Results 11 to 20 of about 32,024 (272)
Butallylonal 1,4-dioxane hemisolvate [PDF]
Acta Crystallographica Section E, 2010 The asymmetric unit of the title compound [systematic name: 5-(1-bromoprop-2-en-1-yl)-5-sec-butylpyrimidine-2,4,6-trione 1,4-dioxane hemisolvate], C11H15BrN2O3·0.5C4H8O2, contains one half-molecule of 1,4-dioxane and one molecule of butallylonal,
Ulrich J. Griesser +2 more
doaj +5 more sources
N,N-Diethylanilinium 2,4-dioxo-5-(2,4,6-trinitrophenyl)-1,2,3,4-tetrahydropyrimidin-6-olate [PDF]
Acta Crystallographica Section E, 2011 In the crystal structure of the title molecular salt, C10H16N+·C10H4N5O9−, the components are linked through a N—H...O hydrogen bonds. R22(8) ring motifs are formed between inversion-related barbiturate residues.
Manickam Buvaneswari +1 more
doaj +4 more sources
N,N-Diethyl-2-hydroxyethanaminium 2,6-dioxo-5-(2,4,6-trinitrophenyl)-1,2,3,6-tetrahydropyrimidin-4-olate dihydrate [PDF]
Acta Crystallographica Section E, 2011 In the title molecular salt, C6H16NO+·C10H4N5O9−·2H2O, which crystallizes as a dihydrate, O—H...O hydrogen bonds link the barbiturate anion, the ethanaminium cation and the water molecules of crystallization.
Manickam Buvaneswari +1 more
doaj +4 more sources
Trimethylammonium 2,6-dioxo-5-(2,4,6-trinitrophenyl)-1,2,3,6-tetrahydropyrimidin-4-olate [PDF]
Acta Crystallographica Section E, 2012 In the title barbiturate salt (trivial name: trimethylammonium 2,4,6-trinitrophenylbarbiturate), C3H10N+·C10H4N5O9−, the asymmetric unit contains two sets of anion–cation moieties.
D. Kalaivani +2 more
doaj +3 more sources
The thermodynamics of general and local anesthesia [PDF]
Biophys. J. 2014, 106: 2143-2156, 2014 General anesthetics are known to cause depression of the freezing point of transitions in biomembranes. This is a consequence of ideal mixing of the anesthetic drugs in the membrane fluid phase and exclusion from the solid phase. Such a generic law provides physical justification of the famous Meyer-Overton rule.
Graesboll, Kaare +2 more
arxiv +4 more sources
Epilepsia Open, EarlyView., 2023 Abstract Growing concerns over rigor and reproducibility of preclinical studies, including consistency across laboratories and translation to clinical populations, have triggered efforts to harmonize methodologies. This includes the first set of preclinical common data elements (CDEs) for epilepsy research studies, as well as Case Report Forms (CRFs ...
Lisa Coles +9 more
wiley +1 more source
Neuropsychopharmacology Reports, Volume 42, Issue 4, Page 421-429, December 2022., 2022 Abstract Background Depression is a common disorder that affects patients' quality of life and incurs health system costs. Due to the resistance to treat depression, better understanding of neurophysiology was considered; one of the implications is the glutamatergic system.
Ahmad Shamabadi
wiley +1 more source
Population pharmacokinetic modeling of daridorexant, a novel dual orexin receptor antagonist
CPT: Pharmacometrics &Systems Pharmacology, Volume 12, Issue 1, Page 74-86, January 2023., 2023 Abstract The analysis aimed at identifying subject‐specific characteristics (covariates) influencing exposure to daridorexant and quantification of covariate effects to determine clinical relevance. Data from 13 phase I, two phase II, and two phase III studies were pooled to develop a population pharmacokinetic model describing daridorexant ...
Andreas Krause +4 more
wiley +1 more source
Journal of Diabetes, Volume 15, Issue 1, Page 7-14, January 2023., 2023 Highlights Red blood cell (RBC) lifespan variation, is the main cause of variation in glycosylated hemoglobin (HbA1c), independent of blood glucose levels. This study highlighted the important impact of RBC lifespan on HbA1c test value in T2DM with HbA1c test value <7%. We discovered that the HbA1c test value in type 2 diabetes (T2DM) patients with RBC
Junmei Wang +6 more
wiley +1 more source
Narcotics Addiction and Its Treatment [PDF]
, 1957 The ongoing mythologizing of the poet in both criticism and, as recently in a play produced by Wasa teater (Vasa), is reductive, and needs to be confronted.
Winick, Charles
core +4 more sources