Results 111 to 120 of about 56,684 (297)
Interferon-α antagonizes IL-3-mediated immunoregulatory functions of human basophils
, 2013 Human basophils are major inflammatory cells in maintaining chronic allergic asthma. It has been published that interferon-α (IFN-α) improves clinical symptoms of asthma patients. In contrast, IL-3 exacerbates airway inflammation by inducing IL-4, IL-8
Fux, Michaela +4 more
core
Evaluation of systemic consequences of brachycephalic obstructive airway syndrome in dogs
Veterinary Record, EarlyView.Abstract Background Brachycephalic obstructive airway syndrome (BOAS) results from upper airway anatomical abnormalities and may cause systemic effects depending on severity. Methods A prospective, case‒control and observational study was conducted.
Andréia Coutinho Facin +11 more
wiley +1 more source
Basophils are inept at promoting human Th17 responses [PDF]
, 2014 International audienceBasophils are the rare granulocytes and play an important role in the polarization of Th2 responses and protection against helminth parasites. In addition, basophils contribute to the pathogenesis of several diseases such as asthma,
Stephen-Victor, Emmanuel +5 more
core +1 more source
Immune Clues to Sinus Blues: Linking Biomarkers to Radiologic Score of Rhinosinusitis
World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.ABSTRACT Background Chronic rhinosinusitis (CRS) is a prolonged inflammatory condition of the nasal and paranasal sinuses that significantly affects quality of life. This study examines the relationship between CRS severity (based on Lund‐Mackay [LM] scores), osteitis, and systemic inflammatory markers, including neutrophil‐to‐lymphocyte ratio (NLR ...
Lubna Khreesha +10 more
wiley +1 more source
Basophils Support the Survival of Plasma Cells in Mice
, 2010 We have previously shown that basophils support humoral memory immune responses by increasing B cell proliferation and Ig production as well as inducing a Th2 and B helper phenotype in T cells.
Manuel Rodriguez Gomez +11 more
core +1 more source
Novel Bispecific Engagers Targeting the CεmX Domain of mIgE‐Expressing Cells
Allergy, EarlyView.We developed bispecific TCE & NKCE targeting the CεmX domain of mIgE to eliminate IgE‐producing cells. Both constructs demonstrated potent, specific, dose‐dependent cytotoxicity and selective immune activation in vitro. These results highlight their promise as off‐the‐shelf, potentially curative therapeutics for IgE‐associated allergic diseases ...
Constantin Möller +16 more
wiley +1 more source
Allergy, EarlyView.Exhaled decane and nonadecane discriminate allergic (AR + LAR) from non‐allergic (NAR + HC) subjects among individuals with chronic rhinitis. LAR patients display higher levels of exhaled nonadecane than NAR individuals at baseline. Subjects with FeNO≥ 25 ppb have higher levels of exhaled decane, nonanal, and styrene than individuals with FeNO < 25 ppb
Rosa Alba Sola‐Martinez +9 more
wiley +1 more source
Basophils: Are they only shadow dancers in allergy or more…? [PDF]
, 2007 Gibbs, Bernhard F
core +1 more source
IL-3 induces a Pim1-dependent antiapoptotic pathway in primary human basophils
, 2008 The contribution of basophils in allergic disease and other Th2-type immune responses depends on their persistence at sites of inflammation, but the ligands and molecular pathways supporting basophil survival are largely unknown.
Dahinden, Clemens A +12 more
core +1 more source