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Base editing goes into hyperdrive
Nature Cell Biology, 2020CRISPR base editors can induce single-base-pair changes in the genome, although they are often inefficient. A study now shows that fusion of the DNA-binding domain of RAD51 to base editors enhances both the efficiency and the targeting range of optimized enzymes. These ‘hyper-editors’ offer effective tools for disease modeling and gene therapy.
Alyna Katti, Lukas E. Dow
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Pattern Recognition, 2003
In this paper, we demonstrate how to edit digital photos based on the understanding of high-level geometric knowledge imposed upon objects in the photos. This is achieved by the correct recovery of the 3-D shape and relationships of the objects, without explicitly performing full 3-D reconstruction.
Kun Huang 0001 +2 more
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In this paper, we demonstrate how to edit digital photos based on the understanding of high-level geometric knowledge imposed upon objects in the photos. This is achieved by the correct recovery of the 3-D shape and relationships of the objects, without explicitly performing full 3-D reconstruction.
Kun Huang 0001 +2 more
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Cytosine Base Editing in Bacteria
2023Base editing is a new genome editing technology that enables DNA base mutations without requiring double-stranded DNA backbone cleavage or a donor template. It has been widely used for genome engineering of eukaryotic and prokaryotic microorganisms.
Ye, Liu +4 more
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Nature Biotechnology, 2017
Research on base editing leads to new enzymes, genome-wide specificity measurements, and edited plants and animals.
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Research on base editing leads to new enzymes, genome-wide specificity measurements, and edited plants and animals.
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Physically Based Video Editing
Computer Graphics Forum, 2016AbstractConvincing manipulation of objects in live action videos is a difficult and often tedious task. Skilled video editors achieve this with the help of modern professional tools, but complex motions might still lack physical realism since existing tools do not consider the laws of physics.
Jean-Charles Bazin +5 more
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Current knowledge of base editing and prime editing
Molekulârnaâ biologiâModern genetic engineering technologies, such as base editing (BE) and prime editing (PE), have proven to be effective and reliable genome editing tools that do not require the introduction of double-strand breaks in DNA and the presence of donor templates.
O A, Averina +3 more
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Towards therapeutic base editing
Nature Medicine, 2018Base editors function in mouse fetuses and in the livers of adult mice to treat a genetic disorder.
Huiyun Seo, Jin-Soo Kim
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2016
This paper presents an interactive font search method for users who have no significant knowledge of fonts. The proposed method suggests some font candidates by deforming a displayed font image into a font resembling a user's desired font. Generally, font category names, font tags regarding human impressions such as "Cute", and a font list are used for
Ken Ishibashi, Kazunori Miyata
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This paper presents an interactive font search method for users who have no significant knowledge of fonts. The proposed method suggests some font candidates by deforming a displayed font image into a font resembling a user's desired font. Generally, font category names, font tags regarding human impressions such as "Cute", and a font list are used for
Ken Ishibashi, Kazunori Miyata
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Engineering CjCas9 for Efficient Base Editing and Prime Editing
The CRISPR JournalThe CRISPR-Cas9 system has been applied for clinical applications of gene therapy. Most CRISPR-based gene therapies are derived from Streptococcus pyogenes Cas9, which is challenging to package into a single adeno-associated virus vector and limits its clinical applications.
Siyuan Liu +4 more
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