Results 21 to 30 of about 45,649 (267)
Basal forebrain atrophy correlates with amyloid β burden in Alzheimer's disease
NeuroImage: Clinical, 2015 The brains of patients suffering from Alzheimer's disease (AD) have three classical pathological hallmarks: amyloid-beta (Aβ) plaques, tau tangles, and neurodegeneration, including that of cholinergic neurons of the basal forebrain.
Georg M Kerbler +6 more
doaj +1 more source
Physiological properties of cholinergic and non-cholinergic magnocellular neurons in acute slices from adult mouse nucleus basalis. [PDF]
PLoS ONE, 2010 BackgroundThe basal forebrain is a series of nuclei that provides cholinergic input to much of the forebrain. The most posterior of these nuclei, nucleus basalis, provides cholinergic drive to neocortex and is involved in arousal and attention.
Tristan Hedrick, Jack Waters
doaj +1 more source
Cell Assemblies of the Basal Forebrain [PDF]
The Journal of Neuroscience, 2015 The basal forebrain comprises several heterogeneous neuronal subgroupings having modular projection patterns to discrete sets of cortical subregions. Each cortical region forms recurrent projections, via prefrontal cortex, that reach the specific basal forebrain subgroups from which they receive afferents.
David Tingley +4 more
openaire +2 more sources
Alzheimer’s Research & Therapy, 2022 Background The degeneration of the cholinergic circuit from the basal forebrain to the hippocampus contributes to memory loss in patients suffering from Alzheimer’s disease (AD).
Weilin Liu +8 more
doaj +1 more source
Sensory perception drives food avoidance through excitatory basal forebrain circuits
eLife, 2019 Appetite is driven by nutritional state, environmental cues, mood, and reward pathways. Environmental cues strongly influence feeding behavior, as they can dramatically induce or diminish the drive to consume food despite homeostatic state. Here, we have
Jay M Patel +8 more
doaj +1 more source
The basal forebrain serves social information processing
Current Opinion in Behavioral Sciences, 2023 Empirical evidence suggests a critical, but little understood, contribution of the basal forebrain (BF) to motivational aspects of social cognition. Therefore, we review the current literature on reward and punishment processing in the BF, including social information, in both animals and more recently human imaging studies.
Alexandra Sobczak, Nico Bunzeck
openaire +1 more source
Lesions of the basal forebrain cholinergic system in mice disrupt idiothetic navigation.
PLoS ONE, 2013 Loss of integrity of the basal forebrain cholinergic neurons is a consistent feature of Alzheimer's disease, and measurement of basal forebrain degeneration by magnetic resonance imaging is emerging as a sensitive diagnostic marker for prodromal disease.
Adam S Hamlin +4 more
doaj +1 more source
Bisphenol-A Neurotoxic Effects on Basal Forebrain Cholinergic Neurons In Vitro and In Vivo
Biology, 2023 The widely used plasticizer bisphenol-A (BPA) is well-known for producing neurodegeneration and cognitive disorders, following acute and long-term exposure.
Andrea Flores +10 more
doaj +1 more source
Frontiers in Neurology, 2018 Background: Predicting the progression of cognitive decline in Alzheimer's disease (AD) is important for treatment selection and patient counseling. Structural MRI markers such as hippocampus or basal forebrain volumes might represent useful instruments ...
Stefan J. Teipel +13 more
doaj +1 more source
Nerve Growth Factor Compromise in Down Syndrome
Frontiers in Aging Neuroscience, 2021 The basal forebrain cholinergic system relies on trophic support by nerve growth factor (NGF) to maintain its phenotype and function. In Alzheimer’s disease (AD), basal forebrain cholinergic neurons (BFCNs) undergo progressive atrophy, suggesting a ...
Sonia Do Carmo +5 more
doaj +1 more source