Results 221 to 230 of about 159,800 (296)

Inherited metabolic epilepsies–established diseases, new approaches

Epilepsia Open, EarlyView.
Abstract Inherited metabolic epilepsies (IMEs) represent the inherited metabolic disorders (IMDs) in which epilepsy is a prevailing component, often determining other neurodevelopmental outcomes associated with the disorder. The different metabolic pathways affected by individual IMEs are the basis of their rarity and heterogeneity.
Itay Tokatly Latzer, Phillip L. Pearl
wiley   +1 more source

Early micro- and nanoscale microglial responses to blood-brain barrier modulation by transcranial focused ultrasound. [PDF]

Theranostics
de Andrade EG, VanderZwaag J, Kofoed RH, Picard K, Pekarik KH, Carrier M, Ibáñez FG, Khakpour M, Hynynen K, Aubert I, Tremblay MÈ.   +10 more
europepmc   +1 more source

Intestinal microbiome alterations in pediatric epilepsy: Implications for seizures and therapeutic approaches

Epilepsia Open, EarlyView.
Abstract The intestinal microbiome plays a pivotal role in maintaining host health through its involvement in gastrointestinal, immune, and central nervous system (CNS) functions. Recent evidence underscores the bidirectional communication between the microbiota, the gut, and the brain and the impact of this axis on neurological diseases, including ...
Teresa Ravizza, Greta Volpedo, Antonella Riva, Pasquale Striano, Annamaria Vezzani   +4 more
wiley   +1 more source

Beyond Blood-Brain Barrier Crossing in Reperfusion-Era Ischemic Stroke: Interface-Matched Active-Entity Delivery and Translational Product Design. [PDF]

Int J Nanomedicine
Bu F, Cao Y, Chen F, Wen Y, Xiong L.
europepmc   +1 more source

The gut microbiome and drug‐resistant epilepsy: Microbiome–antiseizure medication interactions and implications for pharmacoresistance

Epilepsia Open, EarlyView.
Abstract Drug‐resistant epilepsy (DRE) affects approximately one‐third of patients with epilepsy and represents a major unmet clinical need. While traditional hypotheses of pharmacoresistance have focused on alterations in drug targets, efflux transporter overexpression, and intrinsic disease severity, the gut microbiome has recently emerged as a ...
Khaled Zammar, Majd A. AbuAlrob, Musab Ali, Simona Lattanzi, Boulenouar Mesraoua   +4 more
wiley   +1 more source

Advanced Drug Delivery in Pediatric Neurology: Developmental Barriers, Nanocarrier Strategies, and Translational Challenges. [PDF]

Int J Mol Sci
Teleanu RI, Bratu AG, Niculescu AG, Perjoc RȘ, Roza E, Teleanu DM, Vladâcenco OA, Cojocaru A, Grumezescu AM, Pintilie IM.   +9 more
europepmc   +1 more source

Preliminary evidence of long‐term safety and effectiveness of anti‐CGRP drugs for migraine prevention in people with comorbid epilepsy: A 52‐week follow‐up retrospective study

Epilepsia Open, EarlyView.
Abstract Migraine and epilepsy frequently coexist, but evidence on the safety of calcitonin gene‐related peptide (CGRP)‐targeting therapies in people with epilepsy is lacking. We evaluated long‐term migraine and epilepsy outcomes in a real‐world multicenter retrospective cohort of adults with comorbid migraine and epilepsy treated with anti‐CGRP ...
Marina Romozzi, Andrea Burgalassi, Francesco Ceriello, Pietro Martino, Giuliano Sette, Francesca Pistoia, Fabio Placidi, Diego Centonze, Luca Pani, Jacopo Canonichesi, Catello Vollono, Paolo Calabresi, Maria Albanese, Luigi Francesco Iannone   +13 more
wiley   +1 more source

Identification and whole-genome sequencing of blood-brain barrier-penetrating Riemerella anatipestifer isolated from chickens and ducks. [PDF]

Poult Sci
Li X, Cheng Y, Dang S, Wang J, Yang K, Guo H, Zhang R, Jiang S, Meng Y.   +8 more
europepmc   +1 more source

Autonomous Nanomedicine: Closing the Biological Validation Gap

Exploration, EarlyView.
Delivery of nanoparticles to tumors has not improved in over fifteen years, and biological testing remains slow and separate from formulation design. This review proposes adding a Biology step to the design cycle, using organ chips and patient‐derived organoids, and assesses the readiness of each required technology.
Yan Jun Lin, Izabella Komperda
wiley   +1 more source