Results 21 to 30 of about 967,825 (378)
Clinical Cancer Research, 2020 Purpose: Emergence of mismatch repair (MMR) deficiency is a frequent mechanism of acquired resistance to the alkylating chemotherapeutic temozolomide (TMZ) in gliomas.
Fumi Higuchi +5 more
semanticscholar +1 more source
The Role of DNA Damage and Repair in Idiopathic Pulmonary Fibrosis
Antioxidants, 2022 The mortality rate of idiopathic pulmonary fibrosis (IPF) increases yearly due to ineffective treatment. Given that the lung is exposed to the external environment, it is likely that oxidative stress, especially the stimulation of DNA, would be of ...
Jiahui Zhu +10 more
doaj +1 more source
Reactome - a curated knowledgebase of biological pathways, 2004 Publisher Summary The covalent structure of the nucleobases in DNA and RNA directly provides the information for all genetic transactions. Living systems expend considerable energy in an ongoing struggle against spontaneous genetic change. The most wide-ranging threat to genetic integrity is posed by the attack of environmental agents on DNA ...
Gregory L. Verdine +1 more
openaire +5 more sources
Base excision repair and cancer [PDF]
Cancer Letters, 2012 Base excision repair is the system used from bacteria to man to remove the tens of thousands of endogenous DNA damages produced daily in each human cell. Base excision repair is required for normal mammalian development and defects have been associated with neurological disorders and cancer.
Drew L. Murphy +3 more
openaire +3 more sources
Extended Frontobasal Approach for Skull Base Lesions
Indian Journal of Neurosurgery, 2021 Background Lesions involving the skull base can be approached by a variety of surgical corridors and extended frontobasal approach is one of them. It provides quite a wide exposure to lesions in the midline of anterior skull base, paranasal sinuses, and ...
Mohd Faheem +2 more
doaj +1 more source
Base excision repair and its implications to cancer therapy
Essays in Biochemistry, 2020 Base excision repair (BER) has evolved to preserve the integrity of DNA following cellular oxidative stress and in response to exogenous insults. The pathway is a coordinated, sequential process involving 30 proteins or more in which single strand breaks
Gabrielle J. Grundy, J. Parsons
semanticscholar +1 more source
Molecules, 2020 Mitochondria emerged from bacterial ancestors during endosymbiosis and are crucial for cellular processes such as energy production and homeostasis, stress responses, cell survival, and more.
Karolina Boguszewska +3 more
semanticscholar +1 more source
Base Flipping in Nucleotide Excision Repair [PDF]
Journal of Biological Chemistry, 2006 UvrB, the ultimate damage-binding protein in bacterial nucleotide excision repair is capable of binding a vast array of structurally unrelated lesions. A beta-hairpin structure in the protein plays an important role in damage-specific binding. In this paper we have monitored DNA conformational alterations in the UvrB-DNA complex, using the fluorescent ...
Malta, E., Moolenaar, G.F., Goosen, N.
openaire +4 more sources
Bisphenol a promotes cell survival following oxidative DNA damage in mouse fibroblasts. [PDF]
PLoS ONE, 2015 Bisphenol A (BPA) is a biologically active industrial chemical used in production of consumer products. BPA has become a target of intense public scrutiny following concerns about its association with human diseases such as obesity, diabetes ...
Natalie R Gassman +6 more
doaj +1 more source
International Journal of Molecular Sciences, 2020 Oxidative stress with subsequent premutagenic oxidative DNA damage has been implicated in colorectal carcinogenesis. The repair of oxidative DNA damage is initiated by lesion-specific DNA glycosylases (hOGG1, NTH1, MUTYH). The direct evidence of the role
P. Vodicka +11 more
semanticscholar +1 more source