Results 261 to 270 of about 59,740 (306)
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2006
From the simplest to the most complex organism, cells have to perform a myriad of tasks to ensure cellular maintenance, survival, reproduction and even cell death. The orchestration of these tasks is performed by the many cellular proteins coded for in our genetic material, or DNA.
Meira, LB, Burgis, NE, Samson, LD
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From the simplest to the most complex organism, cells have to perform a myriad of tasks to ensure cellular maintenance, survival, reproduction and even cell death. The orchestration of these tasks is performed by the many cellular proteins coded for in our genetic material, or DNA.
Meira, LB, Burgis, NE, Samson, LD
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Mitochondrial Base Excision Repair Assays
2012Mitochondrial DNA (mtDNA) is constantly exposed to oxidative injury. Due to its location close to the main site of reactive oxygen species, the inner mitochondrial membrane, mtDNA is more susceptible than nuclear DNA to oxidative damage. The accumulation of DNA damage is thought to be particularly deleterious in post-mitotic cells, including neurons ...
Gredilla, Ricardo, Stevnsner, Tinna
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The base excision repair pathway
Trends in Biochemical Sciences, 1995The base excision repair pathway has evolved to protect cells from the deleterious effects of endogenous DNA damage induced by hydrolysis, reactive oxygen species and other intracellular metabolites that modify DNA base structure. However, base excision repair is also important to resist lesions produced by ionizing radiation and strong alkylating ...
E, Seeberg, L, Eide, M, Bjørås
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Cellular and Molecular Life Sciences, 2008
DNA repair is a collection of several multienzyme, multistep processes keeping the cellular genome intact against genotoxic insults. One of these processes is base excision repair, which deals with the most ubiquitous lesions in DNA: oxidative base damage, alkylation, deamination, sites of base loss and single-strand breaks, etc.
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DNA repair is a collection of several multienzyme, multistep processes keeping the cellular genome intact against genotoxic insults. One of these processes is base excision repair, which deals with the most ubiquitous lesions in DNA: oxidative base damage, alkylation, deamination, sites of base loss and single-strand breaks, etc.
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Targeting Base Excision Repair for Chemosensitization
Anti-Cancer Agents in Medicinal Chemistry, 2008In both bacteria and eukaryotes the alkylated, oxidized, and deaminated bases and depurinated lesions are primarily repaired via an endogenous preventive pathway, i.e. base excision repair (BER). Radiation therapy and chemotherapy are two important modes of cancer treatment. Many of those therapeutic agents used in the clinic have the ability to induce
Sanjay, Adhikari +5 more
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Base excision repair in nucleosome substrates
Chromosome Research, 2006Eukaryotic cells must repair DNA lesions within the context of chromatin. Much of our current understanding regarding the activity of enzymes involved in DNA repair processes comes from in-vitro studies utilizing naked DNA as a substrate. Here we review current literature investigating how enzymes involved in base excision repair (BER) contend with ...
Indu, Jagannathan +2 more
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Enzymology of mitochondrial base excision repair
2001A number of laboratories have shown that those types of DNA damage that are generally reparable by base excision repair are efficiently repaired in mtDNA. In contrast, most types of damage that require other sorts of repair machinery are not effectively repaired in mtDNA.
D F, Bogenhagen +2 more
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Base excision and nucleotide excision repair pathways in mycobacteria
Tuberculosis, 2011About a third of the human population is estimated to be infected with Mycobacterium tuberculosis. The bacterium displays an excellent adaptability to survive within the host macrophages. As the reactive environment of macrophages is capable of inducing DNA damage, the ability of the pathogen to safeguard its DNA against the damage is of paramount ...
Kurthkoti, Krishna, Varshney, Umesh
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DNA modifications repaired by base excision repair are epigenetic
DNA Repair, 2013CREB controls ∼25% of the mammalian transcriptome. Small changes in binding to its consensus (CRE) sequence are likely to be amplified many fold in initiating transcription. Here we show that DNA lesions repaired by the base excision repair (BER) pathway modulate CREB binding to CRE. We generated Kd values by electrophoretic mobility shift assays using
Stephen P G, Moore +2 more
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