Partial suppression of BCAA catabolism as a potential therapy for BCKDK deficiency
Molecular Genetics and Metabolism Reports, 2023 Branched chain ketoacid dehydrogenase kinase (BCKDK) deficiency is a recently described inherited neurometabolic disorder of branched chain amino acid (BCAA) metabolism implying increased BCAA catabolism.
Rebecca C Ahrens-Nicklas, Zoltan Arany
exaly +7 more sources
Translational Oncology, 2023 Background: Non-small cell lung cancer (NSCLC) is a leading cause of cancer death. Branched-chain amino acid (BCAA) homeostasis is important for normal physiological metabolism.
Duo Zuo, Jiawei Xiao
exaly +4 more sources
Human brown fat metabolism associates with systemic branched-chain amino acids homeostasis [PDF]
Molecular MetabolismCirculating branched-chain amino acids (BCAAs) are linked with insulin resistance, but the human tissues contributing to systemic BCAA homeostasis remain incompletely defined.
Mueez U-Din +20 more
doaj +2 more sources
Evaluation of therapeutic strategies targeting BCAA catabolism using a systems pharmacology model
Frontiers in Pharmacology, 2022 Background: Abnormal branched-chained amino acids (BCAA) accumulation in cardiomyocytes is associated with cardiac remodeling in heart failure. Administration of branched-chain α-keto acid dehydrogenase (BCKD) kinase inhibitor BT2 has been shown to ...
Alexey Goltsov, Kirill Peskov
exaly +3 more sources
Branched-chain amino acid metabolism and macrophage polarization: potential regulatory nodes and therapeutic targets in diabetes-associated metabolic inflammation [PDF]
Frontiers in Cellular and Infection MicrobiologyT2DM is characterized by chronic low-grade metabolic inflammation, and imbalanced macrophage polarization is a key immunological mechanism contributing to insulin resistance (IR), pancreatic β-cell damage, and diabetes progression.
Ruisi Yang +5 more
doaj +2 more sources
Defective branched-chain amino acid catabolism promotes pulmonary fibrosis by inducing apoptosis resistance of myofibroblasts in mice [PDF]
Cell Communication and SignalingBackground Pulmonary fibrosis (PF) is a life-threatening disease characterized by progressive dyspnea and worsening pulmonary function. Branched-chain amino acids (BCAAs) are a group of essential amino acids consisting of valine, leucine, and isoleucine.
Da-Yan Xiong +9 more
doaj +2 more sources
The effects of BCAA and creatine supplementation on anaerobic capacity and ball kicking speed in male football players [PDF]
Journal of Men's Health, 2021 Background and objective: The use of nutritional supplements has increased in recent years. This study analyzes the effects of Branched-Chain Amino Acids (BCAA) and creatine (CR) supplementation on anaerobic capacity and ball kicking speed in football
Ahmet Mor +3 more
doaj +1 more source
Nutritional support in a comprehensive program of prevention and treatment of sarcopenia
Российский журнал гериатрической медицины, 2023 Adequate nutrition with a high protein content is one of the main conditions in the complex treatment of sarcopenia. This review article considers strategies for maintaining the dietary derived protein and amino acids value in patients with sarcopenia ...
D. P. Kurmaev +6 more
doaj +1 more source
Acta Biomedica Scientifica, 2023 Due to the high prevalence of sarcopenia among elderly and old patients, early prevention and treatment of sarcopenia and its complications are relevant. Protein supplements can be used to maintain muscle strength and mass during aging.
D. P. Kurmayev +6 more
doaj +1 more source
Reduction of Muscle Injuries and Improved Post-exercise Recovery by Branched-Chain Amino Acid Supplementation: A Systematic Review and Meta-Analysis [PDF]
Journal of Fasting and Health, 2020 This meta-analysis and systematic review aimed to attain specific data on the effect of branched-chain amino acids (BCAAs) administration on muscle injuries and the indices of delayed-onset muscle soreness (DOMS) after exercise.
Mehran Rahimlou +4 more
doaj +1 more source