Results 11 to 20 of about 272,441 (303)
BBB-conquering antibodies [PDF]
Science-Business eXchange, 2014 Roche has developed an improved transferrin receptor–targeting strategy that dramatically increases delivery of biologics to the brain. The team showed proof of concept in mice and now needs to adapt the system for primate brains.
Benjamin Boettner
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Surgery on $\widetilde{\Bbb{SL}}\times\Bbb{E}^n$-manifolds
, 2004 7 pages, AMS-LaTeX file, To appear in the Canadian Mathematical Bulletin.
Hillman, J. A., Roushon, S. K.
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Translational applicability of human blood-brain barrier spheroid models for the development of brain-penetrant therapeutic antibodies [PDF]
Fluids and Barriers of the CNSDrug delivery systems play a key role in the development of new therapeutic strategies for brain diseases. Antibodies capable of crossing the blood–brain barrier (BBB) have attracted considerable attention as promising drug carriers.
Seiya Ohki +8 more
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Liver X Receptor as a Possible Drug Target for Blood-Brain Barrier Integrity [PDF]
Advanced Pharmaceutical Bulletin, 2022 Purpose: blood-brain barrier (BBB) is made of specialized cells that are responsible for theselective passage of substances directed to the brain. The integrated BBB is essential for precisecontrolling of the different substances passage as well as ...
Mahsa Eskandari, Ali Awsat Mellati
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Effect of Endurance Exercise and Methamphetamine Administration on the Expression of Blood-Brain Barrier Related Factors and BDNF in Hippocampus of Male Sprague-Dawley Rat [PDF]
운동과학, 2022 PURPOSE This study aimed to investigate the effect of short-term endurance exercise and methamphetamine administration on bloodbrain barrier (BBB)-related marker and brain-derived neurotrophic factor (BDNF) in the hippocampus of male Sprague-Dawley (SD ...
Su-Ryun Jung
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Developmental Cell, 2018 In this issue of Developmental Cell, Anbalagan et al. demonstrate that pituicytes, a subtype of astroglia, drive endothelial cell permeability in the zebrafish embryo neurohypophysis. This occurs via secretion of Vegfa/Tgfβ3 permeability factors that promote formation of fenestrae and the repression of anti-inflammatory retinoic acid signaling that ...
Thomas, Jean-Léon, Eichmann, Anne
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On bornological semi-abelian algebras [PDF]
Categories and General Algebraic Structures with Applications, 2021 If $\Bbb T$ is a semi-abelian algebraic theory, we prove that the category ${\rm Born}^{\Bbb T}$ of bornological $\Bbb T$-algebras is homological with semi-direct products.
Francis Borceux, Maria Manuel Clementino
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Triolein emulsion enhances temozolomide brain delivery: an experimental study in rats
Drug Delivery, 2021 Purpose To evaluate the enhancement of temozolomide (TMZ) delivery in the rat brain using a triolein emulsion. Materials and Methods Rats were divided into the five groups as following: group 1 (negative control), group 2 (treated with triolein emulsion ...
Won-Bae Seung +10 more
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Applied Sciences, 2019 Managing blood cholesterol levels is important for the treatment and prevention of diabetes, cardiovascular disease, and obesity. An easy-to-use, portable cholesterol blood test could accelerate more frequent testing by patients and at-risk populations ...
Kyongsik Yun +3 more
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