Results 61 to 70 of about 2,279,736 (377)

Divergent regulation of basement membrane trafficking by human macrophages and cancer cells

Nature Communications, 2022
Cancer cells and macrophages can infiltrate and remodel the extracellular matrix (ECM). Here, by using native basement membrane-interstitial matrix explants as model and live cell confocal imaging, the authors reveal divergent mechanisms used by cancer ...
Julian C. Bahr, Xiao-Yan Li, Tamar Y. Feinberg, Long Jiang, Stephen J. Weiss   +4 more
doaj   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Basement membrane proteins

Kidney International, 1992
Basement membranes are heterogeneous, highly specialized, electron-dense structures constructed from components of extracellular matrix proteins 20 to 200nm in width. They provide anchorage for adjacent cells as well as stimuli for cell differentiation, cell migration, and cell phenotype.
openaire   +2 more sources

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Tri-Layered Full-Thickness Artificial Skin Incorporating Adipose-Derived Stromal Vascular Fraction Cells, Keratinocytes, and a Basement Membrane

Bioengineering
Tissue-engineered artificial skin has the potential to enhance wound healing without necessitating extensive surgical procedures or causing donor-site morbidity.
Jung Huh, Seong-Ho Jeong, Eun-Sang Dhong, Seung-Kyu Han, Kyung-Chul Moon   +4 more
doaj   +1 more source

Electrospun Nanometer to Micrometer Scale Biomimetic Synthetic Membrane Scaffolds in Drug Delivery and Tissue Engineering: A Review

Applied Sciences, 2019
The scaffold technology research utilizes biomimicry to produce efficient scaffolds that mimic the natural cell growth environment including the basement membrane for tissue engineering.
Shaleena K. Pazhanimala, Driton Vllasaliu, Bahijja T. Raimi-Abraham   +2 more
doaj   +1 more source

Ultrastructural alteration of mouse lung by prolonged exposure to mixtures of helium and oxygen [PDF]

, 1975
Observed changes consist mainly of blebbing of capillary endothelium and alveolar epithelium, which is quite possibly indicative of cellular edema; also, there can be observed highly-convoluted basement membrane, alveolar debris, and increased numbers of
Harrison, G. A., Solomon, J. D.
core   +1 more source

Molecular characterisation of human penile carcinoma and generation of paired epithelial primary cell lines

Molecular Oncology, EarlyView.
Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad, Mahmood Hachim, Tom Bertin, Karolina Penderecka, Rifat Hamoudi, Saif Khan, Rui Henrique, Natalie Bergmoser, Manit Arya, Kalle Sipila, Matteo Vietri Rudan, Asif Muneer, Aamir Ahmed   +12 more
wiley   +1 more source

Increasingly transformed MCF-10A cells have a progressively tumor-like phenotype in three-dimensional basement membrane culture

Cancer Cell International, 2009
Background MCF-10A cells are near diploid and normal human mammary epithelial cells. In three-dimensional reconstituted basement membrane culture, they undergo a well-defined program of proliferation, differentiation, and growth arrest, forming acinar ...
Imbalzano Anthony N, Tatarkova Iva, Imbalzano Karen M, Nickerson Jeffrey A   +3 more
doaj   +1 more source

Association between matrix metalloproteinases-2 and -9 gene polymorphism with basement membrane disruption in oral lichen planus: A case-control pilot study

Journal of Oral Biology and Craniofacial Research, 2022
Objectives: This study investigated genetic polymorphism of matrix metalloproteinases (MMP) −2 and −9 in oral lichen planus (OLP) and their association with the basement membrane status.
Anubhuti Sood, Latha Mary Cherian, R. Heera, Sanish Sathyan, Moinak Banerjee   +4 more
doaj   +1 more source