Results 41 to 50 of about 40,087 (166)

Free energy landscape of RNA binding dynamics in start codon recognition by eukaryotic ribosomal pre-initiation complex.

PLoS Computational Biology, 2021
Specific interaction between the start codon, 5'-AUG-3', and the anticodon, 5'-CAU-3', ensures accurate initiation of translation. Recent studies show that several near-cognate start codons (e.g.
Takeru Kameda, Katsura Asano, Yuichi Togashi   +2 more
doaj   +1 more source

Photoinduced excess electron injection into DNA duplexes containing mismatched base pairs [PDF]

Nucleic Acids Symposium Series, 2008
A series of DNA containing photoinduced electron donors and mismatched DNA base pairs have been prepared and applied for the chemical investigation of excess electron transfer (EET) in the duplex DNA. As the electron donors, phenothiazine (PTZ) with a flexible linker was tethered to the 5'-end or in the middle of the sequences, or diaminostilbene (DAS)
Takeo, Ito, Akiko, Kondo, Aiko, Hayashi, Tsukasa, Uchida, Kazuhito, Tanabe, Sei-ichi, Nishimoto   +5 more
openaire   +2 more sources

Single nucleotide polymorphism genotyping by two colour melting curve analysis using the MGB Eclipse™ Probe System in challenging sequence environment

Human Genomics, 2004
Probe and primer design for single nucleotide polymorphism (SNP) detection can be very challenging for A-T DNA-rich targets, requiring long sequences with lower specificity and stability, while G-C-rich DNA targets present limited design options to lower
Belousov Yevgeniy S, Welch Robert A, Sanders Silvia, Mills Alan, Kulchenko Alena, Dempcy Robert, Afonina Irina A, Walburger David K, Glaser Cynthia L, Yadavalli Sunita, Vermeulen Nicolaas MJ, Mahoney Walt   +11 more
doaj   +1 more source

Understanding Rad51 function is a prerequisite for progress in cancer research

QRB Discovery, 2020
The human protein Rad51 is double-edged in cancer contexts: on one hand, preventing tumourigenesis by eliminating potentially carcinogenic DNA damage and, on the other, promoting tumours by introducing new mutations.
Bengt Nordén, Masayuki Takahashi
doaj   +1 more source

Multiplexed smFRET Nucleic Acid Sensing Using DNA Nanotweezers

Biosensors, 2023
The multiplexed detection of disease biomarkers is part of an ongoing effort toward improving the quality of diagnostic testing, reducing the cost of analysis, and accelerating the treatment processes.
Anisa Kaur, Roaa Mahmoud, Anoja Megalathan, Sydney Pettit, Soma Dhakal   +4 more
doaj   +1 more source

Repair of defined single base-pair mismatches in Escherichia coli [PDF]

Proceedings of the National Academy of Sciences, 1985
Heteroduplexes with single base-pair mismatches of known sequence were prepared by annealing separated strands of bacteriophage λ DNA and used to transfect Escherichia coli . Each of the eight possible single base-pair mismatches was constructed.
C, Dohet, R, Wagner, M, Radman
openaire   +2 more sources

Molecular Dynamics Simulation of Melting of the DNA Duplex with Silver-Mediated Cytosine–Cytosine Base Pair

Computation
Metal-mediated base pairs in DNA double helix molecules open up broad opportunities for biosensors based on DNA clusters with silver due to their low toxicity and applicability in drug design.
Elena B. Gusarova, Natalya A. Kovaleva
doaj   +1 more source

Screening of anomalies in a double-stranded DNA via global electrical measurements

AIP Advances
We conduct two-terminal charge transport calculations to detect biological defects in three types of DNA sequences: periodic, quasi-periodic and random.
Sourav Kundu
doaj   +1 more source

Dependence of nucleosome mechanical stability on DNA mismatches

eLife
The organization of nucleosomes into chromatin and their accessibility are shaped by local DNA mechanics. Conversely, nucleosome positions shape genetic variations, which may originate from mismatches during replication and chemical modification of DNA ...
Thuy TM Ngo, Bailey Liu, Feng Wang, Aakash Basu, Carl Wu, Taekjip Ha   +5 more
doaj   +1 more source

Mismatch repair in recombination of bacteriophage T4

Biomolecular Concepts, 2012
The review focuses on the mechanism of mismatch repair in bacteriophage T4. It was first observed in T4 as an extra recombination mechanism, which contributed to the general recombination only when particular rII mutations were used as genetic markers ...
Shcherbakov Victor P.
doaj   +1 more source