Results 1 to 10 of about 34,815 (271)

Sodium Amytal – No Longer Prescribed, but Still Relevant (And Dangerous!) [PDF]

BJPsych Open
Aims: Sodium amytal is a barbiturate medication, first synthesised in Germany in the 1920s to treat anxiety and sleep disorders; as well as being used as an anaesthetic.
Conor Brown
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Anti-Inflammatory Effects of the Novel Barbiturate Derivative MHY2699 in an MPTP-Induced Mouse Model of Parkinson’s Disease

Antioxidants, 2021
Parkinson’s disease (PD) is one of the most common neurodegenerative disorders, and is caused by the death of dopamine neurons and neuroinflammation in the striatum and substantia nigra.
Seulah Lee, Yeon Ji Suh, Yujeong Lee, Seonguk Yang, Dong Geun Hong, Dinakaran Thirumalai, Seung-Cheol Chang, Ki Wung Chung, Young-Suk Jung, Hyung Ryong Moon, Hae Young Chung, Jaewon Lee   +11 more
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Cocrystal of Codeine and Cyclopentobarbital

Molbank, 2023
The two-component compound formed by codeine and cyclopentobarbital was produced using grinding techniques and through evaporation from alcoholic solutions.
Thomas Gelbrich, Jascha Schinke, Ulrich J. Griesser   +2 more
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A novel step‐down infusion method of barbiturate therapy: Its safety and effectiveness for intracranial pressure control

Pharmacology Research & Perspectives, 2021
Intracranial pressure (ICP) has to be maintained quite constant, because increased ICP caused by cerebrovascular disease and head trauma is fatal. Although controlling ICP is clinically critical, only few therapeutic methods are currently available ...
Yukako Yamakawa, Motohiro Morioka, Tetsuya Negoto, Kimihiko Orito, Munetake Yoshitomi, Yukihiko Nakamura, Nobuyuki Takeshige, Masafumi Yamamoto, Yasuharu Takeuchi, Kazutaka Oda, Hirofumi Jono, Hideyuki Saito   +11 more
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Combination of antiseizure medications phenobarbital, ketamine, and midazolam reduces soman‐induced epileptogenesis and brain pathology in rats

Epilepsia Open, 2021
Objective Cholinergic‐induced status epilepticus (SE) is associated with a loss of synaptic gamma‐aminobutyric acid A receptors (GABAAR) and an increase in N‐methyl‐D‐aspartate receptors (NMDAR) and amino‐3‐hydroxy‐5‐methyl‐4‐isoxazolepropionic acid ...
Lucille A. Lumley, Brenda Marrero‐Rosado, Franco Rossetti, Caroline R. Schultz, Michael F. Stone, Jerome Niquet, Claude G. Wasterlain   +6 more
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Survival after pentobarbitone overdose confirmed through Prescription, Recreational and Illicit Substance Evaluation (PRISE) programme in Australia

Forensic Sciences Research, 2021
Deaths caused by barbiturate overdoses have increased in the past decade, especially as a result of suicide attempts. Pentobarbitone is a central nervous system depressant used for sedation and euthanasia in veterinary medicine.
Thanjira Jiranantakan, Sarah Ritchie, Cristy Rowe, Jason Tran, Catherine McDonald, Santiago Vazquez, Robin Auld, Jared Brown   +7 more
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Supramolecular Assemblies of Melamine-2-Thiobarbiturate and Melamine-Barbiturate-2-Thiobarbiturate: Experimental and Theoretical Studies

Crystals, 2023
In this work, we considered the formation of supramolecular assemblies of melamine-thiobarbiturate and melamine-barbiturate-thiobarbiturate. It is known that thiobarbituric acid can form many tautomers, as well as different motifs due to the change of C2=
Ivan V. Moskalenko, Vladimir V. Shilovskikh, Pavel V. Nesterov, Alexander S. Novikov, Malika Omarova, Roman V. Sadovnichii, Vladislav V. Gurzhiy, Nikita D. Orekhov, Ekaterina V. Skorb   +8 more
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Crystal structure of 4-aminopyridinium 5-(5-chloro-2,4-dinitrophenyl)-1,3-dimethyl-2,6-dioxo-1,2,3,6-tetrahydropyrimidin-4-olate hemihydrate

Acta Crystallographica Section E, 2014
The title molecular salt, C5H7N2+·C12H8ClN4O7−·0.5H2O, crystallizes as a hemihydrate. The two rings in the barbiturate anion are not coplanar but make a dihedral angle of 43.17 (16)°. The two nitro groups deviate from the ring to which they are attached;
Manickkam Vaduganathan, Kalaivani Doraisamyraja   +1 more
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Unexpected epileptogenic effect of lethal doses of pentobarbital: a case report [PDF]

Journal of Neurocritical Care, 2023
Background Barbiturate poisoning is rare but potentially fatal. Case Report We reported a case of barbiturate poisoning in a 28-year-old woman who recovered from lethal pentobarbital deliberate self-poisoning.
Amélie Giudicelli-Bailly, Chiara Della Badia, Marc Augsburger, Hervé Quintard, Raphaël Giraud, Pia De Stefano   +5 more
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Butallylonal 1,4-dioxane hemisolvate

Acta Crystallographica Section E, 2010
The asymmetric unit of the title compound [systematic name: 5-(1-bromoprop-2-en-1-yl)-5-sec-butylpyrimidine-2,4,6-trione 1,4-dioxane hemisolvate], C11H15BrN2O3·0.5C4H8O2, contains one half-molecule of 1,4-dioxane and one molecule of butallylonal,
Ulrich J. Griesser, Denise Rossi, Thomas Gelbrich   +2 more
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