Results 31 to 40 of about 40,087 (166)
Scientific Reports, 2023 Proton transfer across hydrogen bonds in DNA can produce non-canonical nucleobase dimers and is a possible source of single-point mutations when these forms mismatch under replication.
Max Winokan +3 more
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Guanine- 5-carboxylcytosine base pairs mimic mismatches during DNA replication [PDF]
Scientific Reports, 2014 AbstractThe genetic information encoded in genomes must be faithfully replicated and transmitted to daughter cells. The recent discovery of consecutive DNA conversions by TET family proteins of 5-methylcytosine into 5-hydroxymethylcytosine, 5-formylcytosine and 5-carboxylcytosine (5caC) suggests these modified cytosines act as DNA lesions, which could ...
Shibutani, Toshihiro +13 more
openaire +2 more sources
PLoS ONE, 2017 The effect of S-substitution on the O6 guanine site of a 13-mer DNA duplex containing a G:T mismatch is studied using molecular dynamics. The structure, dynamic evolution and hydration of the S-substituted duplex are compared with those of a normal ...
Elaine Ann Moore, Yao-Zhong Xu
doaj +1 more source
Base-Pair Mismatch in DNA at 2.3A Resolution
Nucleosides and Nucleotides, 1985 Abstract X-ray single crystal analysis of the deoxyoctanucleotide d(GGGGCTCC)2 has revealed, for the first time, the existence of the G.T wobble mispair in an A-DNA double helical fragment.
Brown, T +3 more
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Imidazole-imidazole pair as a minor groove recognition motif for T:G mismatched base pairs [PDF]
Nucleic Acids Research, 1999 The T:G mismatched base pair is associated with many genetic mutations. Understanding its biological consequences may be aided by studying the structural perturbation of DNA caused by a T:G base pair and by specific probing of the mismatch using small molecular ligands.
X L, Yang +5 more
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Recognition of Mismatched Base Pairs in DNA [PDF]
Bulletin of the Chemical Society of Japan, 2009 Abstract Mismatch binding ligand (MBL) selectively binds to mismatched base pairs with discrimination of the nucleotide bases composing the mismatch. This review focuses on the inside story regarding the molecular design of MBL and its function, and potential application in genomic science.
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Characteristic mutations induced in the small intestine of Msh2-knockout gpt delta mice
Genes and Environment, 2021 Background Base pair mismatches in genomic DNA can result in mutagenesis, and consequently in tumorigenesis. To investigate how mismatch repair deficiency increases mutagenicity under oxidative stress, we examined the type and frequency of mutations ...
Yasunobu Aoki +6 more
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Biomédica: revista del Instituto Nacional de Salud, 2005 Introducción. El cáncer colorrectal es la segunda causa de morbilidad y mortalidad por cáncer en los países desarrollados. En Colombia es la quinta causa de muerte entre los diferentes cánceres.
Andrea Gómez +11 more
doaj +1 more source
Selective Preference of Parallel DNA Triplexes Is Due to the Disruption of Hoogsteen Hydrogen Bonds Caused by the Severe Nonisostericity between the G*GC and T*AT Triplets. [PDF]
PLoS ONE, 2016 Implications of DNA, RNA and RNA.DNA hybrid triplexes in diverse biological functions, diseases and therapeutic applications call for a thorough understanding of their structure-function relationships. Despite exhaustive studies mechanistic rationale for
Gunaseelan Goldsmith +2 more
doaj +1 more source
Detection of the C-C mismatched base pair by small ligands [PDF]
Nucleic Acids Symposium Series, 2003 We synthesized 2-aminonaphthyridine derivatives that specifically bind to cytosine-cytosine (C-C) mismatch. The binding of ligands was verified by observing an increase of melting temperature for 11-mer duplexes containing a mismatch in the presence of ligands.
Akio, Kobori +3 more
openaire +2 more sources