Results 21 to 30 of about 59,740 (306)
Base excision repair and cancer [PDF]
Cancer Letters, 2012 Base excision repair is the system used from bacteria to man to remove the tens of thousands of endogenous DNA damages produced daily in each human cell. Base excision repair is required for normal mammalian development and defects have been associated with neurological disorders and cancer.
Susan S, Wallace +2 more
openaire +2 more sources
High-throughput analysis of DNA repair in microplates towards identification of inhibitors
Genes and Environment, 2020 Environmental factors can inhibit DNA repair and cause indirect mutagenic actions. Here the author introduces a recent paper on a novel high-throughput system to analyze the various enzymatic activities involved in base excision repair. Such systems will
Hiroyuki Kamiya
doaj +1 more source
Base Flipping in Nucleotide Excision Repair [PDF]
Journal of Biological Chemistry, 2006 UvrB, the ultimate damage-binding protein in bacterial nucleotide excision repair is capable of binding a vast array of structurally unrelated lesions. A beta-hairpin structure in the protein plays an important role in damage-specific binding. In this paper we have monitored DNA conformational alterations in the UvrB-DNA complex, using the fluorescent ...
Malta, E., Moolenaar, G.F., Goosen, N.
openaire +3 more sources
Research Advances on Base Excision Repair Factor SmuG1 and Tumor
Zhongliu Fangzhi Yanjiu, 2019 Tumor is one of the diseases that seriously threaten human health. With the deepening of research, it is found that the role of DNA damage in the occurrence and development of tumors is more and more important.
ZHENG Lijiao +3 more
doaj +1 more source
Viruses with U-DNA: New Avenues for Biotechnology
Viruses, 2021 Deoxyuridine in DNA has recently been in the focus of research due to its intriguing roles in several physiological and pathophysiological situations. Although not an orthodox DNA base, uracil may appear in DNA via either cytosine deamination or thymine ...
Kinga K. Nagy +2 more
doaj +1 more source
Nature Communications, 2018 PARP1 has a well characterised role in DNA break repair and base excision repair, whereas the role of PARP2 is less well understood. Here, the authors show a requirement for PARP2 in stabilising replication forks that encounter base excision repair ...
George E. Ronson +7 more
doaj +1 more source
Base excision repair and the role of
Hereditary Cancer in Clinical Practice, 2007 The correction of exogenous and endogenous environmental insult to DNA involves a series of DNA repair mechanisms that reduce the likelihood of mutation accumulation and hence an increased probability of tumour development.
Kairupan Carla, Scott Rodney J
doaj +1 more source
Molecules, 2022 Endonuclease III (EndoIII) is a bifunctional DNA glycosylase with specificity for a broad range of oxidized DNA lesions. The genome of an extremely radiation- and desiccation-resistant bacterium, Deinococcus radiodurans, possesses three genes encoding ...
Filipe Rollo +5 more
doaj +1 more source
Base Sequence Context Effects on Nucleotide Excision Repair
Journal of Nucleic Acids, 2010 Nucleotide excision repair (NER) plays a critical role in maintaining the integrity of the genome when damaged by bulky DNA lesions, since inefficient repair can cause mutations and human diseases notably cancer. The structural properties of DNA lesions
Yuqin Cai +3 more
doaj +1 more source
Bisphenol a promotes cell survival following oxidative DNA damage in mouse fibroblasts.
PLoS ONE, 2015 Bisphenol A (BPA) is a biologically active industrial chemical used in production of consumer products. BPA has become a target of intense public scrutiny following concerns about its association with human diseases such as obesity, diabetes ...
Natalie R Gassman +6 more
doaj +1 more source