Results 51 to 60 of about 967,825 (378)
CHIPping Away at Base Excision Repair [PDF]
Molecular Cell, 2008 In this issue of Molecular Cell, Parsons et al. (2008) report that the E3 ubiquitin ligase CHIP regulates the stability of the base excision repair (BER) proteins XRCC1 and DNA Pol beta, adding a new level of regulation for BER.
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Exploiting Base Excision Repair to Improve Therapeutic Approaches for Pancreatic Cancer
Frontiers in Nutrition, 2015 Pancreatic ductal adenocarcinoma (PDA) is a highly chemoresistant and metastatic disease with a dismal 5-year survival rate of 6%. More effective therapeutic targets and approaches are urgently needed to tackle this devastating disease. The base excision
George eSharbeen +3 more
doaj +1 more source
Base excision repair of oxidative DNA damage: from mechanism to disease.
Frontiers in Bioscience, 2017 Reactive oxygen species continuously assault the structure of DNA resulting in oxidation and fragmentation of the nucleobases. Both oxidative DNA damage itself and its repair mediate the progression of many prevalent human maladies.
A. Whitaker +4 more
semanticscholar +1 more source
arXiv, 2022 Automated program repair is an emerging technology which consists of a suite of techniques to automatically fix bugs or vulnerabilities in programs. In this paper, we present a comprehensive survey of the state of the art in program repair. We first study the different suite of techniques used including search based repair, constraint based repair and ...
arxiv
Mammalian Base Excision Repair: Functional Partnership between PARP-1 and APE1 in AP-Site Repair. [PDF]
PLoS ONE, 2015 The apurinic/apyrimidinic- (AP-) site in genomic DNA arises through spontaneous base loss and base removal by DNA glycosylases and is considered an abundant DNA lesion in mammalian cells.
Rajendra Prasad +3 more
doaj +1 more source
DNA Base Excision Repair in Plants: An Unfolding Story With Familiar and Novel Characters
Frontiers in Plant Science, 2019 Base excision repair (BER) is a critical genome defense pathway that deals with a broad range of non-voluminous DNA lesions induced by endogenous or exogenous genotoxic agents.
T. Roldán-Arjona +2 more
semanticscholar +1 more source
Structural basis for APE1 processing DNA damage in the nucleosome
Nature Communications, 2022 AP endonuclease 1 (APE1) processes genomic AP sites during base excision repair. Here, the authors determine the structural mechanism used by APE1 to process nucleosomal AP sites, providing new insight into DNA repair in chromatin.
Tyler M. Weaver +5 more
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Lamin A/C promotes DNA base excision repair.
Nucleic Acids Research, 2019 The A-type lamins (lamin A/C), encoded by the LMNA gene, are important structural components of the nuclear lamina. LMNA mutations lead to degenerative disorders known as laminopathies, including the premature aging disease Hutchinson-Gilford progeria ...
S. Maynard +9 more
semanticscholar +1 more source
Base Excision Repair Variants in Cancer [PDF]
, 2017 Base excision repair (BER) is a key genome maintenance pathway that removes endogenously damaged DNA bases that arise in cells at very high levels on a daily basis. Failure to remove these damaged DNA bases leads to increased levels of mutagenesis and chromosomal instability, which have the potential to drive carcinogenesis.
Julie A. Dragon +4 more
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Initiating base excision repair in chromatin [PDF]
DNA Repair, 2018 The base excision repair (BER) pathway removes modified nucleobases that can be deleterious to an organism. BER is initiated by a glycosylase, which finds and removes these modified nucleobases. Most of the characterization of glycosylase activity has been conducted in the context of DNA oligomer substrates.
Sarah Delaney +2 more
openaire +3 more sources