Results 21 to 30 of about 13,750 (173)
Barbiturate AEDS, EEG and Cognitive Performance
Pediatric Neurology Briefs, 1997 Neuropsychological performance and quantitative EEGs were studied in 11 epileptic children, aged 7 to 14 years, both during treatment and without phenobarbital and mephobarbital, and in comparison to 13 matched controls, at Tulane University Medical ...
J Gordon Millichap
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Therapeutic profile of antiepileptics in patients from the Wilaya of Batna. A retrospective study on 106 cases. [PDF]
Batna Journal of Medical SciencesIntroduction. Therapeutic monitoring of conventional antiepileptic drugs is an essential approach to optimize the management of epileptic patients.
Soumaya BOUDJEMAA +9 more
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Barbiturate-refractory epilepsy: safe schedule for therapeutic substitution
Arquivos de Neuro-Psiquiatria, 1986 Barbiturates are considered first line antiepileptic drugs in third world countries due to traditional and economic reasons. This prospective uncontrolled study of 52 patients aged 15 to 64 years (mean 24) demonstrates that patients who become refractory
Ana Maria Gorz +2 more
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Enamine Barbiturates and Thiobarbiturates as a New Class of Bacterial Urease Inhibitors
Applied Sciences, 2020 Urease is a therapeutic target associated with several important diseases and health problems. Based on our previous work on the inhibition of glucosidase and other enzymes and exploiting the privileged structure assigned to the (thio)barbiturate ...
M. Ali +9 more
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ChemElectroChem, 2023 A highly efficient, fast, catalyst‐free, and atom economical method was developed for the synthesis of 5‐benzylidenebarbiturates. Thus, reacting barbituric acid and aldehydes in water as a green solvent under electrochemical conditions afforded the ...
Dr. Yara S. El‐Dash +3 more
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Advanced Materials, EarlyView.A novel FIRINOX‐loaded implant demonstrates controlled drug release, and potent therapeutic efficacy in pancreatic ductal adenocarcinoma mouse models with safety confirmed in a large‐animal pre‐clinical model. This innovative drug delivery platform offers a promising new treatment approach for non‐resectable, treatment‐resistant pancreatic cancer ...
Samantha J. Wade +19 more
wiley +1 more source
N,N-Diethylanilinium 2,4-dioxo-5-(2,4,6-trinitrophenyl)-1,2,3,4-tetrahydropyrimidin-6-olate
Acta Crystallographica Section E, 2011 In the crystal structure of the title molecular salt, C10H16N+·C10H4N5O9−, the components are linked through a N—H...O hydrogen bonds. R22(8) ring motifs are formed between inversion-related barbiturate residues.
Manickam Buvaneswari +1 more
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Sleep disorders related to index and comorbid mental disorders and psychotropic drugs
Annals of General Psychiatry, 2023 Purpose Mental disorders positively associate with sleep disorders. This study will explore the moderating influence of comorbid mental disorders and whether selected psychotropic drugs correlate with sleep disorders after adjusting for mental disorders.
Ray M. Merrill +2 more
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Zuranolone: A case study in (regulatory) rush to judgement?
British Journal of Clinical Pharmacology, EarlyView.Abstract Sage, in collaboration with Biogen, submitted a new drug approval for zuranolone for postpartum depression (PPD) and major depressive disorder (MDD) in December 2022. In August 2023, the US Food and Drug Administration granted approval for PPD but denied approval for MDD.
Lisa Cosgrove +4 more
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5,5-Dihydroxybarbituric acid 1,4-dioxane hemisolvate
Acta Crystallographica Section E, 2010 The asymmetric unit of the title compound,, C4H4N2O5·0.5C4H8O2, contains one molecule of 5,5-dihydroxybarbituric acid with a nearly planar barbiturate ring and half a molecule of 1,4-dioxane.
Thomas Gelbrich +2 more
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