Results 41 to 50 of about 13,750 (173)
Piezo-Responsive Hydrogen-Bonded Frameworks Based on Vanillin-Barbiturate Conjugates
Molecules, 2022 A concept of piezo-responsive hydrogen-bonded π-π-stacked organic frameworks made from Knoevenagel-condensed vanillin–barbiturate conjugates was proposed.
Anna S. Nebalueva +10 more
doaj +1 more source
Clinical trajectories and medication response in TBC1D24‐related epilepsies
Epilepsia, EarlyView.Abstract Objective Biallelic variants in TBC1D24 represent a rare cause of epilepsy and neurodevelopmental disorders, including severe developmental and epileptic encephalopathies. Here, we present the first attempt to delineate the longitudinal disease histories and effectiveness of antiseizure medications (ASMs) in TBC1D24‐related disorders.
Ealing Mondragon +9 more
wiley +1 more source
Treatment approaches in posthypoxic myoclonus: A narrative review with expert opinion
Epilepsia, EarlyView.Abstract Acute posthypoxic myoclonus (PHM) is a neurological complication that typically emerges within 12–48 h following cardiac arrest, often in comatose patients. It can present as generalized, multifocal, or focal myoclonus and has traditionally been associated with poor prognosis.
Marina Romozzi +7 more
wiley +1 more source
Trimethylammonium 5-(2,4-dinitrophenyl)-2,6-dioxo-1,2,3,6-tetrahydropyrimidin-4-olate 0.125-hydrate
Acta Crystallographica Section E, 2013 The asymmetric unit of the title salt C3H10N+·C10H5N4O7−·0.125H2O [trivial name: trimethylammonium 5-(2,4-dinitrophenyl)barbiturate 0.125-hydrate], contains two independent cations, two independent anions and a 0.25-occupancy solvent ...
Govindan Mangaiyarkarasi +1 more
doaj +1 more source
Headache: The Journal of Head and Face Pain, EarlyView.Abstract Objective The primary objective of this study was to evaluate opioid and barbiturate utilization before and after the first prescription of the calcitonin gene–related peptide receptor antagonist rimegepant in individuals with migraine. Background Although not recommended in migraine treatment guidelines, opioids and barbiturates are often ...
Noah Rosen +6 more
wiley +1 more source
N,N-Diethylanilinium 5-(2,4-dinitrophenyl)-2,6-dioxo-1,2,3,6-tetrahydropyrimidin-4-olate
Acta Crystallographica Section E, 2013 The asymmetric unit of the title molecular salt, C10H16N+·C10H5N4O7− (trivial name: N,N-diethylanilinium 2,4-dinitrophenylbarbiturate), comprises two anion–cation units.
Govindan Mangaiyarkarasi +1 more
doaj +1 more source
Integrating gepants into clinical practice for the acute treatment of migraine
Headache: The Journal of Head and Face Pain, EarlyView.Abstract Objective To assess the role of small‐molecule calcitonin gene–related peptide receptor antagonists (gepants) in the acute treatment of migraine, particularly in relation to triptan treatments. Background Triptans have established efficacy and are widely prescribed for the acute treatment of migraine.
Richard B. Lipton +4 more
wiley +1 more source
Beilstein Journal of Organic Chemistry, 2022 Bifunctional thiourea-catalyzed asymmetric [3 + 2] annulation reactions of 2-isothiocyanato-1-indanones with barbiturate-based olefins have been developed to afford chiral dispiro[indene-pyrrolidine-pyrimidine]s.
Jiang-Song Zhai, Da-Ming Du
doaj +1 more source
Headache: The Journal of Head and Face Pain, EarlyView.Abstract Objective To highlight key factors required to optimize multi‐mechanistic approaches with oral combination treatments for the acute management of a migraine attack. Background Given the complex multi‐factorial nature of migraine, combining treatments with different mechanisms of action should improve outcomes compared to monotherapies, but ...
Stephen Silberstein, Alan M. Rapoport
wiley +1 more source
Drugs analysis using latex agglutination tests
Тонкие химические технологии, 2011 The method of latex agglutination was used to develop express diagnostics of the most extended groups of drugs (opiates, cannabinoides and barbiturates).
N. М. Solodukhina +3 more
doaj