in trafficking processes. Here authors present the cryo-EM structure of the full-length fungal SNX-BAR Mvp1, which is an autoinhibited tetramer and provides ...
Dapeng Sun +5 more
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Determination of the HQET Parameters from the $B \to X_s\gamma$ Decay
, 1996 We combine the resummations for radiative corrections and for the heavy quark expansion to study the inclusive radiative decay $B \to X_s\gamma$. The infrared renormalon ambiguity is also taken into account.
A. Ali +18 more
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A PX-BAR protein Mvp1/SNX8 and a dynamin-like GTPase Vps1 drive endosomal recycling
eLife, 2021 Membrane protein recycling systems are essential for maintenance of the endosome-lysosome system. In yeast, retromer and Snx4 coat complexes are recruited to the endosomal surface, where they recognize cargos. They sort cargo and deform the membrane into
Sho W Suzuki +5 more
doaj +1 more source
, 2019 We use lattice QCD to investigate the spectrum of the $\bar{b} \bar{b} u d$ four-quark system with quantum numbers $I(J^P) = 0(1^+)$. We use five different gauge-link ensembles with $2+1$ flavors of domain-wall fermions, including one at the physical ...
Leskovec, Luka +3 more
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F-BAR/EFC Domain Proteins: Some Assembly Required [PDF]
Developmental Cell, 2015 Polymeric spirals of crescent-shaped BAR-domain superfamily proteins are touted to girdle eukaryotic phospholipid bilayers into narrow tubules for trafficking and membrane remodeling events. But McDonald et al. (2015) in this issue of Developmental Cell question whether this broadly held view and conceptually appealing mechanism for membrane sculpting ...
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Mechanism of endophilin N‐BAR domain‐mediated membrane curvature [PDF]
The EMBO Journal, 2006 Endophilin-A1 is a BAR domain-containing protein enriched at synapses and is implicated in synaptic vesicle endocytosis. It binds to dynamin and synaptojanin via a C-terminal SH3 domain. We examine the mechanism by which the BAR domain and an N-terminal amphipathic helix, which folds upon membrane binding, work as a functional unit (the N-BAR domain ...
Jennifer L, Gallop +6 more
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Structural Basis of Membrane Invagination by F-BAR Domains [PDF]
Cell, 2008 BAR superfamily domains shape membranes through poorly understood mechanisms. We solved structures of F-BAR modules bound to flat and curved bilayers using electron (cryo)microscopy. We show that membrane tubules form when F-BARs polymerize into helical coats that are held together by lateral and tip-to-tip interactions. On gel-state membranes or after
Frost, Adam +7 more
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