Results 11 to 20 of about 40,087 (166)
Coarse-grained molecular dynamics simulations of base-pair mismatch recognition protein MutS sliding along DNA [PDF]
Biophysics and Physicobiology, 2022 DNA mismatches are frequently generated by various intrinsic and extrinsic factors including DNA replication errors, oxygen species, ultraviolet, and ionizing radiation.
Keisuke Inoue +2 more
doaj +2 more sources
Cryo-EM structure of translesion DNA synthesis polymerase ζ with a base pair mismatch [PDF]
Nature Communications, 2022 The structure of mismatched DNA-Polζ ternary complex provides a basis for understanding what makes Polζ adept at extending DNA synthesis past mismatched base pairs.
Radhika Malik +5 more
doaj +2 more sources
Base-Pair Mismatch Can Destabilize Small DNA Loops through Cooperative Kinking. [PDF]
Phys Rev Lett, 2019 Base pair mismatch can relieve mechanical stress in highly strained DNA molecules, but how it affects their kinetic stability is not known. Using single-molecule Fluorescence Resonance Energy Transfer (FRET), we measured the lifetimes of tightly bent DNA loops with and without base pair mismatch.
Jeong J, Kim HD.
europepmc +6 more sources
Structure of a DNA Glycosylase Bound to a Nicked T:G Mismatch-Containing DNA [PDF]
MoleculesMismatched T:G base pairs can arise during de novo replication as well as base excision repair (BER). In particular, the action of the gap-filling polymerase β (Polβ) can generate a T:G pair as well as a nick in the DNA backbone.
Hala Ouzon-Shubeita +3 more
doaj +2 more sources
Alleviation of C⋅C Mismatches in DNA by the Escherichia coli Fpg Protein
Frontiers in Microbiology, 2021 DNA polymerase III mis-insertion may, where not corrected by its 3′→ 5′ exonuclease or the mismatch repair (MMR) function, result in all possible non-cognate base pairs in DNA generating base substitutions.
Almaz Nigatu Tesfahun +10 more
doaj +1 more source
Importance of base-pair opening for mismatch recognition [PDF]
Nucleic Acids Research, 2020 AbstractMismatch repair is a highly conserved cellular pathway responsible for repairing mismatched dsDNA. Errors are detected by the MutS enzyme, which most likely senses altered mechanical property of damaged dsDNA rather than a specific molecular pattern.
Tomáš Bouchal +4 more
openaire +2 more sources
Frontiers in Chemistry, 2021 A detailed understanding of the mismatched base-pairing interactions in DNA will help reveal genetic diseases and provide a theoretical basis for the development of targeted drugs.
Yanhong Zhu +5 more
doaj +1 more source
Spontaneous and frequent conformational dynamics induced by A…A mismatch in d(CAA)·d(TAG) duplex
Scientific Reports, 2021 Base pair mismatches in DNA can erroneously be incorporated during replication, recombination, etc. Here, the influence of A…A mismatch in the context of 5′CAA·5′TAG sequence is explored using molecular dynamics (MD) simulation, umbrella sampling MD ...
Yogeeshwar Ajjugal +3 more
doaj +1 more source
SPR fingerprinting of mismatched base pair [PDF]
Nucleic Acids Symposium Series, 2004 Discrimination of mismatched base pairs having various flanking sequence from normal Watson-Crick base pairs were examined using SPR sensor surface where mismatch binding ligand (MBL) were immobilized. CC, CT, and TT mismatched base pair are distinguishable from wild type DNA by means of diaminonaphthyndine dimer (damND) immobilized sensor surface.
Akio, Kobori +3 more
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Preferential base pairing modes of T·T mismatches [PDF]
FEBS Letters, 2011 It has long been recognized that T·T mismatches can adopt two different modes of exchangeable wobble base pairs in which no preferential pairing mode has been observed. In this study, we have performed a systematic nuclear magnetic resonance (NMR) investigation to study the sequence context effect on the pairing modes of T·T mismatches.
He, Guoyun, Kwok, Chun Kit, Lam, Sik Lok
openaire +2 more sources