Results 31 to 40 of about 353,589 (332)
Hfq CLASH uncovers sRNA-target interaction networks linked to nutrient availability adaptation
eLife, 2020 By shaping gene expression profiles, small RNAs (sRNAs) enable bacteria to efficiently adapt to changes in their environment. To better understand how Escherichia coli acclimatizes to nutrient availability, we performed UV cross-linking, ligation and ...
Ira Alexandra Iosub +8 more
doaj +1 more source
Manipulating a single adsorbed DNA for a critical endpoint [PDF]
, 2008 We show the existence of a critical endpoint in the phase diagram of unzipping of an adsorbed double-stranded (ds) polymer like DNA. The competition of base pairing, adsorption and stretching by an external force leads to the critical end point.
Bhattacharjee S. M. +9 more
core +2 more sources
Pre-mRNA splicing is a determinant of nucleosome organization. [PDF]
PLoS ONE, 2013 Chromatin organization affects alternative splicing and previous studies have shown that exons have increased nucleosome occupancy compared with their flanking introns. To determine whether alternative splicing affects chromatin organization we developed
Hadas Keren-Shaul +2 more
doaj +1 more source
Molecules, 2023 5-Amino-1-β-D-ribofuranosylimidazole-4-carboxamide 5′-monophosphate (ZMP) is a central intermediate in de novo purine nucleotide biosynthesis. Its nucleobase moiety, 5-aminoimidazole-4-carboxamide (Z-base), is considered an ambiguous base that can pair ...
Yuhei Nogi +3 more
doaj +1 more source
The base-pairing ability of the base pair-mimic nucleosides [PDF]
Nucleic Acids Symposium Series, 2007 The deoxyadenosine derivative tethering the phenyl group at N6 of deoxyadenosine (A(phe)) was previously found to have a property to stack strongly with adjacent nucleotide bases in a DNA duplex. On the other hand, it was also demonstrated that DNA polymerases selectively incorporated dTTP opposite A(phe) in a template DNA strand.
Shu-Ichi, Nakano +3 more
openaire +2 more sources
Ribosomal 18S rRNA base pairs with mRNA during eukaryotic translation initiation
Nature Communications, 2016 Prokaryotic translation initiation involves mRNA-ribosomal RNA base pairing interactions. Here, the authors provide evidence for a similar base pairing interactions occurring between the human h4 mRNA and helix 16 of the small subunit rRNA to position ...
Franck Martin +8 more
doaj +1 more source
Ground state and glass transition of the RNA secondary structure
, 2006 RNA molecules form a sequence-specific self-pairing pattern at low temperatures. We analyze this problem using a random pairing energy model as well as a random sequence model that includes a base stacking energy in favor of helix propagation.
Bundschuh +31 more
core +1 more source
Unconventional miR-122 binding stabilizes the HCV genome by forming a trimolecular RNA structure. [PDF]
, 2013 MicroRNAs (miRNAs) typically downregulate protein expression from target mRNAs through limited base-pairing interactions between the 5' 'seed' region of the miRNA and the mRNA 3' untranslated region (3'UTR). In contrast to this established mode of action,
Doudna, Jennifer A, Mortimer, Stefanie A
core +1 more source
Partition function and base pairing probabilities of RNA heterodimers
Algorithms for Molecular Biology, 2006 Background RNA has been recognized as a key player in cellular regulation in recent years. In many cases, non-coding RNAs exert their function by binding to other nucleic acids, as in the case of microRNAs and snoRNAs.
Stadler Peter F +5 more
doaj +1 more source
Life, 2020 It is possible that early life relied on RNA polymers that served as ribozyme-like catalysts and for storing genetic information. The source of such polymers is uncertain, but previous investigations reported that wet–dry cycles simulating prebiotic hot ...
Tue Hassenkam +3 more
doaj +1 more source