Results 51 to 60 of about 141,528 (311)

Intrinsic Photoactive Star ZnPc–Poly(glutamate) Nanoplatforms for Multimodal Glioblastoma Therapy and Brain‐Targeted Delivery

Advanced Functional Materials, EarlyView.
An intrinsic photoactive star‐shaped zinc phtalocyanine‐poly(L‐glutamic acid) (ZnPc‐PGA) nanoplatform for multimodal glioblastoma (GBM) therapy and brain‐targeted elivery. A ZnPc‐PGA‐based multifunctional theranostic nanocarrier platform enables image‐guided, multimodal GBM therapy. ZnPc‐PGA nanocarriers support the integration of fluorescence imaging,
Amina Benaicha‐Fernández, Teodora Ranđelović, Ana Armiñán, Víctor Sebastián, Manuel Fuentes, Cristián Huck‐Iriart, Esther Masiá, Paula Carrascosa‐Marco, Pablo Juanes‐Velasco, Snežana Đorđević, Clara Bayona, Ignacio Ochoa, Maria Medel, Inmaculada Conejos‐Sánchez, María J. Vicent   +14 more
wiley   +1 more source

“Build back better” approach to disaster recovery: Research trends since 2006

Progress in Disaster Science, 2019
The “build back better” (BBB) approach to disaster recovery was first introduced in 2006 by the United Nations Secretary-General's Special Envoy for Tsunami Recovery, former US President William Clinton.
Glenn Fernandez, Iftekhar Ahmed
doaj   +1 more source

A Molecular Shielding Strategy to Develop Low Protein Binding, Renal Clearable Pan‐Cancer Near‐Infrared Probes

Advanced Functional Materials, EarlyView.
A molecular shielding strategy to convert “protein‐sticky” and “non‐tumor specific” clinical ICG dye, into a “low protein binding” and “tumor‐targeting” dye with prolonged blood circulation and renal clearance is described. These shielded ICGs demonstrate strong tumor accumulation and optimal tissue clearance, resulting in high tumor‐to‐background ...
Li Xiang, Kailin Mooney, Mingchong Dai, Morgan R. Stewart, Samantha Holland, Michael I. Henderson, Samuel Drennan, Ramon F. Barajas Jr., Jared M. Fischer, Adem Yildirim   +9 more
wiley   +1 more source

What “Hides” Behind Sovereign Debt Ratings? [PDF]

In this paper we study the determinants of sovereign debt credit ratings using rating notations from the three main international rating agencies, for the period 1995-2005. We employ panel estimation and random effects ordered probit approaches to assess
António Afonso, Pedro Gomes, Philipp Rother   +2 more
core   +2 more sources

The prevalence and factors associated for anti-tuberculosis treatment non-adherence among pulmonary tuberculosis patients in public health care facilities in South Ethiopia: a cross-sectional study

BMC Public Health, 2017
Background Evidence exists pointing out how non-adherence to treatment remains a major hurdle to efficient tuberculosis control in developing countries.
Tadele Teshome Woimo, Wondwossen Kassahun Yimer, Temesgen Bati, Hailay Abrha Gesesew   +3 more
doaj   +1 more source

BBB opening in V3.

, 2013
A 3D Spoiled Gradient-Echo (SPGR) T1-weighted sequence was applied after intravenous (IV) injection of gadodiamide 1 h after sonication. Gadodiamide presence in the brain parenchyma is induced by BBB opening.
Yao-Sheng Tung (347676), Tobias Teichert (76469), Vincent P. Ferrera (347678), Fabrice Marquet (347674), Elisa E. Konofagou (347680)   +4 more
core   +1 more source

BBB pathophysiology–independent delivery of siRNA in traumatic brain injury

, 2021
Copyright © 2021 The Authors, some rights reserved. Small interfering RNA (siRNA)–based therapeutics can mitigate the long-term sequelae of traumatic brain injury (TBI) but suffer from poor permeability across the blood-brain barrier (BBB).
Zhang, Jingdong, Lan, Haoyue, Joseph, John, Joshi, Nitin, Li, Wen, Conley, Grace, Langer, Robert, Li, Xiang-Ling, Karp, Jeffrey M, Aday, Sezin, Xu, Jun, Qiu, Jianhua, Mannix, Rebekah   +12 more
core   +1 more source

Translational Considerations for Injectable Biomaterials and Bioscaffolds to Repair and Regenerate Brain Tissue

Advanced Healthcare Materials, EarlyView.
The repair and regeneration of brain tissue faces both biological and technical challenges. Injectable bioscaffolds offer new opportunities to stimulate tissue regrowth in the brain by recruiting neural stem cells. Here, the translational issues are reviewed that need to be address to advance this promising new therapeutic approach from the bench to ...
Michel Modo, Alena Kisel
wiley   +1 more source

OBJECTIVE METHODS FOR DETERMINE THE SEVERITY AND PROGNOSIS OF PERINATAL HYPOXIC-ISCHEMIC CNS

Акушерство, гинекология и репродукция, 2016
Perinatal hypoxic-ischemic damage of the CNS is a major cause of mortality and neonatal incapacitating. The severity and prognosis is not always possible to accurately determine by clinical and tools methods of examination.
D. V. Blinov
doaj  

Brain Pericytes — Crucial Regulators of Neuroinflammation in Ischemic Stroke

Neuropharmacology and Therapy
Inflammation is a key element in the pathophysiology of ischemic stroke. The current effective treatments for ischemic stroke are almost exclusively based on reperfusion of occluded vessels.
Ziyi Chen, Qingsheng Li, Kaixin Wang, Lingfei Yang, Yanjie Jia, Zhe Gong   +5 more
doaj   +1 more source