Thalamus not basal forebrain is atrophied in non‐demented PSEN1 E280A carriers [PDF]
Alzheimer’s & Dementia: Diagnosis, Assessment & Disease MonitoringINTRODUCTION A previous study of non‐demented presenilin‐1 (PSEN1) E280A carriers found basal forebrain and hippocampus, but not the thalamus, to be preserved.
Stefan Teipel +6 more
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Adolescent adversity persistently induces proinflammatory HMGB1 signaling and disrupts the basal forebrain cholinergic system in female rats [PDF]
Neurobiology of StressAdolescence is a critical period of neurodevelopment characterized by heightened neuroplasticity and refinement of executive functioning and cognition.
Hayley Ross +8 more
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Association of Alzheimer’s and Lewy body disease pathology with basal forebrain volume and cognitive impairment [PDF]
Alzheimer’s Research & TherapyBackground Degeneration of the basal forebrain cholinergic system is a hallmark feature shared by Alzheimer’s disease (AD) and Lewy body disease (LBD) whereas hippocampus atrophy is more specifically related to AD.
Julia Schumacher +2 more
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Multimodal neuroimaging unveils basal forebrain-limbic system circuit dysregulation in cognitive impairment with depression: a pathway to early diagnosis and intervention [PDF]
The Journal of Prevention of Alzheimer's DiseaseBackground: Alzheimer’s disease (AD) frequently co-occurs with depressive symptoms, exacerbating both cognitive decline and clinical complexity, yet the neural substrates linking this co-occurrence remain poorly understood.
Xiaowen Xu +10 more
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Cholinergic basal forebrain degeneration is associated with central fatigue in Parkinson’s disease [PDF]
Front NeurolLi Li +8 more
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Nitrative stress activates JNK and decreases retrograde transport of brain‐derived neurotrophic factor in basal forebrain cholinergic neurons [PDF]
Alzheimers DementJessica Fisher +3 more
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Adolescent binge ethanol-induced loss of basal forebrain cholinergic neurons and neuroimmune activation are prevented by exercise and indomethacin. [PDF]
PLoS ONE, 2018 Basal forebrain cholinergic neurons mature in adolescence coinciding with development of adult cognitive function. Preclinical studies using the rodent model of adolescent intermittent ethanol (AIE; 5.0 g/kg, i.g., 2-days on/2-days off from postnatal day
Ryan P Vetreno, Fulton T Crews
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Cognitive Deficits in Aging Related to Changes in Basal Forebrain Neuronal Activity
Cells, 2023 Aging is a physiological process accompanied by a decline in cognitive performance. The cholinergic neurons of the basal forebrain provide projections to the cortex that are directly engaged in many cognitive processes in mammals.
Irene Chaves-Coira +4 more
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The basal forebrain contributes to cue-based spatial navigation performance inAlzheimer’s disease
Frontiers in Aging Neuroscience, 2015 The basal forebrain degenerates in Alzheimer’s disease (AD) and this process is believed to contribute to the cognitive decline observed in AD patients.
Georg M Kerbler +13 more
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Brain and Behavior, 2020 Introduction The mechanisms underlying sleep deprivation‐induced memory impairments and relevant compensatory signaling pathways remain elusive. We tested the hypothesis that increased brain‐derived neurotrophic factor (BDNF) expression in the basal ...
Tao Ma +9 more
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