Results 191 to 200 of about 45,649 (267)

Clinical presentation and management of repetitive circling behaviour in a working cocker spaniel secondary to meningoencephalomyelitis of unknown aetiology

open access: yesVeterinary Record Case Reports, Volume 14, Issue 1, February 2026.
Abstract A 3‐year‐old, entire, male cocker spaniel presented for behavioural assessment following a 2.5‐year history of compulsive circling to the right‐hand side. It was previously diagnosed with meningomyelitis of unknown aetiology, following an acute onset of blindness in the left eye and decreased postural reactions.
Emma Gatehouse, Vera Pisco
wiley   +1 more source

Troriluzole attenuates opioid intake, reinforcing efficacy, seeking behaviours, physical dependence and antinociceptive tolerance in rats

open access: yesBritish Journal of Pharmacology, Volume 183, Issue 3, Page 505-519, February 2026.
Background and Purpose Riluzole, approved for amyotrophic lateral sclerosis (ALS), has a glutamate‐modulating profile favourable for mitigating opioid addiction. It reduces neuronal glutamate release and enhances glutamate reuptake, offering advantages over agents that only increase glutamate reuptake.
Ewa Galaj   +7 more
wiley   +1 more source

Relationship of cholinergic basal forebrain atrophy with the time course of Alzheimer's disease pathology and cognitive decline in adults with Down syndrome: a longitudinal cohort study. [PDF]

open access: yesAlzheimers Dement
Russell JK   +7 more
europepmc   +1 more source

Administration of the Sleep‐Promoting Neuromodulator Adenosine Into the Median Preoptic and Septal Region Produced Thermal Hyperalgesia

open access: yesJournal of Sleep Research, Volume 35, Issue 1, February 2026.
ABSTRACT Abundant clinical and preclinical evidence demonstrates that sleep and pain have bidirectional interactions. Sleep loss enhances pain perception and pain disrupts sleep. However, the exact neurobiological mechanisms through which sleep loss alters pain remain poorly understood.
Viviane S. Hambrecht‐Wiedbusch   +5 more
wiley   +1 more source

Single-nucleus analysis reveals oxidative stress in Down syndrome basal forebrain neurons at birth. [PDF]

open access: yesAlzheimers Dement
West NR   +11 more
europepmc   +1 more source

Defining the Intestinal eCBome and Oxylipin Signaling Systems in a TDP‐43 Mouse Model of Frontotemporal Dementia

open access: yesThe FASEB Journal, Volume 40, Issue 2, 31 January 2026.
TDP‐43 overexpressing mice, a genetic model of frontotemporal dementia, exhibit dramatic changes in their small intestinal endocannabinoidome members, in terms of both altered concentrations of lipid mediators and expression of some of their receptors (Cnr1, Gpr119, Gpr55, Pparg) and metabolic enzymes (Napepld, Faah). Also, the levels of some oxylipins
Hayatte‐Dounia Mir   +9 more
wiley   +1 more source

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