Results 101 to 110 of about 141,528 (311)

“Membrane‐Guided” Repair Strategy: Precision Delivery of GGT1 Degrader for Targeted Repair and Regeneration of Spinal Cord Neurons

Advanced Science, EarlyView.
This study confirms that GGT1 is a key driver of neuronal ferroptosis following spinal cord injury. We developed NSCm@EA, a biomimetic delivery system coated with neural stem cell membranes, for precise delivery of enocyanin to injured neurons. By combining targeted delivery with ubiquitination degradation mechanisms, this system promotes MGRN1 ...
Tao Yang, Lei Ye, Peigen Xie, Tao Song, Jian Chen, Heng Zhao, Zhengshan Liu, Xi Chen, Jianing Ding, Xintian Ding, Ao Shao, Miaomiao Wu, Fengdong Zhao, Siyue Tao, Tao You   +14 more
wiley   +1 more source

Microglial NLRP3-gasdermin D activation impairs blood-brain barrier integrity through interleukin-1β-independent neutrophil chemotaxis upon peripheral inflammation in mice

Nature Communications
Blood-brain barrier (BBB) disintegration is a key contributor to neuroinflammation; however, the biological processes governing BBB permeability under physiological conditions remain unclear.
Sung-Hyun Yoon, Chae youn Kim, Eunju Lee, Changjun Lee, Kyung-Seo Lee, Jaeho Lee, Hana Park, Bokeum Choi, Inhwa Hwang, Junhan Kim, Tae-Gyun Kim, Junghyun Son, Young-Min Hyun, Seunghee Hong, Je-Wook Yu   +14 more
doaj   +1 more source

Proposed model for OPC-BBB interaction.

, 2014
Trophic coupling between OPCs and cerebral endothelium may play an important role in the BBB function. TGF-β1 may mediate the cell-cell interaction; i.e.
Fumihiko Suwa (607049), Ji Hae Seo (554736), Eng H. Lo (112154), Anna C. Liang (607047), Mitsuyo Maeda (607046), Tomohiro Matsuyama (607050), Kazuhide Hayakawa (318525), Kyu-Won Kim (43973), Ken Arai (280828), Takakuni Maki (356905), Nobukazu Miyamoto (421321), Masafumi Ihara (302200), Loc-Duyen D. Pham (607048), Akihiko Taguchi (363459)   +13 more
core   +1 more source

Local monotonicity of Hausdorff measures restricted to curves in $\Bbb R^n$ [PDF]

, 2009
summary:We give a sufficient condition for a curve $\gamma: \Bbb R \to \Bbb R^n$ to ensure that the $1$-dimensional Hausdorff measure restricted to $\gamma$ is locally ...
Černý, Robert
core   +1 more source

In Vivo Electrochemical Monitoring of Safinamide Pharmacokinetics in the Brain Explores Its Correlation With Vision‐Related Neuronal Activity

Advanced Science, EarlyView.
An electrochemical platform based on differential pulse amperometry enables real‐time, selective tracking of safinamide pharmacokinetics in the living brain with high spatiotemporal resolution. When integrated with electrophysiology, this approach reveals that drug‐induced suppression of vision‐related neuronal activity provides mechanistic insight ...
Xiaoke Nan, Chuqi Li, Qianhe Dai, Junlan Zhou, Lijiao Cao, Yuying Liu, Jinger Chen, Meiping Xiong, Yuhang Jiang, Xianchan Li   +9 more
wiley   +1 more source

Transport of iron across the BBB.

, 2018
Transport of iron across the BBB.
James R. Connor (332038), Brian Chiou (5368118), Aaron B. Bowman (182842), Ian A. Simpson (5368124), Ethan S. Lippmann (1915207), Emma H. Neal (5368121)   +5 more
core   +1 more source

Diffusion‐Based Generative Model With Scaffold‐Hopping Strategy Yields Highly Potent Bioactive Molecules

Advanced Science, EarlyView.
SMarT‐Diff introduces a multi‐objective generative paradigm that integrates scaffold hopping with structure‐aware scoring to enable controlled exploration beyond the training distribution. The framework consistently balances drug‐likeness, synthesizes accessibility and bioactivity, yielding chemically diverse candidates with enhanced properties.
Yuwei Yang, Xiaoqing Gong, Shukai Gu, Jing Li, Bo Liu, Yanan Tian, Qianqian Zhang, Xiaojun Yao, Huanxiang Liu   +8 more
wiley   +1 more source

Blood-Nanoparticle Interactions Create a Brain Delivery Superhighway for Doxorubicin

International Journal of Nanomedicine
Zhuoxuan Li,1 Tatyana Kovshova,2 Julia Malinovskaya,2 Julian Knoll,1 Saeed Shanehsazzadeh,1 Nadezhda Osipova,2 Anastasia Chernysheva,3 Pavel Melnikov,2 Svetlana Gelperina,2 Matthias G Wacker1 1National University of Singapore, Department of Pharmacy and ...
Li Z, Kovshova T, Malinovskaya J, Knoll J, Shanehsazzadeh S, Osipova N, Chernysheva A, Melnikov P, Gelperina S, Wacker MG   +9 more
doaj  

Deformations of $\Bbb Q$-Calabi-Yau 3-Folds and $\Bbb Q$-Fano 3-Folds of Fano Index 1

, 1999
In this article, we prove that any $\Bbb Q$-Calabi-Yau 3-fold with only ordinary terminal singularities and any $\Bbb Q$-Fano 3-fold of Fano index 1 with only terminal singularities have $\Bbb Q ...
Minagawa Tatsuhiro
core  

Quantum Photothermal Self‐Monitoring Fiber Probes for In Vivo Photothermal Therapy

Advanced Science, EarlyView.
A miniaturized quantum photothermal fiber probe based on a metal/polymer/glass composite optoelectronic fiber that simultaneously guides lightwave and microwave was developed for the first time. The probe achieves enhanced photothermal conversion (13°C/mW, 25°C–120°C range) while providing real‐time self‐monitoring with 0.2°C thermal resolution at the ...
Wanjun Li, Ruixiao Hu, Jie Mao, Jin Wo, Yunsong Zhang, Liang Chen, Ying Liu, Zhibo Li, Yongxin Lin, Minghui Du, Yaofei Chen, Libing Zhou, Tuan Guo   +12 more
wiley   +1 more source