Results 31 to 40 of about 34,333 (275)

Voltage imaging of waking mouse cortex reveals emergence of critical neuronal dynamics. [PDF]

, 2014
Complex cognitive processes require neuronal activity to be coordinated across multiple scales, ranging from local microcircuits to cortex-wide networks.
Fagerholm, ED, Knöpfel, T, Leech, R, Mutoh, H, Scott, G, Sharp, DJ, Shew, WL   +6 more
core   +2 more sources

Efficacy and safety of a selective partial agonist for nociception/orphanin‐FQ peptide (NOP) receptors in patients with insomnia disorder

British Journal of Clinical Pharmacology, EarlyView.
Aims Insomnia is a common sleep disorder, affecting up to 20% of the world population and adversely impacting productivity, health, and overall well‐being. Although pharmacologic options exist to treat insomnia, the health‐related quality of life for patients who are prescribed hypnotics is no higher than for those who are not, revealing a significant ...
Garth T. Whiteside, Ellie He, S. Shet Manjunath, Mingyan Zhou, Maha Ahmad, Stephen C. Harris   +5 more
wiley   +1 more source

N,N-Diethyl-2-hydroxyethanaminium 2,6-dioxo-5-(2,4,6-trinitrophenyl)-1,2,3,6-tetrahydropyrimidin-4-olate dihydrate

Acta Crystallographica Section E, 2011
In the title molecular salt, C6H16NO+·C10H4N5O9−·2H2O, which crystallizes as a dihydrate, O—H...O hydrogen bonds link the barbiturate anion, the ethanaminium cation and the water molecules of crystallization.
Manickam Buvaneswari, Doraisamyraja Kalaivani   +1 more
doaj   +1 more source

Too Sick to Be Executed: Shocking Punishment and the Brain [PDF]

, 2016
Capital punishment, to be lawfully delivered, must occur without needless cruelty. Cruelty, defined in the setting of punishment, will naturally evolve with the maturation of civil society.
Zivot, Joel
core   +1 more source

Neuroactive steroids in depression and anxiety disorders: Clinical studies [PDF]

, 2006
Certain neuroactive steroids modulate ligand-gated ion channels via non-genomic mechanisms. Especially 3 alpha-reduced pregnane steroids are potent positive allosteric modulators of the gamma-aminobutyric acid type A (GABA(A)) receptor.
Akwa Y, Baghai TC, Baker ER, Barrett-Connor E, Bicikova M, Bitran D, Bloch M, Brambilla F, Brambilla F, Brambilla F, Cornelius Schüle, Crawley JN, Dalton K, Daniela Eser, Dennerstein L, Dong E, Elena Romeo, Eser D, Evans RM, Fabian TJ, Freeman E, Freeman EW, Friess E, George MS, Goodyer IM, Guidotti A, Heydari B, Heydary B, Kita A, Koszycki D, Lawrie TA, Maayan R, Magill PJ, Majewska MD, Majewska MD, Majewska MD, Matsumoto K, Meieran SE, Melchior CL, Melchior CL, Mensah-Nyagan AG, Mienville JM, Monnet FP, Padberg F, Papadopoulos V, Paul SM, Purdy RH, Rainer Rupprecht, Reddy DS, Reddy DS, Reddy DS, Rodgers RJ, Romeo E, Rupprecht R, Rupprecht R, Schmidt PJ, Schule C, Schule C, Semeniuk T, Serra M, Serra M, Strohle A, Strohle A, Strohle A, Strous RD, Takebayashi M, Thomas C. Baghai, Tollefson GD, Trauger JW, Urani A, Uzunov DP, Uzunova V, Uzunova V, Uzunova V, Vanselow W, Wieland S, Wolkowitz OM, Wolkowitz OM, Wu FS, Zwanzger P   +79 more
core   +1 more source

Phenobarbital Bioequivalence in Chinese Population: Considering the Role of Food on Pharmacokinetics

Clinical Pharmacology in Drug Development, EarlyView.
Abstract Epilepsy is one of the most severe neurological disorders in the world, which might seriously endanger the lives of patients. Phenobarbital is an important medicine clinically used for the treatment of epilepsy, and it is irreplaceable in the treatment of generalized tonic–clonic seizures, focal seizures, status epilepticus, and pediatric ...
Wang Xinman, Liu Yuan, Sun Ying, Wang Yiyun   +3 more
wiley   +1 more source

Trimethylammonium 2,6-dioxo-5-(2,4,6-trinitrophenyl)-1,2,3,6-tetrahydropyrimidin-4-olate

Acta Crystallographica Section E, 2012
In the title barbiturate salt (trivial name: trimethylammonium 2,4,6-trinitrophenylbarbiturate), C3H10N+·C10H4N5O9−, the asymmetric unit contains two sets of anion–cation moieties.
D. Kalaivani, M. Buvaneswari, S. Rajeswari   +2 more
doaj   +1 more source

Infant Death due to Cannabis Ingestion

Drug Testing and Analysis, EarlyView.
ABSTRACT A child died in the emergency room of a local hospital a few hours after ingesting a substance the color of cork and the consistency of earth. At home, a modest amount of resinous substance was found. At the hospital, the child exhibited alterations in walking, balance, and consciousness.
Donata Favretto, Antonello Cirnelli, Roberto Pertile, Raffaella Stimamiglio, Clara Cestonaro, Oriana Cuman, Anna Pagliaro, Fabio Mattiazzi, Cristina Basso, Maddalena Galeazzi   +9 more
wiley   +1 more source

Dynamics of postnatal bone development and epiphyseal synostosis in the caprine autopod

Developmental Dynamics, EarlyView.
Abstract Background Bones develop to structurally balance strength and mobility. Bone developmental dynamics are influenced by whether an animal is ambulatory at birth. Precocial species, which are ambulatory at birth, develop advanced skeletal maturity in utero and experience postnatal development under mechanical loading.
Christopher J. Panebianco, Maha Essaidi, Elijah Barnes, Ashley Williams, Karin Vancíková, Margot C. Labberté, Pieter Brama, Niamh C. Nowlan, Joel D. Boerckel   +8 more
wiley   +1 more source

Seminar in Epileptology: Normal awake and sleep patterns, interictal abnormalities, and ictal patterns on scalp EEG

Epileptic Disorders, EarlyView.
Abstract The accurate interpretation of scalp EEG remains an instrumental diagnostic component of epilepsy care. Knowledge of what constitutes normal EEG findings, non‐epileptiform abnormalities, and epileptiform patterns—both ictal and interictal—is essential for appropriate patient management.
Juan Luis Alcala‐Zermeno, Roohi Katyal, Birgit Frauscher, Donald Schomer, Michael R. Sperling, Roy Strowd, William O. Tatum, Elaine Wirrell, Sándor Beniczky, Fábio A. Nascimento   +9 more
wiley   +1 more source